The association between diet and colorectal cancer risk

NewsGuard 100/100 Score

In a nested case-control study published in JAMA Network Open, researchers from South Korea investigated the genetic variants that modify the association between diet and colorectal cancer (CRC) risk.

They found that single-nucleotide polymorphisms (SNPs) in the EPDR1 gene can modify the impact of fish intake on the risk of CRC.

Further, they highlighted the potential pathways underlying the link between the consumption of tea, milk, cheese, and alcohol and the development of CRC.

Study: Genome-Wide Interaction Study of Dietary Intake and Colorectal Cancer Risk in the UK Biobank. Image Credit: BlurryMe/Shutterstock.comStudy: Genome-Wide Interaction Study of Dietary Intake and Colorectal Cancer Risk in the UK Biobank. Image Credit: BlurryMe/Shutterstock.com

Background

CRC is the second most prevalent cancer in Europe (12.9%) and stands among the top three most-diagnosed cancers in both men and women in the United Kingdom (UK). Evidence suggests that the consumption of meat and alcohol is associated with an increased risk of CRC.

On the other hand, the intake of fish, milk, fruits, and vegetables shows an inverse association with CRC-risk. Genetic factors, accounting for 3.5% to 10.5% of variations, may influence dietary habits and CRC-risk.

For example, specific genes impact the metabolism of carcinogens in cooked meat and modify associations. Similarly, cruciferous vegetables are found to be inversely linked to CRC in individuals with certain enzyme deficiencies.

Advances in technology have enabled genome-wide association studies that reveal genetic susceptibility loci and facilitate the assessment of gene-diet interactions across the genome.

Dietary factors may influence CRC pathogenesis by modulating gene expression through metabolites or activating complex metabolic pathways.

Previous studies explored the role of nutrition in various carcinogenesis pathways, including deoxyribonucleic acid (DNA) synthesis, epigenetic control via one-carbon metabolism, DNA damage, phase 1 and 2 enzymes, tumor promotion, and polynucleotide repair.

Although potential mechanisms suggesting the association between dietary intake and CRC have been proposed, the specific genes and pathways involved in this association have not been extensively documented.

Therefore, researchers in the present study conducted a gene-diet interaction analysis using genetic data and CRC cases to identify genetic variants that influence the association between diet and CRC-risk.

About the study

Data was obtained from the UK Biobank of participants enrolled between 2006 and 2010. Individuals with sex mismatches, putative sex chromosome aneuploidy, non-White racial background, and prevalent cancer at recruitment were excluded.

A total of 4,686 participants (mean age 60.7 years) and 14,058 matched controls (mean age 60.4 years) were included in the study. In both the cohorts, 57.8% of participants were male.

Dietary intake information, including milk, cheese, poultry, red meat, processed meat, fish, coffee, tea, alcohol, and total fruit and vegetables, was collected through a touchscreen food frequency questionnaire.

Although the median follow-up was 12.4 years, only 10.2% of participants had data from more than one follow-up visit. Imputed genotyping data underwent quality control, resulting in 4,122,345 variants for the genome-wide interaction (GWI) analysis.

CRC cases were identified based on the International Statistical Classification of Diseases and Related Health Problems (revision 10).

Gene-based and gene-enrichment analyses were conducted. Statistical analysis involved the Cochran-Mantel-Haenszel χ2 test, conditional logistic model, principal component analysis, and p-values for gene or gene-set levels interactions.

Results and discussion

As compared to controls, the cases had a higher proportion of smokers, higher frequency of alcohol consumption, and higher prevalence of obesity.

Individuals consuming red meat ≥3 times per week and processed meat ≥2 times per week showed a higher CRC-risk (odds ratio 1.16) after adjusting for confounding factors.

Additionally, those who consumed alcohol more than thrice a week showed an increased CRC-risk compared to those with alcohol intake less than once a week. Notably, a protective association against CRC was found for participants consuming ≥4 servings of fruit daily compared to those with ≤ 2 servings daily.

324 SNPs were suggested to interact with dietary intake without statistical significance. Genes EPDR1 and ZNRF2 were identified in the gene-based analysis, with EPDR1 showing significance with fish consumption through multiple SNPs.

Further, gene-set enrichment analysis revealed overrepresented pathways (OR, ART, KRT, PRM, and TNP) for genes interacting with cheese, milk, tea, and alcohol consumption, respectively.

The study's findings could contribute to personalized preventive strategies and interventions for CRC.

However, the study is limited by the analysis of CRC-risk based on dietary information from a single time point, limited availability of dietary data at multiple follow-up visits, potential instability in certain nutritional factors, inability to confirm specific SNPs modifying diet-CRC associations, and a lack of validation in non-European populations.

Conclusion

In conclusion, the study reveals several SNPs showing suggestive interactions with dietary intake, particularly significant interactions between EPDR1 and total fish consumption affecting CRC- risk.

The findings point to various biological and functional pathways potentially underlying the association and highlight the need for further investigation through experimental studies.

Journal reference:
Dr. Sushama R. Chaphalkar

Written by

Dr. Sushama R. Chaphalkar

Dr. Sushama R. Chaphalkar is a senior researcher and academician based in Pune, India. She holds a PhD in Microbiology and comes with vast experience in research and education in Biotechnology. In her illustrious career spanning three decades and a half, she held prominent leadership positions in academia and industry. As the Founder-Director of a renowned Biotechnology institute, she worked extensively on high-end research projects of industrial significance, fostering a stronger bond between industry and academia.  

Citations

Please use one of the following formats to cite this article in your essay, paper or report:

  • APA

    Chaphalkar, Sushama R.. (2024, March 01). The association between diet and colorectal cancer risk. News-Medical. Retrieved on April 14, 2024 from https://www.news-medical.net/news/20240301/The-association-between-diet-and-colorectal-cancer-risk.aspx.

  • MLA

    Chaphalkar, Sushama R.. "The association between diet and colorectal cancer risk". News-Medical. 14 April 2024. <https://www.news-medical.net/news/20240301/The-association-between-diet-and-colorectal-cancer-risk.aspx>.

  • Chicago

    Chaphalkar, Sushama R.. "The association between diet and colorectal cancer risk". News-Medical. https://www.news-medical.net/news/20240301/The-association-between-diet-and-colorectal-cancer-risk.aspx. (accessed April 14, 2024).

  • Harvard

    Chaphalkar, Sushama R.. 2024. The association between diet and colorectal cancer risk. News-Medical, viewed 14 April 2024, https://www.news-medical.net/news/20240301/The-association-between-diet-and-colorectal-cancer-risk.aspx.

Comments

The opinions expressed here are the views of the writer and do not necessarily reflect the views and opinions of News Medical.
Post a new comment
Post

While we only use edited and approved content for Azthena answers, it may on occasions provide incorrect responses. Please confirm any data provided with the related suppliers or authors. We do not provide medical advice, if you search for medical information you must always consult a medical professional before acting on any information provided.

Your questions, but not your email details will be shared with OpenAI and retained for 30 days in accordance with their privacy principles.

Please do not ask questions that use sensitive or confidential information.

Read the full Terms & Conditions.

You might also like...
Linking lifestyle to longevity: How diet and hypertension sway risks for heart disease and cancer