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HIV patients on single-tablet regimen show better outcomes than those taking multiple pills

HIV patients on a single-tablet daily regimen had better treatment retention and viral suppression than patients taking multiple pills, in a study by a Michael E. DeBakey Veterans Affairs Medical Center researcher and his colleagues.

18 May 2018

Study underlines importance of early HIV treatment to avoid brain atrophy

While the human immunodeficiency virus (HIV) has largely dropped from news headlines since the 1990s, at the end of 2016 there were 36.7 million people living with the infection, and of those only 53 per cent had access to treatment.

3 May 2018

Study: 40% of people diagnosed with HIV do not disclose their status in rural Mozambique

Almost 40% of people previously diagnosed with HIV do not disclose their HIV status during diagnosis campaigns, leading to unnecessary retesting. In addition to wasting valuable resources, this phenomenon can distort indicators of progress towards the UNAIDS targets.

2 May 2018

Research findings challenge feasibility of 'shock and kill' approach to cure HIV

Researchers have provided new insight into the cellular processes behind the 'shock and kill' approach to curing HIV, which they say challenges the effectiveness of the treatment.

2 May 2018

New computational framework accurately predicts drug-drug and drug-food interactions

A Korean research team from KAIST developed a computational framework, DeepDDI, that accurately predicts and generates 86 types of drug-drug and drug-food interactions as outputs of human-readable sentences, which allows in-depth understanding of the drug-drug and drug-food interactions.

18 Apr 2018

New long-acting delivery system has potential to lessen side effects from NRTIs

An HIV diagnosis, while no longer constituting a death sentence, brings with it a lifetime, daily regimen of medication to help continually combat the virus.

27 Mar 2018

ACTA trial in AIDS patients with cryptococcal meningitis validates new therapeutic regimens

The results of the ACTA trial were presented at the 9th IAS Conference on HIV Science held in Paris from 23 to 26 July 2017. Professor Thomas Harrison and his colleagues at St George's University of London, the Institut Pasteur in Paris, Paris Descartes University (Hôpital Necker-Enfants Malades), the ANRS site in Cameroon, and the MRC sites in Malawi, Tanzania, and Zambia show in this trial that new therapeutic regimens are of benefit in HIV-infected patients with cryptococcal meningitis.

15 Mar 2018

'Treatment as prevention' method can limit HIV transmission, perspective suggests

A perspective in PLOS Medicine suggests that people with HIV who achieve viral suppression with antiretroviral therapy can avoid sexual transmission of HIV without using condoms, a significant study that lends hope that the "treatment as prevention" method can stop the spread of the HIV infection.

14 Mar 2018

Researchers identify new mechanism to disrupt HIV latency

HIV, the virus that causes AIDS, has a secret life. Though anti-retroviral therapy can reduce its numbers, the virus can hide and avoid both treatments and the body's immune response.

8 Mar 2018

FDA approves new antiretroviral medication for patients with multidrug-resistant HIV

Today, the U.S. Food and Drug Administration approved Trogarzo (ibalizumab-uiyk), a new type of antiretroviral medication for adult patients living with HIV who have tried multiple HIV medications in the past (heavily treatment-experienced) and whose HIV infections cannot be successfully treated with other currently available therapies (multidrug resistant HIV, or MDR HIV).

6 Mar 2018

One-month antibiotic regimen to prevent TB as safe, effective as nine-month therapy for HIV patients

A one-month antibiotic regimen to prevent active tuberculosis (TB) disease was at least as safe and effective as the standard nine-month therapy for people living with HIV, according to the results of a large international clinical trial.

6 Mar 2018

Tele-IPT can help treat depression in people living with HIV

Interpersonal psychotherapy is a common, in-person treatment for depression, but new research from the University of Georgia found that this type of one-on-one therapy can be successfully delivered over the telephone.

1 Feb 2018

Global effort toward HIV cure published in Special Issue of AIDS Research and Human Retroviruses

Researchers have shown that despite effective combined antiretroviral therapy, HIV can hide in the spleen of patients with no detectable HIV in their blood.

27 Jan 2018

Persistent immune activation may contribute to increased risk of CVD in people with HIV

A review of more than 80 studies reveals that changes in the immune cells of people with human immunodeficiency virus (HIV) infection may increase their risk of cardiovascular disease (CVD). The review is published in the journal Physiology.

24 Jan 2018

NIH launches large study to compare treatments for pregnant women with HIV

The National Institutes of Health has launched a large international study to compare the safety and efficacy of three antiretroviral treatment regimens for pregnant women living with HIV and the safety of these regimens for their infants.

24 Jan 2018

GW study uncovers potential obstacle to finding a cure for HIV

The latest "kick-and-kill" research to eliminate the HIV virus uncovered a potential obstacle in finding a cure.

22 Jan 2018

Researchers reveal potential of multivalent antibodies for HIV prevention, treatment and cure

The ability of HIV to mutate has been a major challenge to vaccine development. As the body produces antibodies to target the outer HIV envelope protein, this protein changes, thwarting the circulating antibodies' ability to neutralize it.

18 Jan 2018

Research provides new model to better ascertain HIV mortality rates in Zambia

A new study that seeks to better ascertain HIV mortality rates in Zambia could provide a model for improved national and regional surveillance approaches, and ultimately, more effective HIV treatment strategies.

12 Jan 2018

Gene therapy with CAR T-cells could create long-term immunity from HIV

Through gene therapy, researchers engineered blood-forming stem cells (hematopoietic stem/progenitor cells, or HSPCs) to carry chimeric antigen receptor (CAR) genes to make cells that can detect and destroy HIV-infected cells.

29 Dec 2017

New study suggests young adulthood as most beneficial age for HIV screening

A new study suggests that the most beneficial age for a one-time screening HIV test of the general population would be age 25.

19 Dec 2017