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TSRI scientists discover reason for lack of successful HCV vaccine design

Researchers have been trying for decades to develop a vaccine against the globally endemic hepatitis C virus (HCV). Now scientists at The Scripps Research Institute have discovered one reason why success has so far been elusive.

24 Oct 2016

Researchers discover how toxic proteins linked to neurological diseases impair membrane-less organelles

Researchers at St. Jude Children's Research Hospital have discovered the way toxic proteins linked to the most common forms of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) incapacitate membrane-less organelles inside cells.

21 Oct 2016

UCLA scientists take promising step towards killing mosquitoes that carry Zika virus and dengue fever

Five UCLA researchers were part of an international team that has used X-rays to reveal the structure of a molecule that is toxic to disease-carrying mosquitoes.

18 Oct 2016

Diamond publishes milestone paper that reveals discovery of genetic triggers behind birth defects

Researchers at the UK's national synchrotron facility, Diamond Light Source, have just published the 5000th scientific paper using data from the facility. This milestone marks a significant step for the synchrotron that is used by over 8,000 scientists each year.

7 Oct 2016

Research uncovers new clues to combat dengue and Zika virus

Structural biology research conducted at the U.S. Department of Energy's SLAC National Accelerator Laboratory has uncovered how small insecticidal protein crystals that are naturally produced by bacteria might be tailored to combat dengue fever and the Zika virus.

28 Sep 2016

Increasing specific brain fats could be potential strategy for preventing epileptic seizures

Increasing the concentration of specific fats in the brain could suppress epileptic seizures. This is evident from ground-breaking research carried out by the research groups of Professor Patrik Verstreken and Professor Wim Versées.

26 Sep 2016

Solid-state NMR in structural biology: an interview with Professor Tatyana Polenova

My research lab studies several classes of systems. We are mostly interested in looking at large protein assemblies to understand their structure, dynamics and how their properties relate to their malfunction in disease.

From Bruker BioSpin Group 21 Sep 2016

TSRI, IAVI scientists reveal new reductionist vaccine strategy to fight against HIV

A series of new studies led by scientists at The Scripps Research Institute and the International AIDS Vaccine Initiative describe a potential vaccination strategy to jump-start the selection and evolution of broadly effective antibodies to prevent HIV infection.

13 Sep 2016

Research offers new insights into underlying mechanisms of deadly cystic fibrosis

A minor hiccup in the sequence of a human gene can have devastating impacts on health. Such flaws cause cystic fibrosis (CF), a disease affecting the lungs and other vital organs, often leading to death by the age of 30.

9 Sep 2016

Groundbreaking research unravels structure of infectious prions that cause mad cow disease

Groundbreaking research from the University of Alberta has identified the structure of the infectious prion protein, the cause of "mad cow disease" or BSE, chronic wasting disease in deer and elk and Creutzfeldt-Jakob disease in humans, which has long remained a mystery.

8 Sep 2016

Researchers identify new gene for type 2 diabetes at well-established genomic location

Gene researchers have used sophisticated scientific tools to reveal a new gene for type 2 diabetes at a well-established genomic location.

31 Aug 2016

Researchers describe structure of Alzheimer fibrils at atomic resolution

Elongated fibres (fibrils) of the beta-amyloid protein form the typical senile plaque present in the brains of patients with Alzheimer's disease.

5 Aug 2016

ZMYND8 protein can suppress metastasis-linked genes in prostate cancer

Although it reads like European license plate number, a protein known as ZMYND8 has demonstrated its ability to block metastasis-linked genes in prostate cancer, according to a study at The University of Texas MD Anderson Cancer Center.

28 Jul 2016

TSRI scientists develop new dual-targeting drug candidate for treating diabetes and bone disease

In addition to its more obvious ills, type 2 diabetes is a condition closely associated with bone fractures, increasing the risk of fractures twofold. To make matters worse, certain anti-diabetic drugs further increase this risk, particularly in postmenopausal women, severely limiting their treatment options.

28 Jul 2016

Scientists unveil structure of Zika NS1 protein

Researchers have revealed the molecular structure of a protein produced by the Zika virus that is thought to be involved in the virus's reproduction and its interaction with a host's immune system.

26 Jul 2016

Neutrons key to discovering new HIV drugs? An interview with Dr Matthew Blakeley

Neutron crystallography allows us to determine the three-dimensional structures of biological macromolecules, such as proteins, by means of the diffraction of neutrons from the regularly spaced atoms of a crystal.

21 Jul 2016

GSK and University of Leicester team up to develop novel drugs to treat blood cancer

A collaboration between the University of Leicester and global pharmaceutical company GlaxoSmithKline has been established to discover and develop novel medicines to treat aggressive forms of blood cancer.

21 Jul 2016

Curza receives SBIR grant to develop new class of broad spectrum antibiotics

Curza Global, LLC, a company based on technology developed at the University of Utah, has been awarded a Phase I Small Business Innovation Research grant of $598,770 entitled "Natural product-inspired antibacterials with unique ribosomal binding" that will provide two years of support.

7 Jul 2016

Researchers uncover sensing mechanism of food poisoning bacteria found in shellfish

UT Southwestern Medical Center researchers have uncovered a mechanism that a type of pathogenic bacteria found in shellfish use to sense when they are in the human gut, where they release toxins that cause food poisoning.

5 Jul 2016

TSRI scientists develop new strategy to design potential HIV vaccine candidates

Want to catch a criminal? Show a mugshot on the news. Want to stop HIV infections? Get the immune system to recognize and attack the virus's tell-tale structure. That's part of the basic approach behind efforts at The Scripps Research Institute to design an AIDS vaccine.

29 Jun 2016