Immunosuppression News and Research

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Immunosuppression involves an act that reduces the activation or efficacy of the immune system. Some portions of the immune system itself have immuno-suppressive effects on other parts of the immune system, and immunosuppression may occur as an adverse reaction to treatment of other conditions.

Some tumors use two levels of protection against immune system, shows study

In research published today, Babraham Institute researchers have shown that some tumors use not one but two levels of protection against the immune system.

8 Jun 2018

Researchers discover cascade of immune processes linked to poor outcomes in aggressive breast cancer

Cancer is crafty. To survive and thrive, tumors find a way of thwarting our body's natural systems.

24 May 2018

Researchers find new method to treat severe asthma

Researchers from McMaster University and the Firestone Institute for Respiratory Health at St. Joseph's Healthcare Hamilton, together with colleagues at other partnering institutions, have developed a new method to treat severe asthma.

23 May 2018

Expectant mothers may use RA drugs without increased health risks to unborn babies

A new study led by a team at the Research Institute of the MUHC in Montreal has revealed that pregnant women with rheumatoid arthritis may be able to use certain RA drugs without possible increased health risks to their unborn babies.

17 May 2018

Scientists successfully graft neural precursor cells into spinal cords of syngeneic pigs with no immunosuppression

A major hurdle to using neural stem cells derived from genetically different donors to replace damaged or destroyed tissues, such as in a spinal cord injury, has been the persistent rejection of the introduced material, necessitating the use of complex drugs and techniques to suppress the host's immune response.

10 May 2018

Gene therapy offers potential cure for patients with lipoprotein lipase deficiency

During the first 18 months after treatment with ali-pogene tiparvovec, a gene therapy recently approved in Europe to treat lipoprotein lipase deficiency (LPLD), the first patient to receive the treatment had no abdominal pain or episodes of pancreatitis, following a history of 37 pancreatitis attacks.

2 May 2018

Research leads to new potential treatment for Hereditary Hemorrhagic Telangiectasia

The work of researchers Francesc Viñals and Mariona Graupera at the Bellvitge Biomedical Research Institute - Catalan Institute of Oncology - University of Barcelona, together with Dr. Antoni Riera-Mestre, has led to a new potential treatment for Hereditary Hemorrhagic Telangiectasia or Rendu-Osler Syndrome, a rare disease that affects blood vessels and had no described treatment.

26 Apr 2018

New implantable device furnishes islet cells with their own supply of oxygen

Since the 1960s, researchers have been interested in the possibility of treating type 1 diabetes by transplanting islet cells -- the pancreatic cells that are responsible for producing insulin when blood glucose concentration increases.

25 Apr 2018

Study: Transplanted livers have a protective effect and reduce potential for organ rejection

Transplanted livers change the profile of blood cells in the recipients, reducing the potential for organ rejection, Mayo Clinic research shows.

18 Apr 2018

Analysis reveals decreasing trend in infection-related mortality among kidney transplant recipients

Since the 1990s, the risk of dying from infections after kidney transplantation has dropped by half, according to a recent analysis. The analysis, which appears in an upcoming issue of the Clinical Journal of the American Society of Nephrology, also found that common bacterial infections remain the most frequent cause of infection-related death among transplant recipients.

6 Apr 2018

Researchers successfully graft human neural stem cells into monkeys with spinal cord injuries

Led by researchers at University of California San Diego School of Medicine, a diverse team of neuroscientists and surgeons successfully grafted human neural progenitor cells into rhesus monkeys with spinal cord injuries.

27 Feb 2018

Opioid users have increased risk of invasive pneumococcal diseases

Opioid users have a significantly increased risk of infections severe enough to require treatment at the hospital, such as pneumonia and meningitis, as compared to people who don't use opioids.

13 Feb 2018

Prostate cancer’s gene-determined ‘immune landscape’ dictates tumor progression

The field of immunotherapy - the harnessing of patients' own immune systems to fend off cancer - is revolutionizing cancer treatment today. However, clinical trials often show marked improvements in only small subsets of patients, suggesting that as-yet unidentified variations among tumors result in distinct paths of disease progression and response to therapy.

12 Jan 2018

New first line combination therapy shows promising results in patients with advanced NSCLC

A new combination therapy for the first line treatment of advanced non-squamous non-small-cell lung cancer (NSCLC) improves progression-free survival (PFS), according to results of phase III IMpower150 trial presented at the ESMO Immuno Oncology Congress 2017.

7 Dec 2017

Study provides insights on mechanisms involved in tolerance after kidney transplantation

A new study provides insights on the mechanisms that allow an individual's immune system to accept, rather than reject, a donor kidney. The findings, which appear in an upcoming issue of the Journal of the American Society of Nephrology, point to markers that could be monitored to assess and track the health of organs following transplantation.

1 Dec 2017

Study uncovers key mechanism by which tumors develop resistance to radiation therapy

A Ludwig Cancer Research study has uncovered a key mechanism by which tumors develop resistance to radiation therapy and shown how such resistance might be overcome with drugs that are currently under development.

23 Nov 2017

AstraZeneca’s new precision biologic gets FDA approval to treat severe eosinophilic asthma

AstraZeneca and its global biologics research and development arm, MedImmune, today announced that the US Food and Drug Administration has approved FASENRA (benralizumab) for the add-on maintenance treatment of patients with severe asthma aged 12 years and older, and with an eosinophilic phenotype.

14 Nov 2017

Healthcare professionals most likely to work while sick, study finds

A new study suggests that healthcare professionals (HCPs) should heed to their own advice: stay home when sick.

1 Nov 2017

Gene therapy effectively stabilizes progression of cerebral adrenoleukodystrophy, trial reveals

In a recent clinical trial, a gene therapy to treat cerebral adrenoleukodystrophy (CALD) -- a neurodegenerative disease that typically claims young boys' lives within 10 years of diagnosis -- effectively stabilized the disease's progression in 88 percent of patients, researchers from the Dana-Farber/Boston Children's Cancer and Blood Disorders Center and Massachusetts General Hospital report today.

4 Oct 2017

Rutgers University leadership creates great strides in breakthrough scientific research

Less than a decade ago, the U.S. Department of Defense established the Armed Forces Institute of Regenerative Medicine I with a multimillion dollar grant to focus research centered on regenerative medicine for the treatment of battlefield injuries and selected Rutgers University-New Brunswick to lead the civilian research program.

26 Aug 2017