Genetic News and Research

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Genetic risk information enables tailored breast cancer screening

Recent results from researchers at the University of Helsinki indicate that genetic risk information can help tailor and target breast cancer screening more effectively to the women who would benefit the most.

4 Mar 2024

AI and predictive medicine: Recent advances

The potential of deep learning (DL) in enhancing predictive modeling for omics data analysis.

4 Mar 2024

Researchers discover how "leaky" mitochondria can drive harmful inflammation

Researchers have discovered how "leaky" mitochondria – the powerhouses of our cells – can drive harmful inflammation responsible for diseases such as lupus and rheumatoid arthritis.

4 Mar 2024

New scSNV-seq technique unveils genetic drivers of diseases like cancer and Alzheimer's

Scientists have developed a new screening tool to uncover how genetic changes affect gene activity and can lead to diseases such as cancer, autoimmunity, neurodegeneration and cardiovascular disease. This new tool enables the investigation of thousands of DNA mutations identified by genetic studies in one experiment, guiding the development of advanced diagnostics and treatments.

4 Mar 2024

Prioritizing biologically motivated approaches in Mendelian randomization studies

Mendelian randomization, a powerful tool in medical research, helps us understand whether certain factors truly cause disease.

1 Mar 2024

Novel genetic mechanisms of tetracycline resistance in gut bacteria discovered

Antibiotic resistance is a significant and growing medical problem worldwide. Researchers at the Marine Biological Laboratory (MBL) and collaborators have found a novel genetic arrangement that may help a common bacterium in the human gut, Bacteroides fragilis, protect itself from tetracycline, a widely used antibiotic.

1 Mar 2024

MRI monitoring reduces breast cancer mortality in women with BRCA1 mutations

An international study, published in the JAMA Oncology journal, in which the Clinical Oncology group of the Sant Pau Research Institute participated, has revealed that MRI monitoring in women with mutations in the BRCA1 genes significantly reduces breast cancer mortality without the need for preventive mastectomy.

1 Mar 2024

Unlocking the molecular mysteries of autism and intellectual disability

A new study from a team of McGill University and Vanderbilt University researchers is shedding light on our understanding of the molecular origins of some forms of autism and intellectual disability.

1 Mar 2024

Penn engineers develop targeted lung delivery system using lipid nanoparticles

Penn Engineers have developed a new means of targeting the lungs with lipid nanoparticles (LNPs), the miniscule capsules used by the Moderna and Pfizer-BioNTech COVID-19 vaccines to deliver mRNA, opening the door to novel treatments for pulmonary diseases like cystic fibrosis.

1 Mar 2024

The association between diet and colorectal cancer risk

The genetic variants that modify the association between diet and colorectal cancer (CRC) risk.

1 Mar 2024

Study reveals the body's molecular response to prolonged fasting

New findings reveal that the body undergoes significant, systematic changes across multiple organs during prolonged periods of fasting.

1 Mar 2024

Impaired spatial navigation signals early Alzheimer's risk

People at risk of Alzheimer's disease have impaired spatial navigation prior to problems with other cognitive functions, including memory, finds a new study led by UCL researchers.

29 Feb 2024

Gut bacteria diversity linked to body weight, athletes show healthier profiles

Systematic review reveals gut microbiome variations correlate with body composition changes across lifespan, highlighting differences between obese individuals and athletes.

29 Feb 2024

Breakthrough gene silencing method slashes cholesterol for a year in mice, no DNA damage

Researchers developed an engineered transcriptional repressor that durably silences the Pcsk9 gene in mice, reducing cholesterol levels for up to a year with a single treatment, showcasing a potential breakthrough in genetic disorder treatments without the risks of DNA mutation.

29 Feb 2024

Research uncovers key therapeutic target for reversing accelerated atherosclerosis in diabetes

Diabetes accelerates the development of atherosclerosis, increasing the incidence of cardiovascular events.

29 Feb 2024

SickKids study offers new path for pediatric rare disease clinical trials

Using a novel methodology, researchers at The Hospital for Sick Children (SickKids) are the first in pediatric research to use data from an international real-world cohort to overcome the barriers associated with conducting randomized clinical trials in children with rare diseases.

29 Feb 2024

Breakthrough CRISPR technique unlocks insights about cancer immunology

Over the past two decades, the immune system has attracted increasing attention for its role in fighting cancer.

29 Feb 2024

UCLA researchers uncover dual role of GAN gene in neurological disorder, head and neck cancer

Researchers from the UCLA Health Jonsson Comprehensive Cancer Center show for the first time that a gene usually linked to giant axonal neuropathy, a rare and severe neurological condition, also plays a role in inhibiting aggressive tumor cell growth in head and neck cancers.

29 Feb 2024

Is posttraumatic epilepsy associated with long-term dementia risk?

The associations between post-traumatic epilepsy (PTE) and the risk of dementia.

29 Feb 2024

New tool unravels the mystery of DNA-RNA interactions in single cells

Cancers begin with abnormal changes in individual cells, and the ability to track the accumulation of mutations at the single-cell level can shed new light on the early stages of the disease. Such knowledge could enable more effective early detection and treatment options for patients as well as more accurate predictions of disease progression.

29 Feb 2024