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Evaluating efficacy of SARS-CoV-2 antivirals in a mouse model

In a recent study posted to the bioRxiv* pre-print server, researchers from Belgium evaluated the efficacy of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antiviral drugs in a severe combined immunodeficient (SCID) mouse model.

18 May 2022

Recombinant protein vaccine stands up to SARS-CoV-2 variants

A study by researchers in Texas describes a mouse model in which a subunit vaccine with alum-CpG adjuvant was tested for its ability to induce a broadly neutralizing antibody response against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

18 May 2022

Researchers test how three mutations work together to produce new SARS-CoV-2 variants

Like storm waves battering a ship, new versions of the SARS-CoV-2 virus have buffeted the world one after another. Recently, scientists keeping tabs on these variants noticed a trend: Many carry the same set of three mutations.

18 May 2022

Study explores COVID-19's lingering impacts on survivors and local communities

A Japanese research team looking at COVID-19's lingering impacts on survivors and local communities found that having a mild case of COVID-19, smoking status, comorbidities, or your sex aren't significant predictors to tell if you are less likely to develop long-term symptoms but age is.

18 May 2022

Scientists report complex mutation pattern of Omicron BA.2

Recently, scientists have studied the mutation profile of SARS-CoV-2 Omicron BA.2 and analyzed its outcome based on the interaction with receptor and/or monoclonal antibodies.

18 May 2022

Only some coronaviruses found to have pandemic-causing potential

In a new study, scientists focused on resolving the mystery of why some coronaviruses have the potential of causing a pandemic while others do not.

18 May 2022

Gestational diabetes mellitus in overweight and obese pregnant women may increase COVID-19 severity

Researchers reported that gestational diabetes mellitus and obesity were associated with severe COVID-19.

18 May 2022

Discovery of a potent SARS-CoV-2 RBD specific human monoclonal antibody

A recent article posted to the bioRxiv* preprint server demonstrated structural underpinnings of the neutralization of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variants by 002-S21F2, an extensive SARS-CoV-2 neutralizing antibody.

18 May 2022

Compound found in Datura shows promise as antiviral agent against SARS-CoV-2

Researchers from Naval Medical University have been investigating anisodamine, used in traditional Chinese medicine, to inhibit SARS-CoV-2 infection in cellular models. The study is published in the journal Biochemical and Biophysical Research Communications.

17 May 2022

Exploring mutational energetics and the role of arginine blockers in COVID-19 treatments

A new study aimed to describe the roles of certain specific mutations in SARS-CoV-2 strains, with respect to their ability to conformationally stabilize S-protein structure resulting in enhanced receptor-binding domain ACE2 binding.

17 May 2022

Researchers develop treatment that suppresses mutational escape of SARS-CoV-2

Researchers from Xiamen University have created a new treatment that is less likely to be affected by mutations in the receptor-binding domain of SARS-CoV-2.

17 May 2022

Why do diabetic patients have more severe SARS-CoV-2 infections?

A recent study published in the journal Cell Metabolism illustrated the function of angiotensin-converting enzyme 2 (ACE2) in renal severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection among diabetic patients.

16 May 2022

SARS-CoV-2 Omicron BA.2 differs antigenically from previous variants

Researchers observed that the SARS-CoV-2 Omicron BA.2 variant is immunologically different from other variants, including Omicron BA.1.

16 May 2022

Super-antibody UT28K shows broad-spectrum activity against SARS-CoV-2 variants

A study, published online in the journal mAbs, describes a novel mAb, UT28K, that has promising broadly neutralizing activity against the SARS-CoV-2 virus.

15 May 2022

Artificial proteins as specific and versatile neutralizing binders targeting the spike of SARS-CoV-2

Researchers demonstrated that the biosynthetic proteins called αReps addressing the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) protein could be novel SARS-CoV-2 antivirals

13 May 2022

Researchers identify compounds from Aspergillus that may be effective against SARS-CoV-2

Researchers from Ain Shams University have been exploring the use of compounds isolated from Aspergillus sp. against SARS-CoV-2.

13 May 2022

Development of a novel surface plasmon resonance-based assay to determine kinetics of SARS-CoV-2 spike – human ACE2 interaction

A team of scientists has recently studied the kinetic and thermodynamic characteristics of interaction between human ACE2 and spike receptor-binding domains of different variants of SARS-CoV-2.

13 May 2022

SARS-CoV-2 N-terminal domain modulates S1/S2 cleavage and spike-mediated functions

In a recent study posted to the bioRxiv* preprint server, researchers explored the role of the N-terminal domain (NTD) of the severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) spike (S) protein in SARS-CoV-2 fusion with the host membranes and coronavirus disease 2019 (COVID-19).

12 May 2022

Bayesian viral allele selection for SARS-CoV-2 genomic surveillance

In a recent study posted to the bioRxiv* preprint server, researchers assessed the selection effects in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) using Bayesian viral allele selection.

12 May 2022

Researchers identify cellular serpins as host factors that restrict SARS-CoV-2 infection

Researchers investigated differences in susceptibility between individuals and may have discovered a new opportunity for treatment.

12 May 2022

ACE2 News and Research

Evaluating efficacy of SARS-CoV-2 antivirals in a mouse model

Recombinant protein vaccine stands up to SARS-CoV-2 variants

Researchers test how three mutations work together to produce new SARS-CoV-2 variants

Study explores COVID-19's lingering impacts on survivors and local communities

Scientists report complex mutation pattern of Omicron BA.2

Only some coronaviruses found to have pandemic-causing potential

Gestational diabetes mellitus in overweight and obese pregnant women may increase COVID-19 severity

Discovery of a potent SARS-CoV-2 RBD specific human monoclonal antibody

Compound found in Datura shows promise as antiviral agent against SARS-CoV-2

Exploring mutational energetics and the role of arginine blockers in COVID-19 treatments

Researchers develop treatment that suppresses mutational escape of SARS-CoV-2

Why do diabetic patients have more severe SARS-CoV-2 infections?

SARS-CoV-2 Omicron BA.2 differs antigenically from previous variants

Super-antibody UT28K shows broad-spectrum activity against SARS-CoV-2 variants

Artificial proteins as specific and versatile neutralizing binders targeting the spike of SARS-CoV-2

Researchers identify compounds from Aspergillus that may be effective against SARS-CoV-2

Development of a novel surface plasmon resonance-based assay to determine kinetics of SARS-CoV-2 spike – human ACE2 interaction

SARS-CoV-2 N-terminal domain modulates S1/S2 cleavage and spike-mediated functions

Bayesian viral allele selection for SARS-CoV-2 genomic surveillance

Researchers identify cellular serpins as host factors that restrict SARS-CoV-2 infection

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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