Biochemistry News and Research

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Lipidomics reveals health benefits of switching to plant-based fats

Switching from a diet high in saturated animal fats to one rich in plant-based unsaturated fats affects the fat composition in the blood, which in turn influences long-term disease risk.

11 Jul 2024

Existing drug shows promise for treating common liver disease

The University of Barcelona has led a study that suggests using the drug known as pemafibrate to treat liver disease associated with metabolic disorders, the most common liver pathology in the world, which affects one in four people. The drug has long been marketed in Japan for another use: improving blood lipid levels in patients with hyperlipidaemia, a common condition in diabetics. Now, however, it could help address this serious liver disease, which still has no specific treatment.

11 Jul 2024

Repurposing pemafibrate to treat liver disease associated with metabolic disorders

10 Jul 2024

Click-like chemistry enables rapid development of LNPs for enhanced mRNA delivery

Imagine a scenario where a skilled hacker must upload critical software to update a central server and thwart a potentially lethal virus from wreaking havoc across a vast computer network.

10 Jul 2024

60 years in the making: Nanoparticles revolutionize nucleotide delivery

Researchers trace the 60-year evolution of lipid nanoparticles (LNPs) for nucleic acid delivery, highlighting their potential to revolutionize gene therapy with safer and more effective treatments.

10 Jul 2024

Researchers receive $2 million in grants to advance studies on age-related cognitive impairment

Two University of Oklahoma researchers have been awarded more than $2 million in grants from the Hevolution Foundation to further their studies on age-related cognitive impairment, with an emphasis on improving "health span," or the number of years a person remains healthy.

9 Jul 2024

Trinity College Dublin researchers uncover key to enhancing MRSA vaccine efficacy

Researchers from Trinity College Dublin have taken a leap forward in understanding how we might fight back against the potentially deadly MRSA bacterium.

9 Jul 2024

Ribosomes and ZAK protein spur the cell's initial response to UV radiation damage

In a recent study, researchers at Johns Hopkins Medicine suggest the cell's messenger RNA (mRNA) - the major translator and regulator of genetic material - along with a critical protein called ZAK, spur the cell's initial response to UV radiation damage and play a critical role in whether the cell lives or dies.

2 Jul 2024

Welch Foundation funds UTA’s research into creating new materials for effective drug delivery

With a $300,000 grant, the Welch Foundation is supporting University of Texas at Arlington research into creating new materials to safely and effectively deliver medications to treat diseases such as cancer.

2 Jul 2024

Study finds promising new target for the treatment of Alzheimer's disease

A class of proteins that regulates cell repair and enhances cell growth-signaling systems could be a promising new target for the treatment of Alzheimer's and other neurodegenerative diseases, according to a new study led by researchers at Penn State.

2 Jul 2024

Modulating gene expression using small molecules

The correct functioning of cells relies heavily on the ability to finely control gene expression, a complex process by which the information contained in DNA is copied into RNA to eventually give rise to all the proteins and most of the regulatory molecules in the cell.

2 Jul 2024

New light-activated method targets cancer and inflammatory cells with precision

A new method of precisely targeting troublesome cells for death using light could unlock new understanding of and treatments for cancer and inflammatory diseases, University of Illinois Urbana-Champaign researchers report.

1 Jul 2024

New weakness found in antibiotic-resistant Pseudomonas aeruginosa

Antibiotic resistant bacteria are experts in evolving new strategies to avoid being killed by antibiotics.

1 Jul 2024

Nanorobots with hidden weapons for precision cancer therapy

Researchers at Karolinska Institutet in Sweden have developed nanorobots that kill cancer cells in mice.

1 Jul 2024

Enhancing viral therapy for resistant cancers with a metabolite-drug

When a cancer cell doesn't respond to traditional therapies, doctors may turn to a sort of viral biological warfare, by deploying 'troops' in the form of viral agents that are specifically engineered to target and eliminate cancer cells.

28 Jun 2024

Cell division's hidden safety mechanism may influence cancer growth

Before a cell commits fully to the process of dividing itself into two new cells, it may ensure the appropriateness of its commitment by staying for many hours - sometimes more than a day - in a reversible intermediate state, according to a discovery by researchers at Weill Cornell Medicine. Their revelation of this fundamental feature of biology includes details of its mechanisms and dynamics, which may inform the development of future therapies targeting cancers and other diseases.

27 Jun 2024

Novel genetic predisposition to being overweight or obese identified

Researchers performed a case-control study to compare metabolic changes between individuals homozygous for a loss-of-function genetic variation in small integral membrane protein 1 (SMIM1) and the general population.

25 Jun 2024

UTHealth Houston researchers to study circadian link in severe headaches with $2.4M grant

The link between severe headache disorders headaches and the body's circadian clock in pain timing and thresholds will be studied with a $2.4 million grant from the National Institute of Neurological Disorders and Stroke (NINDS) to UTHealth Houston researchers.

21 Jun 2024

Study uncovers new insights into the main human cold and menthol sensor TRPM8

Chronic pain affects millions worldwide, and current treatments often rely on opioids, which carry risks of addiction and overdose.

21 Jun 2024

Transforming drug discovery with AI

A new AI-powered program will allow researchers to level up their drug discovery efforts.

21 Jun 2024

Biochemistry News and Research

Lipidomics reveals health benefits of switching to plant-based fats

Existing drug shows promise for treating common liver disease

Repurposing pemafibrate to treat liver disease associated with metabolic disorders

Click-like chemistry enables rapid development of LNPs for enhanced mRNA delivery

60 years in the making: Nanoparticles revolutionize nucleotide delivery

Researchers receive $2 million in grants to advance studies on age-related cognitive impairment

Trinity College Dublin researchers uncover key to enhancing MRSA vaccine efficacy

Ribosomes and ZAK protein spur the cell's initial response to UV radiation damage

Welch Foundation funds UTA’s research into creating new materials for effective drug delivery

Study finds promising new target for the treatment of Alzheimer's disease

Modulating gene expression using small molecules

New light-activated method targets cancer and inflammatory cells with precision

New weakness found in antibiotic-resistant Pseudomonas aeruginosa

Nanorobots with hidden weapons for precision cancer therapy

Enhancing viral therapy for resistant cancers with a metabolite-drug

Cell division's hidden safety mechanism may influence cancer growth

Novel genetic predisposition to being overweight or obese identified

UTHealth Houston researchers to study circadian link in severe headaches with $2.4M grant

Study uncovers new insights into the main human cold and menthol sensor TRPM8

Transforming drug discovery with AI

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