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Genetic risk factor for West Nile virus infection identified

People who lack a cell surface protein called CCR5 are highly resistant to infection by HIV but may be at increased risk of developing West Nile virus (WNV) illness when exposed to the mosquito-borne virus, report researchers from the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH).

18 Jan 2006

Tomato juice keeps emphysema from developing in new animal model of degenerative disease

Feeding tomato juice to mice kept them from developing emphysema after cigarette smoke exposure that was long enough to induce emphysema in a control group, Japanese researchers report in February issue of the American Journal of Physiology-Lung Cellular and Molecular Physiology.

10 Jan 2006

Aussie team discover rare breast stem cell responsible for tissue growth

Australian scientists have discovered the rare stem cell that drives the formation of all breast tissue.

9 Jan 2006

alphaB-crystallin may be a useful molecular marker to identify women with aggressive breast cancer

A groundbreaking study led by Northwestern University researchers has demonstrated that a protein called alphaB-crystallin, which normally protects cells from stress damage, triggers events that may cause breast cancer when overactive.

6 Jan 2006

Australian researchers discover stem cell that drives the formation of all breast tissue

Victorian Breast Cancer Research Consortium scientists from The Walter and Eliza Hall Institute, using a mouse model, have discovered the rare stem cell that drives the formation of all breast tissue.

5 Jan 2006

Researchers move closer to understanding the basis of a severe epilepsy and mental retardation

Researchers at the University of California, San Diego (UCSD) School of Medicine took a step closer to understanding the basis of a severe epilepsy and mental retardation syndrome with work published in the January 5, 2006 issue of the journal Neuron.

5 Jan 2006

p11 gene may play a key role in depression

For the more than 18 million Americans who suffer from depressive illnesses, the best pharmacological treatments are those that increase levels of serotonin, the brain chemical that regulates mood, sleep and memory.

5 Jan 2006

Long term air pollution exposure leads to acceleration of atherosclerosis and vascular inflammation

Findings indicate a significant independent association between exposure to long term air pollution and the acceleration of atherosclerosis and vascular inflammation in an animal model.

21 Dec 2005

Anti-Abeta42 and Anti-Abeta40–specific monoclonal antibodies attenuate amyloid deposition in an Alzheimer disease mouse model

Current hypotheses suggest that it is the accumulation over time of amyloid beta peptide 1–42 (Abeta42) that triggers changes in the brain that lead to cognitive dysfunction in Alzheimer's disease.

13 Dec 2005

Inhibition of FLT3 signaling targets DCs to ameliorate autoimmune disease

Scientists at the Johns Hopkins Kimmel Cancer Center have found that a gene pathway linked to a deadly form of leukemia may provide a new way to treat autoimmune diseases, including multiple sclerosis.

2 Dec 2005

Valproic acid (Depakote) may help treat lupus

A common anti-seizure drug may be effective against certain conditions associated with lupus, according to animal research at Wake Forest University School of Medicine.

20 Nov 2005

Genetically modified allow scientists to examine the potential usefulness of new therapies for Alzheimer's disease

Researchers with the University of Florida and the California Institute of Technology have developed a new strain of genetically modified mice that allow scientists to examine the potential usefulness of new therapies for Alzheimer's disease.

20 Nov 2005

Lowering calorie intake may help Parkinson's disease

A new Oregon Health & Science University and Portland Veterans Affairs Medical Center study suggests that early-stage Parkinson's disease patients who lower their calorie intake may boost levels of an essential brain chemical lost from the neurodegenerative disorder.

20 Nov 2005

Trichostatin A may fight lupus and atherosclerosis simultaneously

People with lupus are prone to premature accelerated atherosclerosis. Now scientists at Wake Forest University School of Medicine think they have a way to prevent or decrease this atherosclerosis and prevent heart attacks.

16 Nov 2005

Statin drug reverses learning and attention deficits in a mouse model of the genetic disorder Neurofibromatosis type I

This week, researchers report evidence that a statin drug already shown to be safe for use in humans has proven effective at correcting cell-cell communication and curing learning disfunction in a mouse model of Neurofibromatosis type I, a human genetic disorder that causes learning disabilities in millions of people worldwide.

7 Nov 2005

Tryptophan metabolites play an important role in the immune system

Tryptophan is the source of Thanksgiving legend and grist for a "Seinfeld" episode, but it's not the chemical that you'd expect to find in Lawrence Steinman's lab.

7 Nov 2005

Ospemifine may also help to prevent breast cancer

A tamoxifen-like drug developed by UC Davis and Finnish researchers, now in clinical testing as a treatment for vaginal atrophy, may also help to prevent breast cancer, two preliminary studies suggest.

3 Nov 2005

Calcitriol - promising chemopreventive agent that may prevent prostate cancer

The active metabolite of vitamin D, calcitriol, and other vitamin D analogs are promising chemopreventive agents that may prevent prostate cancer, according to a study presented today at the American Association for Cancer Research's 4th annual Frontiers in Cancer Prevention Research meeting in Baltimore.

3 Nov 2005

Paclitaxel may help treat scleroderma

Using a novel model for scleroderma, researchers from Duke University Medical Center have discovered two important insights into this devastating disorder - the anti-cancer drug paclitaxel (Taxol) may prevent the skin thickening and small blood vessel destruction that characterizes the disease.

1 Nov 2005

Novel mouse model of medulloblastoma

A collaboration of researchers, led by Dr. Martine Roussel of St. Jude Children's Research Hospital, has developed a novel mouse model of medulloblastoma -- the most prevalent malignant pediatric brain tumor -- that the researchers hope will more accurately represent the genetic changes involved in human brain tumor development.

30 Oct 2005

Mouse Model News and Research

Genetic risk factor for West Nile virus infection identified

Tomato juice keeps emphysema from developing in new animal model of degenerative disease

Aussie team discover rare breast stem cell responsible for tissue growth

alphaB-crystallin may be a useful molecular marker to identify women with aggressive breast cancer

Australian researchers discover stem cell that drives the formation of all breast tissue

Researchers move closer to understanding the basis of a severe epilepsy and mental retardation

p11 gene may play a key role in depression

Long term air pollution exposure leads to acceleration of atherosclerosis and vascular inflammation

Anti-Abeta42 and Anti-Abeta40–specific monoclonal antibodies attenuate amyloid deposition in an Alzheimer disease mouse model

Inhibition of FLT3 signaling targets DCs to ameliorate autoimmune disease

Valproic acid (Depakote) may help treat lupus

Genetically modified allow scientists to examine the potential usefulness of new therapies for Alzheimer's disease

Lowering calorie intake may help Parkinson's disease

Trichostatin A may fight lupus and atherosclerosis simultaneously

Statin drug reverses learning and attention deficits in a mouse model of the genetic disorder Neurofibromatosis type I

Tryptophan metabolites play an important role in the immune system

Ospemifine may also help to prevent breast cancer

Calcitriol - promising chemopreventive agent that may prevent prostate cancer

Paclitaxel may help treat scleroderma

Novel mouse model of medulloblastoma

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

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