Preclinical News and Research

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Agenus enters into agreement with Merck for development of therapeutic antibodies

Agenus Inc. announced today that the company has entered into a collaboration and license agreement with Merck, known as MSD outside the United States and Canada, through a subsidiary, for the discovery and development of therapeutic antibodies to immune checkpoints for the treatment of cancer. Under the terms of the agreement, Agenus will discover and optimize fully human antibodies against two undisclosed Merck checkpoint targets using the 4-Antibody Retrocyte Display® platform.

28 Apr 2014

New data from EMD Serono's multiple sclerosis portfolio to be presented at the 66th AAN Annual Meeting

EMD Serono, Inc., a subsidiary of Merck KGaA, Darmstadt, Germany, announced today that new data from the company's multiple sclerosis (MS) portfolio will be presented at the American Academy of Neurology's 66th Annual Meeting, taking place from April 26 – May 3, in Philadelphia, PA.

26 Apr 2014

Promising new approach targets cancer protein to slow tumor growth

Sometimes a full-on assault isn't the best approach when dealing with a powerful enemy. A more effective approach, in the long run, may be to target the support system replenishing the supplies that keep your foe strong and ready for battle.

26 Apr 2014

Lilly launches second medical student education program

Eli Lilly and Company announced today the launch of another medical student education program, an internship for aspiring physicians.

26 Apr 2014

Georgia State researcher receives grant to develop novel therapeutics against RSV infection

Dr. Richard Plemper, a professor in the new Institute for Biomedical Sciences at Georgia State University, has received a five-year, $2.83 million federal grant to develop novel therapeutics against Respiratory Syncytial Virus (RSV) infection.

25 Apr 2014

Development of nervous system may play pivotal role in spread of breast cancer

New research led by a scientist at the University of York reveals that a process that forms a key element in the development of the nervous system may also play a pivotal role in the spread of breast cancer.

25 Apr 2014

New ultrasound device could help identify arterial plaque that cause heart attack, stroke

Researchers from North Carolina State University and the University of North Carolina at Chapel Hill have developed a new ultrasound device that could help identify arterial plaque that is at high risk of breaking off and causing heart attack or stroke.

25 Apr 2014

Zenalux, RPCI collaborate to enhance Zenascope system to detect oral cancers at an early stage

Zenalux Biomedical, Inc., a leader in biophotonic diagnostics, is working with Roswell Park Cancer Institute to further enhance its flagship Zenascope™ product by adding a high-resolution camera to the system.

25 Apr 2014

Research grants could improve patients' recovery from athletic and nonathletic injuries

Two orthopedic organizations have presented Beaumont Health System with prestigious, competitive research grants that could improve patients' recovery from both athletic and nonathletic injuries.

23 Apr 2014

HOPA Membership Awards winners for 2014 announced at 10th Annual Conference

The Hematology/Oncology Pharmacy Association (HOPA) announced the recipients of the 2014 HOPA Membership Awards at its 10th Annual Conference in March. HOPA Membership Awards recognize members who have shown outstanding achievement in their field.

23 Apr 2014

NeuroPhage engineers series of molecules with potential to treat most neurodegenerative diseases

Researchers from NeuroPhage Pharmaceuticals, Inc. have engineered a series of molecules with the potential to treat most neurodegenerative diseases that are characterized by misfolded proteins, such as Alzheimer's, Parkinson's and Huntington's diseases.

23 Apr 2014

Scientists uncover key mechanism that regulates nerve cell growth in damaged nervous system

New research published today out of the University of Calgary's Hotchkiss Brain Institute uncovers a mechanism to promote growth in damaged nerve cells as a means to restore connections after injury. Dr. Doug Zochodne and his team have discovered a key molecule that directly regulates nerve cell growth in the damaged nervous system.

22 Apr 2014

Synageva announces publication of LAL Deficiency review in Atherosclerosis

Synageva BioPharma Corp., a biopharmaceutical company developing therapeutic products for rare diseases, today announced the publication of an overview of lysosomal acid lipase deficiency (LAL Deficiency) in the online version and an upcoming print edition of Atherosclerosis, the official journal of the European Atherosclerosis Society.

