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COVID-19 infection risk and outcomes explained by the cell receptor genetic variability

Genetic variants in the angiotensin‐converting enzyme 2 (ACE2) receptor, utilized by the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) for cell entry, are predicted to either encourage or inhibit interaction with viral proteins and subsequently contribute to genetic risk in coronavirus disease (COVID-19). This is the key finding of a new study available on the preprint server bioRxiv*.

5 May 2020

Novel coronavirus mutation could spell trouble for vaccine development

New research shows that the novel coronavirus is undergoing mutations that could make it challenging to develop a vaccine against. There are a few vaccine candidates that are in the making to prevent COVID-19. With a potential for mutation, the vaccines that are being developed now may not work against the emergent mutated strains worry Taiwanese and Australian researchers. The study is titled, “Analysis of the mutation dynamics of SARS-CoV-2 reveals the spread history and emergence of 2 RBD mutant with lower ACE2 binding affinity.”

19 Apr 2020

Preclinical study characterizes the binding affinity and selectivity of a selective FLT3 inhibitor

Oncotarget Volume 11, Issue 11 reported that in this preclinical study, we characterized the binding affinity and selectivity of quizartinib, a small-molecule inhibitor of FLT3, and AC886, the active metabolite of quizartinib, compared with those of other FLT3 inhibitors.

21 Mar 2020

Engineered botox more effective

A new study reports on an engineered botulinum neurotoxin (botox) that is more effective as well as safer to use in various medical procedures. The study was published in March 2020 in the open-access journal PLOS Biology.

17 Mar 2020

Researchers show new potential path to improve bone-repair procedures

Researchers are moving closer to a new approach for improving spinal fusion procedures and repairing broken or defective bones that avoids an over-production of bone that commonly occurs in current treatments.

3 Jan 2020

Epigenome editing could repair genetic brain disorder

A new study published in the journal Nature Communications shows that it may be possible to reverse gene mutations that cause brain disorders, using a very precisely targeted epigenome editing technique. This type of gene editing does not change the gene’s DNA sequence itself but is focused on correcting epigenome changes only. The condition that was corrected in the study is called the WAGR syndrome and is associated with obesity and intellectual disability in people.

11 Dec 2019

New compound may enhance dengue vaccine efficacy by simulating amino acid deficiency

A new study published in the journal Science Signaling on November 26, 2019, describes a mouse experiment, in which the immune response to the dengue vaccine was boosted when the mice were first given halofuginone, a plant compound that is well known to herbalists.

27 Nov 2019

Game-changing diagnostic test for prion diseases

Researchers have developed an effective way of testing for prion diseases, a group of fatal neurodegenerative illnesses caused by abnormally folded proteins.

8 Nov 2019

Osaka University Hospital begins clinical research for prostate cancer diagnosis using PET imaging

Osaka University Hospital began Japan's first clinical research for diagnosis of prostate cancer using PET (positron emission tomography) scan results in September 2019.

7 Oct 2019

Veravas launches advanced solutions to address biotin interference in diagnostic tests

Veravas, Inc., an emerging diagnostic company, launched a portfolio of products that can improve the accuracy of current diagnostic test results by helping laboratory professionals detect and manage biotin interference in patient samples with VeraTest Biotin and VeraPrep Biotin.

12 Jul 2019

Scientists reveal mechanism of tumor metastasis and tumor-suppressive role of UDP-glucose

Scientists from Dalian Institute of Chemical Physics and Shanghai Institute of Biochemistry and Cell Biology of the Chinese Academy of Sciences revealed that UDP-glucose accelerates SNAI1 mRNA decay and impairs lung cancer metastasis.

27 Jun 2019

Using Light Scattering to Characterize Protein-Nucleic Acid Interactions

Harnessing the interactions between DNA, RNA, and proteins holds much promise for detecting biomarkers, diagnosing disease, and improving cancer-targeting therapeutics. Quantifying these interactions is essential for understanding and controlling their biomolecular mechanisms.

From Waters | Wyatt Technology 26 Jun 2019

New probe can identify and latch onto proteins on surface of endoplasmic reticulum

Sigma receptors are proteins found on mainly the surface of endoplasmic reticulum in certain cells. Sigma-1 and sigma-2 are the two main classes of these receptors.

20 Jun 2019

Researchers develop technique to track proteins on the surfaces of endoplasmic reticulum in cells

Researchers from Kanazawa University on the development of a technique to closely track a specific protein on the surfaces of endoplasmic reticulum (ER) in cells. Their findings are published in Bioorganic and Medicinal Chemistry.

17 Jun 2019

Ensuring 100% Accuracy in Antibody Protein Sequencing

The purpose of antibody protein sequencing is to accurately deduce every single amino acid present in the primary sequence. This is an issue with isoleucine and leucine which have the same molecular weight. Rapid Novor has developed a technique to determine these with 100% accuracy.

From Rapid Novor Inc 16 Apr 2019

Study finds how Salmonella bacteria sense presence of bile acids in their surroundings

When bacteria enter the digestive tracts of their hosts, including humans, they encounter a highly acidic environment.

21 Mar 2019

Blood donors' leftover immune cells provide crucial insights into antibody affinity

During some kinds of blood donations, you get most of your blood back. For example, platelet donation involves a procedure in which donor blood is filtered to harvest the platelets for medical use and the rest of the blood components are returned to the donor's body.

11 Mar 2019