Immune System News and Research

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Researchers seek to quantify immunogenicity of COVID vaccines in immunocompromised patients

Evidence continues to mount that vaccination against COVID-19, most notably the Pfizer and Moderna vaccines, produces robust, durable protection in the vast majority of recipients.

2 Jul 2021

Experts reveal ways of dealing with fear and provide scope for confidence

Terrorism, climate change and now a pandemic - worries and fears shape the everyday lives of many people. The latest issue of the Science Magazine BfR2GO from the German Federal Institute for Risk Assessment (BfR) is dedicated to fear, while at the same time embarking on a search for confidence. Scientists from many spheres have their chance to speak and categorize the concepts in a clear way.

2 Jul 2021

Vaccines grown in eggs can lead to an off-target antibody response

Over years of studying antibody responses against the flu in the Wilson lab at the University of Chicago, researchers kept coming up with a strange finding: antibodies that seemed to bind not only to the flu virus but to every virus the lab could throw at them.

2 Jul 2021

Is there a link between circadian rhythms and COVID-19 severity?

This study showed that the time of day of SARS-CoV-2 infection could impact the severity of the viral infection and the host immune response.

1 Jul 2021

Mutations in the spike proteins of SARS-CoV-2 select for amino acid changes, increasing protein stability

A team of researchers recently demonstrated that mutations in the S protein of SARS-CoV-2 select for amino acid changes that result in a more stable protein than would otherwise be expected.

1 Jul 2021

Cryo-EM structure of neutralizing antibody 5-7 in complex with SARS CoV-2 spike

Researchers from the US recently reported the 3.7 Å resolution cryo-EM structure of an NTD-directed neutralizing antibody 5-7 that forms a complex with SARS-CoV-2 spike protein. They also presented the neutralization data against VOC and studied the recognized epitope.

1 Jul 2021

High levels of neutrophil extracellular traps found in airways of severely ill Covid-19 patients

When researchers at Lund University in Sweden performed advanced analyses of sputum from the airways of severely ill Covid-19 patients, they found high levels of neutrophil extracellular traps (NETs).

1 Jul 2021

Study highlights the importance of T cell cross reactivity in stopping severe COVID-19 infections

Researchers at La Jolla Institute for Immunology have found that T cells from people who have recovered from COVID-19 or received the Moderna or Pfizer-BioNTech vaccines are still able to recognize several concerning SARS-CoV-2 variants.

1 Jul 2021

Scientists uncover features of T cells that distinguish fatal COVID-19 from non-fatal cases

While vaccines are doing a remarkable job of slowing the COVID-19 pandemic, infected people can still die from severe illness and new medications to treat them have been slow to arise.

1 Jul 2021

Lung cancer patients should be screened for MET oncogene amplification, research suggests

Research by investigators at Mayo Clinic Cancer Center suggests that physicians should screen patients with lung cancer for MET amplification/overexpression before determining a treatment strategy.

1 Jul 2021

Study evaluates neutralizing antibody responses elicited by the Pfizer/BioNTech COVID-19 vaccine

A recent Diagnostics study discusses the specific antibody response that occurred in individuals after they had received the SARS-CoV-2 vaccine.

1 Jul 2021

Damage to children’s education — and their health — could last a lifetime

Before the pandemic, 16-year-old Na'ryen Cayou had everything he needed. He had his own room. A partial scholarship to a boys' prep school. A spot playing trombone in the marching band, performing in parades all over New Orleans.

1 Jul 2021

New malaria vaccine is undergoing Phase 1 trials but current results show it provides strong and long-lasting protection

A new malaria vaccine could be the breakthrough in developing an effective and lasting treatment.

1 Jul 2021

Alpha variant mutations help SARS-CoV-2 overcome evolutionary weaknesses

The study, published in the journal Cell Reports, showed that the mutations in the virus, particularly the deletion of two amino acids H69/V70 seen in the Alpha variant (B.1.1.7), enables the virus to overcome weaknesses as it evolves.

30 Jun 2021

Researchers turn to machine learning to predict when immunotherapy will be effective

When it comes to defense, the body relies on attack thanks to the lymphatic and immune systems. The immune system is like the body's own personal police force as it hunts down and eliminates pathogenic villains.

30 Jun 2021

New research receives $2 million grant to determine if meningitis, sepsis increase Alzheimer's risk

The role of peripheral and brain infections in the development of Alzheimer's disease is the focus of new research at The University of Texas Health Science Center at Houston, funded with a $2 million grant from the National Institutes of Health.

30 Jun 2021

New method to transport RNA-based drugs to subpopulation of immune cells

Tel Aviv University's groundbreaking technology may revolutionize the treatment of cancer and a wide range of diseases and medical conditions. In the framework of this study, the researchers were able to create a new method of transporting RNA-based drugs to a subpopulation of immune cells involved in the inflammation process, and target the disease-inflamed cell without causing damage to other cells.

30 Jun 2021

NIH-funded adjuvant improves the efficacy India's COVID-19 vaccine

An adjuvant developed with funding from the National Institutes of Health has contributed to the success of the highly efficacious COVAXIN COVID-19 vaccine, which roughly 25 million people have received to date in India and elsewhere.

30 Jun 2021

Widespread SARS-CoV-2 mutation escapes vaccine- and infection-induced CD8 T-cell responses

Researchers in the UK have warned that a widespread mutation that has arisen in the spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) appears to escape recognition by CD8 T-cell responses in both convalescent patients and recipients of the current coronavirus disease 2019 (COVID-19) vaccines.

29 Jun 2021

Six antibody features could be used to identify women at risk of placental malaria

Six antibody characteristics could help scientists identify which pregnant women are at risk of placental malaria infections, finds a study published today in eLife.

29 Jun 2021

Immune System News and Research

Researchers seek to quantify immunogenicity of COVID vaccines in immunocompromised patients

Experts reveal ways of dealing with fear and provide scope for confidence

Vaccines grown in eggs can lead to an off-target antibody response

Is there a link between circadian rhythms and COVID-19 severity?

Mutations in the spike proteins of SARS-CoV-2 select for amino acid changes, increasing protein stability

Cryo-EM structure of neutralizing antibody 5-7 in complex with SARS CoV-2 spike

High levels of neutrophil extracellular traps found in airways of severely ill Covid-19 patients

Study highlights the importance of T cell cross reactivity in stopping severe COVID-19 infections

Scientists uncover features of T cells that distinguish fatal COVID-19 from non-fatal cases

Lung cancer patients should be screened for MET oncogene amplification, research suggests

Study evaluates neutralizing antibody responses elicited by the Pfizer/BioNTech COVID-19 vaccine

Damage to children’s education — and their health — could last a lifetime

New malaria vaccine is undergoing Phase 1 trials but current results show it provides strong and long-lasting protection

Alpha variant mutations help SARS-CoV-2 overcome evolutionary weaknesses

Researchers turn to machine learning to predict when immunotherapy will be effective

New research receives $2 million grant to determine if meningitis, sepsis increase Alzheimer's risk

New method to transport RNA-based drugs to subpopulation of immune cells

NIH-funded adjuvant improves the efficacy India's COVID-19 vaccine

Widespread SARS-CoV-2 mutation escapes vaccine- and infection-induced CD8 T-cell responses

Six antibody features could be used to identify women at risk of placental malaria

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