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Antibiotic choices critical for elderly with bloodstream infections

Failure to treat patients with bacteremia with an appropriate antibiotic is particularly harmful in elderly patients, report researchers.

8 Nov 2012

Encouraging results from Gilead’s TAF Phase 2 trial on HIV-1 infection

Gilead Sciences, Inc. today announced that a Phase 2 clinical trial evaluating tenofovir alafenamide fumarate, an investigational novel prodrug of tenofovir for the treatment of HIV-1 infection, met its primary objective.

1 Nov 2012

LVEDP-guided hydration effectively prevents CI-AKI in patients undergoing cardiac catheterization

A hydration regimen tailored to the patient's fluid status was effective in reducing damage to kidneys in patients undergoing cardiac catheterization, according to a study presented at the 24th annual Transcatheter Cardiovascular Therapeutics (TCT) scientific symposium, sponsored by the Cardiovascular Research Foundation. TCT is the world's premier educational meeting specializing in interventional cardiovascular medicine.

26 Oct 2012

Warning against colloids in fluid resuscitation

Hydroxyethyl starch offers no benefits over saline for fluid resuscitation in critically ill patients and may have renal consequences, shows a randomized trial.

23 Oct 2012

Phase 3 study of INLYTA fails to meet primary endpoint in treatment-naïve patients with RCC

Pfizer Inc. announced today that a Phase 3 study of INLYTA (axitinib) did not meet its primary endpoint of demonstrating statistically significantly longer progression-free survival, versus sorafenib, in treatment-naïve patients with advanced renal cell carcinoma.

18 Oct 2012

Chloride-restrictive intravenous fluids reduce risk for kidney injury

The restrictive use of chloride in intravenous fluids reduces the risk for acute kidney injury and renal replacement therapy, research shows.

18 Oct 2012

Chloride-restrictive intravenous strategy may decrease incidence of AKI among critically ill patients

In a pilot study assessing the effect of different levels of chloride in intravenous fluids administered to critically ill patients in an intensive care unit, restricting the amount of chloride administration was associated with a significant decrease in the incidence of acute kidney injury and the use of renal replacement therapy, according to a study in the October 17 issue of JAMA.

17 Oct 2012

Two novel GFR equations predict kidney function in elderly

Researchers report that two “new” equations may accurately measure kidney function in elderly individuals with nonsevere kidney disease.

9 Oct 2012

Trevena reports completion of TRV027 Phase 2a study in advanced heart failure patients

Trevena, Inc., the leader in the discovery and development of G-protein coupled receptor (GPCR) biased ligands, today announced that it has successfully completed a Phase 2a study on the hemodynamic effects of TRV027 in patients with advanced heart failure with reduced ejection fraction.

8 Oct 2012

Chronic kidney disease independently increases mortality risk

Findings from two meta-analyses published in The Lancet show that patients with chronic kidney disease are at high risk for death and end-stage renal disease even if they do not have comorbid hypertension or diabetes.

4 Oct 2012

New mathematical formulas can evaluate kidney function with age

Within the framework of a Berlin cohort study, scientists from Charité - Universitätsmedizin Berlin have succeeded in developing new mathematical formulas that dependently assess kidney function with age.

4 Oct 2012

Prognosis still poor for EVB in cirrhosis

The current standard of care for esophageal variceal bleeding in liver cirrhosis is very effective at controlling bleeding but patient prognosis remains poor, say the authors of an Italian study.

1 Oct 2012

Exelixis announces preliminary results from BRIM7 Phase Ib trial on BRAFV600 mutated MM

Exelixis, Inc. today announced preliminary results from BRIM7, an ongoing Phase Ib trial conducted by Roche and Genentech, Exelixis' collaborator and a member of the Roche Group, of the BRAF inhibitor (BRAFi) vemurafenib in combination with the MEK inhibitor GDC-0973 in patients with locally advanced/unresectable or metastatic melanoma carrying a BRAFV600 mutation.

29 Sep 2012

Concern grows about rice-related arsenic exposure

US children who consume rice have significantly higher levels of urinary arsenic than children who do not, show study results.

26 Sep 2012

Absence of proteinuria good prognostic sign in IgA nephropathy

The presence of normal renal function and minor urinary abnormalities indicates a good long-term prognosis among Caucasian patients with immunoglobulin A nephropathy, say Spanish researchers.

24 Sep 2012

Children and adolescents with high BPA levels more likely to have obesity

In a nationally representative sample of nearly 3,000 children and adolescents, those who had higher concentrations of urinary bisphenol A (BPA), a manufactured chemical found in consumer products, had significantly increased odds of being obese, according to a study in the September 19 issue of JAMA, and theme issue on obesity.

19 Sep 2012

Measures of kidney function may be linked to thrombosis

Estimated glomerular filtration rate and albumin-creatinine ratio are independently associated with venous thromboembolism, research suggests.

18 Sep 2012

Measures of kidney function may be linked to thrombosis

Estimated glomerular filtration rate and albumin-creatinine ratio are independently associated with venous thromboembolism, research suggests.

18 Sep 2012

Long-term prognosis excellent for patients with IgA nephropathy

For patients with a common kidney disease who have normal kidney function and only minor urinary abnormalities at the time of diagnosis, the long-term prognosis is excellent and no special treatments are needed, according to a study appearing in an upcoming issue of the Journal of the American Society of Nephrology.

7 Sep 2012