Clinical Trial News and Research

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Combination therapy reduces recovery time in COVID-19 patients, clinical trial finds

A clinical trial involving COVID-19 patients hospitalized at UT Health San Antonio and University Health, among roughly 100 sites globally, found that a combination of the drugs baricitinib and remdesivir reduced time to recovery, according to results published Dec. 11 in the New England Journal of Medicine.

16 Jan 2021

New drug reduces tumor volume and pain in patients with neurofibromatosis type 1

Based on preclinical studies of an investigational drug to treat peripheral nerve tumors, researchers at Children's Hospital of Philadelphia (CHOP) as part of the Neurofibromatosis Clinical Trials Consortium have shown that the drug, cabozantinib, reduces tumor volume and pain in patients with the genetic disorder neurofibromatosis type 1 (NF1).

15 Jan 2021

MVA SARS-CoV-2 vaccine candidate shows strong immunogenicity in preclinical trials

A new study reports the preclinical testing of a recombinant MVA (rMVA) candidate vaccine against SARS-CoV-2, the agent that is causing the current COVID-19 pandemic.

14 Jan 2021

Researchers receive $5.1 million to expand clinical trial of drug to prevent ARDS in COVID-19 patients

Researchers evaluating whether an investigational oral drug, vadadustat, can help prevent acute respiratory distress s to expand the Phase II clinical trial at The University of Texas Health Science Center at HoustonQ.

13 Jan 2021

Drug found to be safe and effective for treating patients with obesity and type 2 diabetes

A new study confirms that treatment with Bimagrumab, an antibody that blocks activin type II receptors and stimulates skeletal muscle growth, is safe and effective for treating excess adiposity and metabolic disturbances of adult patients with obesity and type 2 diabetes.

13 Jan 2021

Influenza drug enisamium a potential COVID-19 treatment

Researchers in Europe and the United States have demonstrated the potential of the influenza drug enisamium as a treatment for infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent that causes coronavirus disease 2019 (COVID-19).

13 Jan 2021

Study shows how cardiosphere-derived cells replenish damaged tissues in dilated cardiomyopathy

Dilated cardiomyopathy (DCM) is a condition caused by the weakening of the heart muscle, affecting the ventricles (chambers in the heart that push blood around the body as it contracts).

13 Jan 2021

Researchers discover a new approach to inhibit intrahepatic cholangiocarcinoma

Reprogramming the rich connective tissue microenvironment of a liver cancer known as intrahepatic cholangiocarcinoma (ICC) inhibits its progression and resistance to standard chemotherapy in animal models, researchers from Massachusetts General Hospital have found.

12 Jan 2021

Scientists determine ideal dose of stem cells to control HIV

Scientists have determined the optimal conditions following a stem cell transplant that could control HIV without the need of an everyday pill, according to a study published today in eLife.

12 Jan 2021

Robotic device powered by patients’ own brains helps improve stroke rehabilitation

Stroke survivors who had ceased to benefit from conventional rehabilitation gained clinically significant arm movement and control by using an external robotic device powered by the patients' own brains.

12 Jan 2021

Stimulation method helps some people with spinal cord injury to regain hand and arm mobility

Almost 18,000 Americans experience traumatic spinal cord injuries every year. Many of these people are unable to use their hands and arms and can't do everyday tasks such as eating, grooming or drinking water without help.

12 Jan 2021

Study shows COVID-19 pneumonia is different from typical pneumonia

Bacteria or viruses like influenza that cause pneumonia can spread across large regions of the lung over the course of hours. In the modern intensive care unit, these bacteria or viruses are usually controlled either by antibiotics or by the body's immune system within the first few days of the illness.

12 Jan 2021

MDC researchers develop a potent weapon against lymphomas

MDC researchers have developed a new approach to CAR T-cell therapy. The team has shown in Nature Communications that the procedure is very effective, especially when it comes to fighting follicular lymphomas and chronic lymphocytic leukemia, the most common type of blood cancer in adults.

11 Jan 2021

Could Ivermectin be an effective antiviral against SARS-CoV-2?

A double-blind, randomized, placebo-controlled clinical trial has recently demonstrated that Ivermectin, an anti-parasitic drug, can reduce in-hospital mortality rate of COVID-19 patients.

11 Jan 2021

Researchers reach important milestone in leishmaniasis vaccine development

Researchers have taken an important step forward in developing a controlled human infection model to test leishmaniasis vaccines.

11 Jan 2021

Proteogenomics can help determine effective treatment for head and neck squamous cell carcinoma

Proteogenomic analysis may offer new insight into matching cancer patients with an effective therapy for their particular cancer.

7 Jan 2021

Main bioactive compound of ginger root may protect against autoimmune disease progression

Naturopathic medicine, or herbal medicine, is all the rage, especially among young people. But how much of this is supported by science?

6 Jan 2021

Mount Sinai and Rumi Scientific join hands to initiate autism drug discovery pipeline

The Seaver Autism Center for Research and Treatment at the Icahn School of Medicine at Mount Sinai and Rumi Scientific announced today that they will team up to initiate a drug discovery pipeline for rare genetic disorders that carry a high risk of autism.

6 Jan 2021

NIAID set to conduct large monoclonal SARS-CoV-2 antibody clinical trial

A large clinical trial, known as the Accelerating COVID-19 Therapeutic Interventions and Vaccines (ACTIV-2), is set to take place, which aims to test monoclonal antibody efficacy and safety in people who have mild or moderate COVID-19.

6 Jan 2021

Cholesterol-lowering drugs may protect women's hearts from damage caused during chemotherapy

Statins, common cholesterol-lowering medications, may protect women's hearts from damage caused during chemotherapy for early-stage breast cancer, according to new research published today in the Journal of the American Heart Association, an open access journal of the American Heart Association.

6 Jan 2021

Clinical Trial News and Research

Combination therapy reduces recovery time in COVID-19 patients, clinical trial finds

New drug reduces tumor volume and pain in patients with neurofibromatosis type 1

MVA SARS-CoV-2 vaccine candidate shows strong immunogenicity in preclinical trials

Researchers receive $5.1 million to expand clinical trial of drug to prevent ARDS in COVID-19 patients

Drug found to be safe and effective for treating patients with obesity and type 2 diabetes

Influenza drug enisamium a potential COVID-19 treatment

Study shows how cardiosphere-derived cells replenish damaged tissues in dilated cardiomyopathy

Researchers discover a new approach to inhibit intrahepatic cholangiocarcinoma

Scientists determine ideal dose of stem cells to control HIV

Robotic device powered by patients’ own brains helps improve stroke rehabilitation

Stimulation method helps some people with spinal cord injury to regain hand and arm mobility

Study shows COVID-19 pneumonia is different from typical pneumonia

MDC researchers develop a potent weapon against lymphomas

Could Ivermectin be an effective antiviral against SARS-CoV-2?

Researchers reach important milestone in leishmaniasis vaccine development

Proteogenomics can help determine effective treatment for head and neck squamous cell carcinoma

Main bioactive compound of ginger root may protect against autoimmune disease progression

Mount Sinai and Rumi Scientific join hands to initiate autism drug discovery pipeline

NIAID set to conduct large monoclonal SARS-CoV-2 antibody clinical trial

Cholesterol-lowering drugs may protect women's hearts from damage caused during chemotherapy

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