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Dual CRISPR-Cas3 is a promising tool to induce a gigantic genomic deletion and restore dystrophin protein

Researchers evaluated the use of a dual clustered regularly interspaced short palindromic repeats (CRISPR)-Cas3 system.

29 Aug 2023

Study unveils previously unknown urinary biomarkers, revolutionizing early detection and treatment of viral infections like COVID-19

This recent study identifies new urinary biomarkers for detecting acute COVID-19 using spectroscopic analysis. The findings reveal that these biomarkers could offer valuable tools for early diagnosis, understanding the severity of the disease, and possibly contribute to endogenous immunological defense mechanisms against SARS-CoV-2.

29 Aug 2023

Could automated, saliva-based PCR testing be the future of COVID-19 surveillance?

In a large-scale study funded by Kings College London, researchers successfully implemented an automated PCR-based testing program for SARS-CoV-2 using saliva samples from asymptomatic students and staff. The system achieved 85% sensitivity and 100% specificity, provided rapid results within eight hours, and offered a cost-effective and scalable approach to community surveillance of COVID-19.

28 Aug 2023

A comprehensive online resource allows for the exploration of interactions between mutational signatures and topographical features across human cancer

An online resource for studying the relationship between mutational signatures and topographical characteristics across human cancer.

28 Aug 2023

The potential of targeting mitochondria-associated programmed cell death for age-related disease treatment

The review summarized the involvement of mitochondria in age-related disease progression and highlighted its potential as a therapeutic target of these diseases.

28 Aug 2023

Insights into COVID-19's aftermath: 2-year study examines lasting health effects

Researchers comprehensively assessed the risks and burdens of post-acute sequelae of coronavirus disease 2019.

28 Aug 2023

Two small molecule inhibitors can help improve precision, efficiency of CRISPR-Cas9 gene editing

A new study published in Nature Communications demonstrates how small molecule inhibitors can be used to improve the precision and efficiency of CRISPR-Cas9 gene editing.

25 Aug 2023

Small molecule inhibitor of the NLRP3 inflammasome for treating autoinflammatory diseases

Researchers described the preclinical profile of JT002, a novel and orally bioavailable small molecule inhibitor of the NLRP3 inflammasome.

24 Aug 2023

Differences in immune responses to IL-6 inhibition therapy between male and female COVID-19 patients

Researchers investigated whether anti‑interleukin 6 monoclonal antibodies were related to heterogenous treatment effects between male and female COVID-19 patients.

24 Aug 2023

How does COVID-19 influence your gut microbiota?

Researchers analyzed the fecal microbiota composition in COVID-19 patients in comparison to non-COVID-19 controls.

23 Aug 2023

The gut microbiota associated with prediabetes and treatment naïve type 2 diabetes patients

The gut-inhabiting bacteria in pre-type 2 diabetes (pre-T2D) patients.

23 Aug 2023

The outcome of invasive S. pyogenes infection is regulated by an interplay between human STING genotype and bacterial NADase activity

The interplay between human STING genotype and bacterial NADase activity.

22 Aug 2023

Microbiome-directed foods boost child nutrition

Researchers reconstructed gut bacterial genomes.

21 Aug 2023

The interplay between the microbiota, the epigenome, and nutrition among obese adults during behavioral weight reduction

Study evaluated associations between gut microbiome (MB), deoxyribonucleic acid (DNA) methylation (DNAme), and nutrition.

21 Aug 2023

Host viral burden increases with age, is reduced by vaccination, and is influenced by vaccination status and viral variant interplay

The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants on host viral burden.

18 Aug 2023

Researchers develop new rapid and reliable method for SARS-CoV-2 detection

Commercially available mass spectrometers can reliably detect the SARS-CoV-2 coronavirus. In the journal "Clinical proteomics" researchers from the Martin Luther University Halle-Wittenberg (MLU) present a new method which employs equipment that is already being used in hospitals and laboratories to detect bacterial and fungal infections.

16 Aug 2023

Polymerase News and Research

Dual CRISPR-Cas3 is a promising tool to induce a gigantic genomic deletion and restore dystrophin protein

Study unveils previously unknown urinary biomarkers, revolutionizing early detection and treatment of viral infections like COVID-19

Could automated, saliva-based PCR testing be the future of COVID-19 surveillance?

A comprehensive online resource allows for the exploration of interactions between mutational signatures and topographical features across human cancer

The potential of targeting mitochondria-associated programmed cell death for age-related disease treatment

Insights into COVID-19's aftermath: 2-year study examines lasting health effects

Two small molecule inhibitors can help improve precision, efficiency of CRISPR-Cas9 gene editing

Small molecule inhibitor of the NLRP3 inflammasome for treating autoinflammatory diseases

Differences in immune responses to IL-6 inhibition therapy between male and female COVID-19 patients

How does COVID-19 influence your gut microbiota?

The gut microbiota associated with prediabetes and treatment naïve type 2 diabetes patients

The outcome of invasive S. pyogenes infection is regulated by an interplay between human STING genotype and bacterial NADase activity

Microbiome-directed foods boost child nutrition

The interplay between the microbiota, the epigenome, and nutrition among obese adults during behavioral weight reduction

Host viral burden increases with age, is reduced by vaccination, and is influenced by vaccination status and viral variant interplay

Researchers develop new rapid and reliable method for SARS-CoV-2 detection

Next-generation sequencing provides novel insights into the mechanisms underlying autism and myotonic muscular dystrophy

Evolutionary roadmap revealed: How SARS-CoV-2 adapted and evolved over three years

Study uses genomic data to produce high-resolution serial interval estimates for COVID-19

Is COVID-19 self-testing effective?

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

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