21 Apr 2014

Cyclenium Pharma signs drug discovery and development agreement with Southern Research Institute

Cyclenium Pharma Inc., an emerging pharmaceutical company specializing in the research and development of novel drug candidates based on proprietary macrocyclic chemistry, today announced the signing of a discovery and co-development agreement with Southern Research Institute, a not-for-profit 501(c)(3) scientific research organization founded in 1941.

18 Apr 2014

Scientists develop microbicide gel that prevents transmission of multiple STIs in vagina/rectum in animals

Population Council scientists and their partners have found that their proprietary microbicide gel is safe, stable, and can prevent the transmission of multiple sexually transmitted infections (STIs) in both the vagina and rectum in animals: HIV, herpes simplex virus 2 (HSV-2), and human papillomavirus (HPV).

18 Apr 2014

Agios begins AG-348 Phase 1 study to treat PK deficiency

Agios Pharmaceuticals, Inc., a leader in the fields of cancer metabolism and inborn errors of metabolism (IEM), today announced dose administration of AG-348 in a Phase 1 study in healthy volunteers.

18 Apr 2014

OPKO Health enters into definitive agreement to acquire Inspiro Medical

OPKO Health, Inc. has entered into a definitive agreement to acquire Inspiro Medical Ltd., an Israeli medical device company developing a new platform to deliver small molecule drugs such as corticosteroids and beta agonists or larger molecules to treat respiratory diseases. Inspiro's Inspiromatic is a "smart" easy-to-use dry powder inhaler with several advantages over existing devices.

17 Apr 2014

John Hopkins researchers create novel optical imaging equipment for use on SARRP research platform

Researchers from John Hopkins University have created an innovative piece of optical imaging equipment for use on-board the Xstrahl Small Animal Radiation Research Platform.

From Xstrahl 17 Apr 2014

Neurovive presents new breakthrough on energy regulation at cellular level

NeuroVive, a leading mitochondrial medicine company, is presenting a breakthrough in the company's work on energy regulation at the cellular level.

17 Apr 2014

Genetically modified neural stem cells offer potential treatment for Alzheimer's disease

UC Irvine neurobiologists have found that genetically modified neural stem cells show positive results when transplanted into the brains of mice with the symptoms and pathology of Alzheimer's disease. The pre-clinical trial is published in the journal Stem Cells Research and Therapy, and the approach has been shown to work in two different mouse models.

16 Apr 2014

Preclinical News and Research

Agenus enters into agreement with Merck for development of therapeutic antibodies

New data from EMD Serono's multiple sclerosis portfolio to be presented at the 66th AAN Annual Meeting

Promising new approach targets cancer protein to slow tumor growth

Lilly launches second medical student education program

Georgia State researcher receives grant to develop novel therapeutics against RSV infection

Development of nervous system may play pivotal role in spread of breast cancer

New ultrasound device could help identify arterial plaque that cause heart attack, stroke

Zenalux, RPCI collaborate to enhance Zenascope system to detect oral cancers at an early stage

Research grants could improve patients' recovery from athletic and nonathletic injuries

HOPA Membership Awards winners for 2014 announced at 10th Annual Conference

NeuroPhage engineers series of molecules with potential to treat most neurodegenerative diseases

Scientists uncover key mechanism that regulates nerve cell growth in damaged nervous system

Synageva announces publication of LAL Deficiency review in Atherosclerosis

Cyclenium Pharma signs drug discovery and development agreement with Southern Research Institute

Scientists develop microbicide gel that prevents transmission of multiple STIs in vagina/rectum in animals

Agios begins AG-348 Phase 1 study to treat PK deficiency

OPKO Health enters into definitive agreement to acquire Inspiro Medical

John Hopkins researchers create novel optical imaging equipment for use on SARRP research platform

Neurovive presents new breakthrough on energy regulation at cellular level

Genetically modified neural stem cells offer potential treatment for Alzheimer's disease

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