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Study helps understand the basis of sex differences in SARS-CoV-2 infection

Significant immunological differences between young men and women were shown to mediate sex differences in the responses to the virus that causes COVID-19, according to a collaborative study of nearly 3,000 young, healthy members of the U.S. Marine Corps.

8 Nov 2022

Study identifies novel inhibitors against SARS-CoV-2 main protease

In a recent study posted to the bioRxiv* server, researchers at the University of Arizona screened ~11 million severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease (MPro)-inhibiting small compounds in the ZINC15 database using a structure-based in-silico screening method.

8 Nov 2022

Does vitamin D reduce COVID-19 severity?

A new study examined published studies for a consistent association between vitamin D levels and coronavirus disease 2019 (COVID-19) severity.

8 Nov 2022

Viral whole genome study in the United States identifies ORF-disrupting mutations in monkeypox virus

Researchers used whole genome sequencing to evaluate monkeypox virus samples from Washington and Ohio states in the United States and identified 25 samples with open reading frame (ORF)-disrupting mutations.

7 Nov 2022

Shared genetic effects between the autoimmune disease systemic lupus erythematosus and the clinical consequences of COVID-19

Researchers identified a genetic association signal, via genome-wide association studies, between severe COVID-19 with systemic lupus erythematosus, an autoimmune disease.

7 Nov 2022

Fermented dairy products can improve gut mucosal immunity

In a recent study published in the journal Immunology Letters, researchers assessed the role of fermented dairy products and dairy starters in modulating gut mucosal immunity.

3 Nov 2022

Vaccination with senescent cells could be a possible therapy against cancer

Cancer cells have a series of features that allow the immune system to identify and attack them. However, these same cells create an environment that blocks immune cells and protects the tumor.

3 Nov 2022

Single-nucleus RNA sequencing and spatial transcriptome atlas of COVID-19 livers

Researchers performed single-nucleus RNA sequencing (snRNA-seq) and spatial transcriptomic profiling of livers from deceased coronavirus disease 2019 (COVID-19) patients.

1 Nov 2022

How does the ISG15/ISGylation system modulate Vaccinia virus infection?

Researchers demonstrated how interferon-stimulated gene 15 (ISG15) is involved in the Vaccinia virus (VACV) dissemination.

1 Nov 2022

What are the implications of microbial ecosystems for female reproductive health?

Researchers reviewed the current understanding of the composition and temporal dynamics of microbial niches in the female reproductive tract.

31 Oct 2022

Novel nanotechnology triggers potent therapeutic anti-tumor immune responses against multiple cancers

A Ludwig Cancer Research study has developed a novel nanotechnology that triggers potent therapeutic anti-tumor immune responses and demonstrated its efficacy in mouse models of multiple cancers.

28 Oct 2022

The epigenetic alterations of monocytes in severe COVID-19

Researchers performed DNA methylation analysis on monocytes in the peripheral blood samples obtained from severe COVID-19 patients.

28 Oct 2022

Association of COVID-19 severity with nasopharyngeal fungal colonization and interleukin-17 induction

Researchers evaluated the concurrent colonization of fungi in the nasopharynx of severe COVID-19 patients.

28 Oct 2022

Long COVID, a new clinical entity constantly evolving

Researchers discuss the epidemiology, diagnosis, pathogenesis, and treatment of long COVID.

27 Oct 2022

Advanced type of nanoparticle could help fight hard-to-treat cancers

Nanoparticles, or tiny molecules that can deliver a payload of drug treatments and other agents, show great promise for treating cancers.

27 Oct 2022

Rare variants of type I IFN immunity genes could underlie life-threatening COVID-19

Researchers assessed whether loss-of-function variants of type I interferon immunity genes are associated with life-threatening COVID-19.

27 Oct 2022

Study reveals conserved and divergent host responses to infections with SARS-CoV-2 variants of concern

Researchers analyzed the phenotypes of the SARS-CoV-2 variants of concern (VOCs), the molecular responses to infections from these VOCs, and the evolving virus-host interactions using a comparative genomic and proteomic approach.

26 Oct 2022

A review of emerging pediatric respiratory viruses

Respiratory viruses continue to be a leading cause of childhood morbidity and mortality.

26 Oct 2022

New approach to immunotherapy provokes a robust anti-tumor immune response in preclinical models

A new approach to cancer immunotherapy that uses one type of immune cell to kill another - rather than directly attacking the cancer - provokes a robust anti-tumor immune response that shrinks ovarian, lung, and pancreatic tumors in preclinical disease models, according to researchers at the Icahn School of Medicine at Mount Sinai in New York.

25 Oct 2022

The Black Death may have influenced the evolution of genes involved in immune responses against pathogens

Researchers gathered empirical evidence that past pandemics due to infectious pathogens shaped the present-day susceptibility of humans to diseases, such as autoimmune diseases.

24 Oct 2022

Interferon News and Research

Study helps understand the basis of sex differences in SARS-CoV-2 infection

Study identifies novel inhibitors against SARS-CoV-2 main protease

Does vitamin D reduce COVID-19 severity?

Viral whole genome study in the United States identifies ORF-disrupting mutations in monkeypox virus

Shared genetic effects between the autoimmune disease systemic lupus erythematosus and the clinical consequences of COVID-19

Fermented dairy products can improve gut mucosal immunity

Vaccination with senescent cells could be a possible therapy against cancer

Single-nucleus RNA sequencing and spatial transcriptome atlas of COVID-19 livers

How does the ISG15/ISGylation system modulate Vaccinia virus infection?

What are the implications of microbial ecosystems for female reproductive health?

Novel nanotechnology triggers potent therapeutic anti-tumor immune responses against multiple cancers

The epigenetic alterations of monocytes in severe COVID-19

Association of COVID-19 severity with nasopharyngeal fungal colonization and interleukin-17 induction

Long COVID, a new clinical entity constantly evolving

Advanced type of nanoparticle could help fight hard-to-treat cancers

Rare variants of type I IFN immunity genes could underlie life-threatening COVID-19

Study reveals conserved and divergent host responses to infections with SARS-CoV-2 variants of concern

A review of emerging pediatric respiratory viruses

New approach to immunotherapy provokes a robust anti-tumor immune response in preclinical models

The Black Death may have influenced the evolution of genes involved in immune responses against pathogens

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