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New analysis of cancer cells identifies 370 targets for smarter, personalized treatments

A new, systematic analysis of cancer cells identifies 370 candidate priority drug targets across 27 cancer types, including breast, lung and ovarian cancers.

13 Jan 2024

Increased cholesterol levels in adolescence linked to early heart damage

Heart disease is the number one killer disease in the world. Elevated cholesterol and dyslipidaemia in children and adolescents increase the risk of premature death in the mid-forties and subclinical atherosclerosis in the mid-twenties.

13 Jan 2024

Novel type 2 oral polio vaccine secures WHO prequalification for broader rollout

The novel type 2 oral polio vaccine (nOPV2), developed by a team including scientists from the Medicines and Healthcare products Regulatory Agency (MHRA), has today (9 January) been quality-assured (prequalified) by the World Health Organization (WHO).

13 Jan 2024

Community health workers champion genetic literacy for minorities

Changes to DNA, known as mutations, can increase the likelihood of developing cancer. Specifically, people with mutations in their BRCA 1 and 2 genes are substantially more likely to develop hereditary breast and ovarian cancers. But how do people know if they have these mutations?

12 Jan 2024

Defective gene triggers uncontrolled immune attack in young lupus patients

A group of researchers lead by Min Ae Lee-Kirsch from the Department of Pediatrics, Medical Faculty, TUD Dresden University of Technology (Germany), studied four patients from two families who developed symptoms of SLE in the first years of life.

12 Jan 2024

Drug-resistant Candida: Study uncovers evolutionary tricks of a fungal pathogen

Global fungal infections, which affect one billion people and cause 1.5 million deaths each year, are on the rise due to the increasing number of medical treatments that heighten vulnerability.

12 Jan 2024

Dark chocolate cuts hypertension risk: Sweet news from latest study

Study finds dark chocolate intake significantly lowers the risk of essential hypertension, suggesting a beneficial role in cardiovascular health.

12 Jan 2024

Genetics linked to BMI differences across socio-economic groups, study finds

Study in the International Journal of Obesity finds genetic factors contribute to socio-economic position (SEP) related differences in BMI, with lower SEP groups showing higher genetic predisposition to increased BMI.

11 Jan 2024

Groundbreaking study uncovers hundreds of genetic markers linked to insulin resistance

A genome-wide study of 402,398 individuals identifies 369 SNPs associated with insulin resistance, offering insights into metabolic diseases and potential therapeutic targets.

11 Jan 2024

Superbug spread is not just about antibiotics, new study shows

For the first time, researchers have analyzed the impact of antibiotic use on the rise of treatment-resistant bacteria over the last 20 years in the UK and Norway. They show that while the increase in drug use has amplified the spread of superbugs, it is not the only driver.

11 Jan 2024

First organoid model of the human conjunctiva produced

The Organoid group at the Hubrecht Institute produced the first organoid model of the human conjunctiva. These

11 Jan 2024

Study identifies distinct CD4+ T cell changes in various autoimmune diseases

Much like ripples on the water can betray powerful currents below the surface, small changes in our bodies can sometimes be an indicator of a serious condition.

11 Jan 2024

Scientists identify critical protein complex for targeted cancer treatment

The repair of damage to genetic material (DNA) in the human body is carried out by highly efficient mechanisms that have not yet been fully researched.

11 Jan 2024

Unraveling the skin microbiome's impact on aging

The effects of aging and external factors like UV exposure on skin are well documented. As people age or spend more time in the sun, their skin tends to become drier and more wrinkled,

11 Jan 2024

Non-smokers' lung cancer among top five global cancer-related deaths in 2023

The development of lung cancer in individuals who have never smoked.

11 Jan 2024

Alzheimer's disease found to have five distinct subtypes

Researchers identified five distinct molecular subtypes of Alzheimer's disease using proteomic sequencing, suggesting personalized treatment approaches based on each subtype's unique genetic and pathological characteristics.

10 Jan 2024

Study shows how cancer care can be transformed from 'one size fits all' approach into precision healthcare

In the largest study of its kind, scientists today report how combining health data with whole genome sequence (WGS) data in patients with cancer can help doctors provide more tailored care for their patients.

10 Jan 2024

Pangolins' genetic makeup linked to increased coronavirus susceptibility

Research reveals pangolins' vulnerability to coronavirus due to innate immune gene pseudogenization, impacting their antiviral response.

10 Jan 2024

mRNA therapy shows promise for curing children's rare liver disease

By exploiting the technology used in Covid-19 vaccines, a team led by UCL, King's College London and Moderna scientists has created an effective therapy for a rare disease, in a study in mice, demonstrating the technology's potential therapeutic use in people.

10 Jan 2024