Metabolic Disorders News and Research

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Immune system signaling molecule promotes the production of energy-burning 'beige fat'

An immune signal promotes the production of energy-burning "beige fat," according to a new study publishing August 5th in the open-access journal PLOS Biology by Zhonghan Yang of Sun Yat-Sen University, Guangzhou, China, and colleagues.

5 Aug 2021

Newborn screening and early treatment for spinal muscular atrophy can save both lives and money

Gene therapy for spinal muscular atrophy might have a high up-front price tag. But by screening and treating infants early, the therapy can save both lives and money in the long term.

4 Aug 2021

UVA researchers overturn conventional wisdom on action of key hormone receptors within cells

Researchers at the University of Virginia School of Medicine have overturned conventional wisdom on the workings of vital hormone receptors within cells, a finding that could boost drug development for diabetes and related metabolic disorders, cancer and other diseases.

31 Jul 2021

Untargeted metabolomics profiling can improve diagnosis of metabolic disorders in newborns

A team led by researchers at Baylor College of Medicine found that a screening method known as untargeted metabolomics profiling can improve the diagnostic rate for inborn errors of metabolism, a group of rare genetic conditions, by about seven-fold when compared to the traditional metabolic screening approach.

12 Jul 2021

How do host factors like the lung microbiome aid in SARS‐CoV‐2 infection?

A new article has been published in Cellular and Molecular Lifesciences, which focuses on the connection between host factors and the worsening of the COVID-19. Further, the impact of the virus on the host’s microbiome and secondary infection has also been studied.

8 Jul 2021

Rare genetic variants have a big impact on the risk of developing type 2 diabetes

Scientists at the University of Cambridge have identified rare genetic variants - carried by one in 3,000 people - that have a larger impact on the risk of developing type 2 diabetes than any previously identified genetic effect.

7 Jul 2021

Fecal transplant and fiber supplementation can benefit patients with obesity-related metabolic syndrome

A transplant of healthy gut microbes followed by fiber supplements benefits patients with severe obesity and metabolic syndrome, according to University of Alberta clinical trial findings published today in Nature Medicine.

6 Jul 2021

Study shows effects of COVID-19 pandemic on the health of women aged 50 to 70 years

In a study involving 34 women aged 50-70, researchers at the University of São Paulo (USP) in Brazil performed objective measurements of the impact on the subjects' health of the decrease in physical activity observed during the period of social distancing and isolation imposed by COVID-19.

30 Jun 2021

Lowering iron content in fat cells prevented mice from gaining excess weight

Lowering iron content in fat cells prevented mice fed a high-fat diet from gaining excess weight and developing associated health problems by limiting the amount of lipids absorbed by the intestines, UT Southwestern scientists report in a new study. The findings, published online in Cell Metabolism, could eventually lead to new strategies to protect people against obesity and related diseases.

29 Jun 2021

Researchers discover a new mechanism controlling satiation

Researchers from the Turku PET Centre and Technical University of Munich have discovered a new mechanism controlling satiation. According to the recently published study, the hormone secretin induces satiation by activating brown adipose tissue.

22 Jun 2021

Western diet increases COVID-19 severity in a hamster model

Researchers have shown that a Western diet may affect viral replication, disease severity, and immune protection following infection with SARS-CoV-2.

21 Jun 2021

Alkaloids show potential as treatments for COVID-19

To further study these organic compounds, researchers from Kermanshah University of Medical Sciences, Iran, and Universidad de Santiago de Chile, Chile, reviewed the role of alkaloids as a potential antiviral, specifically against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). They presented the chemistry, plant sources, and antiviral effects of alkaloids and their anti-SARS-CoV-2 effect.

15 Jun 2021

Study explores therapeutic potential of exploiting autophagy cascade against COVID-19

Researchers recently reviewed current knowledge on links between autophagy and coronaviruses and how this knowledge can be used to repurpose autophagy modulators as potential treatment options for COVID-19. The review is published in the journal Frontiers in Microbiology.

7 Jun 2021

Researchers develop new method for sequencing single cells in an efficient manner

RNA sequencing is a powerful technology for studying cells and diseases. In particular, single-cell RNA sequencing helps uncover the heterogeneity and diversity of our body.

1 Jun 2021

OCD linked to higher stroke risk in later life

New findings indicate that the risk of developing ischemic strokes is increased in people with obsessive-compulsive disorder (OCD).

27 May 2021

Decreasing activity of ZMPSTE24 protease with age and comorbidities may make elderly COVID-19 patients vulnerable

Studies have shown that circulating levels of PAI-1, the coagulation cascade activator, are considerably higher in COVID-19 patients with severe respiratory illness compared to patients with bacterial-sepsis and acute respiratory distress syndrome (ARDS). Hence the increase in PAI-1 levels is recognized as an early marker of endothelial dysfunction in COVID-19 patients.

23 May 2021

New study shows that pets and their owners diet together

Keto, gluten-free, organic: If a pet owner is on a specific diet, chances are their dog is on it, too, a new U of G study reveals. But when it comes to a grain-free diet, owners seem to choose it more for their dogs than themselves, the study also found.

20 May 2021

Metabolic Disorders News and Research

Immune system signaling molecule promotes the production of energy-burning 'beige fat'

Newborn screening and early treatment for spinal muscular atrophy can save both lives and money

UVA researchers overturn conventional wisdom on action of key hormone receptors within cells

Untargeted metabolomics profiling can improve diagnosis of metabolic disorders in newborns

How do host factors like the lung microbiome aid in SARS‐CoV‐2 infection?

Rare genetic variants have a big impact on the risk of developing type 2 diabetes

Fecal transplant and fiber supplementation can benefit patients with obesity-related metabolic syndrome

Study shows effects of COVID-19 pandemic on the health of women aged 50 to 70 years

Lowering iron content in fat cells prevented mice from gaining excess weight

Researchers discover a new mechanism controlling satiation

Western diet increases COVID-19 severity in a hamster model

Alkaloids show potential as treatments for COVID-19

Study explores therapeutic potential of exploiting autophagy cascade against COVID-19

Researchers develop new method for sequencing single cells in an efficient manner

OCD linked to higher stroke risk in later life

Decreasing activity of ZMPSTE24 protease with age and comorbidities may make elderly COVID-19 patients vulnerable

New study shows that pets and their owners diet together

Girls more likely to develop metabolic alterations associated with obesity than boys

Prenatal POP exposure may increase the risk of metabolic disorders in adolescence

New method could be used to develop more effective treatments for cancer, metabolic disorders

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