Cytotoxicity News and Research

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Scientists develop unique CRISPR-based method for more precise, systematic gene tagging

The genome editing tool known as CRISPR/Cas9 has opened many doors for biomedical research by allowing scientists to precisely edit DNA sequences and alter function. The technology offers hope for correcting genetic defects and preventing disease.

24 Oct 2017

Researchers identify cytotoxic nature of two-dimensional black phosphorous

When environmental and soil chemist Baoshan Xing at the University of Massachusetts Amherst began reading in 2014 that a new, two-dimensional material known as layered black phosphorous (BP) was gaining the attention of biomedical researchers for use in drug delivery systems and tumor photothermal therapy, he was both intrigued and concerned.

31 Aug 2017

Cord-blood-derived natural killer cells can be modified to destroy B-cell cancers

Immune cells with a general knack for recognizing and killing many types of infected or abnormal cells also can be engineered to hunt down cells with specific targets on them to treat cancer, researchers at The University of Texas MD Anderson Cancer Center report in the journal Leukemia.

13 Jul 2017

Researchers develop nano-contrast agents for MRI and optical imaging of cancer cells

Researchers from PSG College of Technology, India have developed nano-contrast agents for magnetic resonance imaging (MRI) as well as optical imaging of cancer cells. This report will appear in the forthcoming issue of the journal NANO.

20 Jun 2017

New biosensor rapidly detects tiny concentrations of influenza A virus

Researchers have developed a new, rapid biosensor for the early detection of even tiny concentrations of the human influenza A (H1N1) virus.

30 May 2017

JGU chemists develop technique that reduces toxic effects of cigarettes

Chemists at Johannes Gutenberg University Mainz have developed a technique that reduces the toxic effects of commercially available cigarettes.

30 May 2017

UAB chemists design microcapsules for guided drug delivery system to target solid tumors

Chemists at the University of Alabama at Birmingham have designed triple-threat cancer-fighting polymer capsules that bring the promise of guided drug delivery closer to preclinical testing.

30 Mar 2017

New method of repairing injured bone could lead to powerful treatments for skeletal system injuries

A recent study, affiliated with UNIST has developed a new method of repairing injured bone using stem cells from human bone marrow and a carbon material with photocatalytic properties, which could lead to powerful treatments for skeletal system injuries, such as fractures or periodontal disease.

8 Feb 2017

New stem cell method could lead to powerful treatments for skeletal system injuries

23 Jan 2017

Enzyme identified in baker's yeast can efficiently annihilate leukemia cells

An enzyme identified in Saccharomyces cerevisiae, commonly known as brewer's or baker's yeast, has passed in vitro trials, demonstrating its capacity to kill acute lymphoblastic leukemia (ALL) cells.

18 Jan 2017

Review shows how nanocarriers can solve problems with drug delivery in ocular tissues

Most ophthalmic diseases are usually treated with topically administered drug formulations (e.g. eye drops).

3 Jan 2017

Study suggests possibility for small molecule drug/antibody combinatorial therapy to treat neuroblastoma

A study by a multidisciplinary team of researchers from The Saban Research Institute of Children's Hospital Los Angeles sheds further light on the role of the cytokine TGFβ1 in the growth of neuroblastoma, and suggests the possibility for a small molecule drug/antibody combinatorial therapy to treat this cancer.

12 Oct 2016

Exposure to e-cigarette vapour induces negligible or no oxidative damage to lung epithelial cells

E-cigarette vapour is much less harmful to lung cells than cigarette smoke. Lab tests show that, unlike tobacco smoke, which causes oxidative stress and cell death, e-cigarette vapour does not. Oxidative stress and cell death are driving factors in the development of many smoking-related diseases such as COPD and lung cancer.

5 Oct 2016

Janssen seeks to extend DARZALEX license to benefit more multiple myeloma patients

Janssen-Cilag International NV has announced the submission of a Type II variation application to the European Medicines Agency (EMA), seeking to broaden the existing marketing authorisation for the immunotherapy DARZALEX® (daratumumab) to include treatment of adult patients with relapsed multiple myeloma who have received at least one prior therapy. The expanded indication is based on daratumumab in combination with lenalidomide (an immmunomodulatory agent) and dexamethasone, or bortezomib (a PI) and dexamethasone.

29 Aug 2016

Kobe University researchers develop new technique for high-level genome editing operation

A team involving Kobe University researchers has succeeded in developing 'Target-AID', a genome editing technique that does not cleave the DNA.

26 Aug 2016

ESCMID releases new guidelines on best practices to detect C. difficile infections

The European Society of Clinical Microbiology and Infectious Diseases has just released new guidelines on best practice methods to diagnose Clostridium difficile infection (CDI).

26 Aug 2016

Essential oils could treat inflammation of lung and liver induced by air pollution

Certain ingredients in essential oils made from plants such as cloves, anise, fennel and ylang-ylang could serve as a natural treatment of lung and liver conditions caused by air pollution.

23 Aug 2016

Researchers find promising new therapy for both pediatric and adult cancers

A study conducted at Nationwide Children's Hospital has found that a new chemotherapy is effective against both pediatric and adult cancers, and that it allows other chemotherapies to more readily reach their targets.

28 Jul 2016

NYU dentists receive grant to test whether non-viral gene delivery can effectively treat oral cancer pain

The National Institute of Dental and Craniofacial Research, part of the National Institutes of Health, has awarded Drs. Brian Schmidt and Seiichi Yamano a $1.2M (3-year) grant to test whether their non-viral gene delivery method can effectively and safely treat oral cancer pain.

28 Jun 2016

New study may help unveil structure and behavior of neurotoxic oligomers in Alzheimer's disease

Much of the research on Alzheimer's disease has focused on the amyloid beta protein, which clumps together into sticky fibrils that form deposits in the brains of people with the disease.

13 Jun 2016