Phosphorylation News and Research

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Novel computational analysis of prostate cancer suggests potential targets for therapy

Cancer researchers have applied a comprehensive set of analytical tools to lethal cases of metastatic prostate cancer, yielding a detailed map of the complex networks of interactions among genes and proteins that enable prostate cancer cells to proliferate and evade treatment.

11 Aug 2016

Novel therapeutic strategy could target multiple aspects of Alzheimer's disease

Therapeutic strategies targeting Alzheimer's disease (AD)-related molecule β-amyloid (Aβ), Tau protein and BACE enzyme have been recently explored. However the therapeutic efficacy for a single target is not ideal.

8 Aug 2016

Identifying new pathway of EZH2 gene may lead to targeted therapies for aggressive breast cancer

Scientists from A*STAR's Genome Institute of Singapore and the Cancer Science Institute of Singapore at the National University of Singapore came together to understand how EZH2, a cancer-promoting gene which is known to be involved in many types of cancers, is activated in breast cancer and lymphomas.

19 Jul 2016

Modifications to RUNX3 protein may promote cancer progression

Scientists from the Cancer Science Institute of Singapore at the National University of Singapore have discovered that modifications to a protein called RUNX3 may promote cancer progression.

18 Jul 2016

Scientists identify timing of major metabolic shift in developing neurons

Our brains can survive only for a few minutes without oxygen. Salk Institute researchers have now identified the timing of a dramatic metabolic shift in developing neurons, which makes them become dependent on oxygen as a source of energy.

13 Jul 2016

Researchers reveal molecular mechanism of autophagy initiation

Researchers revealed that Atg13 links autophagy initiation factors to each other using a string-like conformation, thereby promoting the association of diverse elements of the autophagy initiation machinery, initiating autophagosome formation through the recruitment of Atg9 vesicles and phosphorylation of various Atg factors.

12 Jul 2016

Why does appetite loss occur during illness? An interview with Prof. Conti and Prof. Francesconi

Appetite, as a word, come from the Latin appetitus, meaning "desire for.” Therefore, appetite can be defined as a pleasurable sensation or the desire to eat. This sensation is coordinated by several brain areas associated with reward processing such amygdala, hippocampus, ventral pallidum, nucleus accumbens and striatum, and others.

28 Jun 2016

Researchers identify new myosin kinase that could optimize heart contractions

The heart is the only muscle that contracts and relaxes continuously over a lifetime to pump oxygen-rich blood to the body's organs. Researchers at UT Southwestern Medical Center now have identified a previously unrecognized enzyme that could optimize contraction and lead to new strategies to treat heart failure.

21 Jun 2016

Breast cancer cells use new signaling pathway to cope with lack of oxygen levels inside tumors

Researchers have identified a new signaling pathway that helps cancer cells cope with the lack of oxygen found inside tumors. These are the results of a study published in Nature Cell Biology on June 20, and led by researchers at NYU Langone Medical Center and its Laura and Isaac Perlmutter Cancer Center, Princess Margaret Cancer Center, the University of Toronto, Harvard Medical School and Oxford University.

21 Jun 2016

S1P1R variation may cause differential patient responses to fingolimod treatment

Multiple sclerosis (MS) is an autoimmune disorder that results in demyelination of neurons. The FDA-approved drug fingolimod (Gilenya, FTY-720) modulates signaling by the bioactive lipid sphingosine-1-phosphate (S1P), which is linked to MS pathogenesis.

16 Jun 2016

PI3K/AKT/mTOR pathway plays key role in prostate tumor growth and progression

The research article - Targeting the PI3K/AKT/mTOR Pathway in Prostate Cancer Development and Progression: Insight to Therapy, by Dr Claudio Festuccia and published in Clinical Cancer Drugs, volume 3, issue 1 - discusses experimental and clinical data on the pharmacological inhibition of the Akt/mTOR pathways.

13 Jun 2016

First large-scale proteogenomic study helps pinpoint genes that drive breast cancer

Building on data from The Cancer Genome Atlas project, a multi-institutional team of scientists has completed the first large-scale "proteogenomic" study of breast cancer, linking DNA mutations to protein signaling and helping pinpoint the genes that drive cancer.

26 May 2016

ULK1, ULK2 enzymes play key role in maintaining cellular homeostasis

Researchers at St. Jude Children's Research Hospital have uncovered how two enzymes, ULK1 and ULK2, which are best known for their role in the degradation and recycling of proteins, control the trafficking of specific proteins.

23 May 2016

Unlocking the dark proteome: an interview with Dr Kriwacki

The term dark proteome refers to proteins whose structural features and thus functions are not well understood. Many proteins within the dark proteome do not fold into stable three-dimensional structures. These proteins are called intrinsically disordered proteins (IDPs) and feature highly flexible, disordered confirmations.

16 May 2016

Newly identified molecular pathway could lead to new treatments for reflux, incontinence disorders

Researchers at UMass Medical School have identified a new molecular pathway critical for maintaining the smooth muscle tone that allows the passage of materials through the digestive system.

25 Apr 2016

New GHz-class NMR magnet and probe technologies introduced by Bruker at ENC 2016

At the 57th Experimental Nuclear Magnetic Resonance Conference (www.enc-conference.org), Bruker announced new GHz-class NMR magnet and probe technologies to enable expanding frontiers in structural biology, membrane protein and intrinsically disordered protein (IDP) research.

From Bruker BioSpin - NMR, EPR and Imaging 11 Apr 2016

Phosphorylation News and Research

Novel computational analysis of prostate cancer suggests potential targets for therapy

Novel therapeutic strategy could target multiple aspects of Alzheimer's disease

Identifying new pathway of EZH2 gene may lead to targeted therapies for aggressive breast cancer

Modifications to RUNX3 protein may promote cancer progression

Scientists identify timing of major metabolic shift in developing neurons

Researchers reveal molecular mechanism of autophagy initiation

Why does appetite loss occur during illness? An interview with Prof. Conti and Prof. Francesconi

Researchers identify new myosin kinase that could optimize heart contractions

Breast cancer cells use new signaling pathway to cope with lack of oxygen levels inside tumors

S1P1R variation may cause differential patient responses to fingolimod treatment

PI3K/AKT/mTOR pathway plays key role in prostate tumor growth and progression

First large-scale proteogenomic study helps pinpoint genes that drive breast cancer

ULK1, ULK2 enzymes play key role in maintaining cellular homeostasis

Unlocking the dark proteome: an interview with Dr Kriwacki

Newly identified molecular pathway could lead to new treatments for reflux, incontinence disorders

New GHz-class NMR magnet and probe technologies introduced by Bruker at ENC 2016

Study reveals new activation mechanism for protein kinases

Gleevec could be novel therapeutic agent for type 2 diabetes

Cell biologists identify new way for curing cancer and vessel diseases

EPFL scientists develop cutting-edge treatment for Alzheimer's disease

Discover how SciY empowers scientists

Why use light scattering to analyze proteins and viral vectors?

Changing the landscape of R&D to build clinical success from the ground up

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