Apoptosis News and Research

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Apoptosis is programmed cell death, the body's normal method of disposing of damaged, unwanted, or unneeded cells.

The potential of targeting mitochondria-associated programmed cell death for age-related disease treatment

The review summarized the involvement of mitochondria in age-related disease progression and highlighted its potential as a therapeutic target of these diseases.

28 Aug 2023

Adolescence stress exposure impacts rodent brain development and behavior

Adolescence stress exposure in rodents can lead to reduced hippocampal cell proliferation, neuroplasticity, and cognitive impairments, as well as increased depressive-like behaviors. These effects may persist into adulthood but with variable impact.

27 Aug 2023

The role played by the gut microbiome in metabolizing selected sweeteners

The current evidence on the role of the gut microbiome in metabolizing sweeteners and their metabolites.

24 Aug 2023

The relationship between breast milk feeding and infants’ neurodevelopment via epigenetics

Researchers collated studies on the epigenetic advantages of breast milk feeding and neurodevelopment in infants.

22 Aug 2023

Regulation of cytotoxic T-cell differentiation and exhaustion by mTOR signaling

Researchers describe molecular signalling regulated by mTOR among memory and exhausted cytotoxic CD8+ T lymphocytes.

18 Aug 2023

Unveiling hidden threats: clustering loops in CAR-T cells impact cancer therapy

How complementarity-determining region (CDR) loops in the single-chain variable fragment (scFv) influence chimeric antigen receptor (CAR)-T cell behavior.

14 Aug 2023

How conversion between different types of cell death contributes to disease

Researchers elucidate the role of cell death in the pathogenesis of different diseases.

10 Aug 2023

CDK9 inhibitors: A promising new treatment for hematological malignancies

A new research perspective was published in Oncotarget's Volume 14 on August 7, 2023, entitled, "CDK9 INHIBITORS: a promising combination partner in the treatment of hematological malignancies."

9 Aug 2023

New PCNA inhibitor AOH1996 shows selective cancer cell killings and tumor suppression potential

Study described a small molecule inhibitor of proliferating cell nuclear antigen (PCNA) that selectively kills cancer cells.

4 Aug 2023

Recent advances in the understanding of the role and mechanism of CCAR2 in cancer

Researchers described the dual role of cell cycle and apoptosis regulator 2 (CCAR2) in cancer progression as a tumor suppressor and promoter.

4 Aug 2023

Reversing β-cell failure: A promising approach for type 2 diabetes treatment

Researchers examined current evidence on the reasons and implications of pancreatic beta-cell failure.

3 Aug 2023

Can vitamin D have positive effects on reducing cortical pathology, oxidative stress, and neurofilament light chain serum levels?

Researchers use an established murine model of cortical inflammatory demyelination to investigate the effects of vitamin D.

2 Aug 2023

The impact of medicinal plants on the gut microbiome in cancer

Researchers evaluate the associations between medicinal plants, the gut microbiome, and cancer.

2 Aug 2023

Phase 1 clinical trial underway to test City of Hope-developed cancer treatment

Researchers at City of Hope, one of the largest cancer research and treatment organizations in the United States, today published a new study explaining how they took a protein once thought to be too challenging for targeted therapy, proliferating cell nuclear antigen (PCNA), and developed a targeted chemotherapy that appears to annihilate all solid tumors in preclinical research.

1 Aug 2023

The effects of oxidative stress on women’s fertility

Scientists review existing literature to assess the relationship between oxidative stress and female infertility.

1 Aug 2023

How effective is physical activity in alleviating obesity-related inflammation in diabetes?

Scientists determine whether physical activity can be used as an effective intervention to mitigate obesity-related inflammation in diabetes.

1 Aug 2023

Newly identified protein plays a key role in the action of emerging anticancer therapies

Scientists have identified a protein that plays a pivotal role in the action of several emerging cancer therapies. The researchers say the discovery will likely aid efforts to fine-tune the use of immunotherapies against several challenging cancers.

31 Jul 2023

Study unravels how mitochondria call for help when under stress

Originally, the powerhouses of higher cells, the mitochondria, were independent organisms. Researchers at Goethe University Frankfurt have investigated to what extent their metabolism has blended with that of their host cells in the course of evolution, using the example of a mitochondrial stress response.

28 Jul 2023

The role of vasomotor reactivity in COVID-19 patients

Researchers searched and collated the most relevant published literature on cerebral hemodynamic changes in COVID-19 patients.

27 Jul 2023

The effect of diabetes medications on the risk of developing cancer

In an attempt to discern the risk of cancer posed by certain diabetic drugs as well, the authors of a recent paper performed a systematic review and meta-analysis of all studies over the past ten years dealing with this topic.

25 Jul 2023