Receptor News and Research

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Discovery of new receptor that interacts with SARS-CoV-2 spike, suppresses infection

Researchers recently conducted a study to identify host factors affecting cellular interactions of the SARS-CoV-2 spike protein.

16 Nov 2021

SARS-CoV-2 replicates in human placenta with release of infectious viral particles

The current study analyzed the interaction of SARS-CoV-2 at the human maternal-fetal interface by using an advanced ex vivo model.

16 Nov 2021

Broad neutralization capability of potent nanobody against SARS-CoV-2 variants

A new study has described the molecular basis of the neutralization potency and breadth of nanobodies.

16 Nov 2021

Rapid finger stick test to detect antibodies against SARS-CoV-2 variants

A new preprint reports a semi-quantitative test that can measure neutralizing antibodies to the SARS-CoV-2 pathogen at the point of care, using a finger stick or venipuncture blood.

16 Nov 2021

Deficient spike-specific T cell responses and inability to neutralize SARS-CoV-2 variants 12 month post-infection

Researchers conducted a comprehensive, longitudinal, long-term immune study, including functional assays to assess immune fitness against antigenically different VoC. The study is currently available on the preprint server medRxiv* while awaiting peer review.

15 Nov 2021

Immune response elicited by SARS-CoV-2 vaccines in infliximab and vedolizumab-treated patients with IBD

A recent study evaluates the immune responses elicited by COVID-19 vaccines in infliximab- or vedolizumab-treated IBD patients.

15 Nov 2021

Histone mimicry as a mechanism through which SARS-CoV-2 disrupts host cell epigenetic regulation

A recent study investigates histone mimicry as a mechanism by SARS-CoV-2 for disrupting epigenetic regulation to evade host cell responses to infection.

15 Nov 2021

Study identifies a host factor that reflects different levels of inflammation within mild COVID-19 cases

A new study investigates serum from COVID-19 convalescents and uninfected individuals to determine the molecular mechanisms of host responses.

15 Nov 2021

Common hypertension drug not effective in slowing down the progression of Alzheimer's disease

New research led by the University of Bristol, has shown the drug losartan, normally used to treat high blood pressure (hypertension), is not effective in slowing down the progression of Alzheimer's disease (AD) in people with mild-to-moderate disease after 12 months of treatment.

15 Nov 2021

Could drugs derived from microalgae be effective against COVID-19?

Researchers discuss the ability of some microalgae metabolites to prevent cytokine storm syndrome during COVID-19.

15 Nov 2021

Potential biomarkers of coagulopathy and disease severity in COVID-19

Scientists have investigated the presence of specific biomarkers in hospitalized COVID-19 patients

15 Nov 2021

Vaccination protects against COVID-19 related hospitalization in patients with and without comorbidity

Researchers from University Medical Centre Utrecht have been investigating the efficiency of vaccines against the alpha variant in the Netherlands.

15 Nov 2021

Detection of a coronavirus similar to SARS-CoV-2 in Cambodian bats

Now, a new study published in the journal Nature Communications reports the identification of SARS-CoV-2 related coronaviruses in two horseshoe bats sampled in Cambodia in 2010.

15 Nov 2021

Partial resistance to neutralizing antibodies and enhanced transmissibility of SARS-CoV-2 Delta variant

A new study estimates the efficacy of the immune response induced by vaccination and natural COVID-19 infection against the Kappa and Delta lineages.

14 Nov 2021

Higher order protein catenation leads to the development of artificial antibodies

Chemical topology is a unique dimension for protein engineering. Over the past few years, the discovery of topological nontrivial proteins in nature has already revealed their many potential functional benefits, such as enhanced thermal/mechanical/chemical stability.

12 Nov 2021

GPR126 gene may play an essential role in placental development, study reveals

Scientists working with an experimental mouse model at the Centro Nacional de Investigaciones Cardiovasculares have identified the essential role of the gene GPR126 in the development of the placenta during pregnancy.

12 Nov 2021

COVID-19 vaccination humoral immune response in individuals with diabetes

A new study investigated the humoral immune response and side effects related to COVID-19 vaccines in individuals with type 1 diabetes and type 2 diabetes.

12 Nov 2021

Impact of mutations on binding affinity of SARS-CoV-2 variants with ACE2 and existing antibodies

Researchers explained their analysis of the mechanisms that trigger the docking of SARS-CoV-2 variants to ACE2 and the antibodies, referred to as protein-protein docking.

12 Nov 2021

Study may pave the way for a more personalized approach to COVID-19 diagnosis and treatment

Using some of the most advanced molecular sequencing tools available to evaluate COVID-19 rapid autopsy tissues, researchers have identified four major regulatory pathways, specific molecular effectors behind COVID-19 symptoms, and differences that drive diverging clinical courses among individual patients.

11 Nov 2021

Analysis of immunodeficient patients granted REGEN-COV under compassionate use COVID-19 program

A team of scientists describe the safety and response to REGEN-COV® for COVID-19 patients with immunodeficiency-associated antibody disorders.

11 Nov 2021

Receptor News and Research

Discovery of new receptor that interacts with SARS-CoV-2 spike, suppresses infection

SARS-CoV-2 replicates in human placenta with release of infectious viral particles

Broad neutralization capability of potent nanobody against SARS-CoV-2 variants

Rapid finger stick test to detect antibodies against SARS-CoV-2 variants

Deficient spike-specific T cell responses and inability to neutralize SARS-CoV-2 variants 12 month post-infection

Immune response elicited by SARS-CoV-2 vaccines in infliximab and vedolizumab-treated patients with IBD

Histone mimicry as a mechanism through which SARS-CoV-2 disrupts host cell epigenetic regulation

Study identifies a host factor that reflects different levels of inflammation within mild COVID-19 cases

Common hypertension drug not effective in slowing down the progression of Alzheimer's disease

Could drugs derived from microalgae be effective against COVID-19?

Potential biomarkers of coagulopathy and disease severity in COVID-19

Vaccination protects against COVID-19 related hospitalization in patients with and without comorbidity

Detection of a coronavirus similar to SARS-CoV-2 in Cambodian bats

Partial resistance to neutralizing antibodies and enhanced transmissibility of SARS-CoV-2 Delta variant

Higher order protein catenation leads to the development of artificial antibodies

GPR126 gene may play an essential role in placental development, study reveals

COVID-19 vaccination humoral immune response in individuals with diabetes

Impact of mutations on binding affinity of SARS-CoV-2 variants with ACE2 and existing antibodies

Study may pave the way for a more personalized approach to COVID-19 diagnosis and treatment

Analysis of immunodeficient patients granted REGEN-COV under compassionate use COVID-19 program

Lab Matters host Harriet Gould on building a more connected lab community

The Critical Role of Sample Storage in Drug Discovery and Development

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

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