Exelixis announces preliminary results from BRIM7 Phase Ib trial on BRAFV600 mutated MM

Exelixis, Inc. (NASDAQ:EXEL) today announced preliminary results from BRIM7, an ongoing Phase Ib trial conducted by Roche and Genentech, Exelixis' collaborator and a member of the Roche Group (SIX: RO, ROG; OTCQX: RHHBY), of the BRAF inhibitor (BRAFi) vemurafenib in combination with the MEK inhibitor GDC-0973 in patients with locally advanced/unresectable or metastatic melanoma carrying a BRAFV600 mutation. Rene Gonzalez, M.D., Professor of Medicine and Dermatology and Director of the Melanoma Research Clinics at the University of Colorado Denver, and an investigator on the trial, presented the data today at the European Society for Medical Oncology (ESMO) 2012 Annual Meeting (Abstract #LBA28), which is taking place in Vienna, Austria. The results of the study were also highlighted in an ESMO press briefing.

Roche has disclosed that it intends to evaluate the combination of vemurafenib with GDC-0973 versus vemurafenib in a multicenter, randomized, double-blind, placebo-controlled Phase III trial in previously untreated patients with BRAFV600 mutation positive, unresectable locally advanced or metastatic melanoma.    

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Exelixis, Inc.

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