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COVID-19 vaccination induces transient increase in cellular and antibody responses to S1 antigenic sequence

Scientists have characterized T-cell, B-cell, and IgG responses to S antigenic sequences to evaluate vaccine effectiveness.

13 Oct 2021

Impact of BRCA1 mRNA expression on survival of patients breast and colorectal cancer

Oncotarget published "Opposing effects of BRCA1 mRNA expression on patient survival in breast and colorectal cancer and variations among African American, Asian, and younger patients" which reported that LMNB2 is a chromatin remodeling protein that also plays a role in eukaryotic cell proliferation by organizing the nuclear membrane during mitosis.

13 Oct 2021

How long does natural immunity produced by SARS-CoV-2 infection last?

A new study posted to the bioRxiv* preprint server followed the adaptive immune response in convalescent patients from Swedish and Italian cohorts—which had earlier shown long-lasting adaptive immune responses to the G614 strain—for 15 months. Here, specific antibody levels and neutralizing antibody titers were tested against variants of concern (VOCs).

12 Oct 2021

Researchers uncover how cancer cells use sugar residue to evade the immune system

A team of South Dakota State University chemistry researchers uncovered how cancer cells utilize a simple sugar residue to disguise themselves from the immune system. What they learned will help scientists develop more effective cancer therapeutics.

12 Oct 2021

Rapid measurement of SARS-CoV-2 spike T-cells

Researchers measure SARS-CoV-2 T-cell responses in individuals vaccinated or in those who developed immunity from a prior natural infection.

12 Oct 2021

A survey on computational methods in discovering protein inhibitors of SARS-CoV-2

Researchers review diverse computational methods for drug/inhibitor design and enzymes as potential targets for inhibitors to treat coronaviruses diseases.

12 Oct 2021

A mucoadhesive polymer with anti-SARS-COV-2 activity in vitro and in vivo

The team has evaluated a low molecular weight chitosan derivative as a candidate preventing the viral entry into mammalian nasal epithelial cells to limit the spread of COVID-19.

12 Oct 2021

Taste loss as a COVID-19 symptom: a review

A new review reports that alterations in taste affected about a third of individuals with a COVID-19 diagnosis, with females being affected more than males.

12 Oct 2021

Vaccinated children induced significantly higher antibody titers than naturally SARS-CoV-2 infected children

A recent preprint discusses the antibody response to the nucleic acid vaccines against SARS-CoV-2 when administered to children aged 7-11 years.

12 Oct 2021

Nucleoside modifications suppress the potential of RNA to activate dendritic cells

A new paper shows that human TLR3, TLR7, and TLR8 receptors are activated with naturally occurring RNA, but this is eliminated once modified nucleosides such as m5C, m6A, m5U s2U, or pseudouridine are incorporated.

12 Oct 2021

A new bacterial two-hybrid assay to study SARS-CoV-2 interactome

Recently, scientists have developed a bacterial two-hybrid (B2H) system to study the PPIs of SARS-CoV-2 in a heterologous non-eukaryotic system. This study is available on the bioRxiv* preprint server. Put simply, the B2H system could be used to analyze the SARS-CoV-2 proteome.

11 Oct 2021

Analysis of SARS-CoV-2 Delta variant transmissibility across New England, USA

A recent study compares the transmissibility of the SARS-CoV-2 Alpha and Delta variants in six states across New England in the United States

11 Oct 2021

COVID-19 vaccination elicits broader antibody response to SARS-CoV-2 spike than infection

A recent study demonstrates that antibodies generated in response to mRNA-based COVID-19 vaccination target more epitopes across the spike protein.

11 Oct 2021

An investigation of SARS-CoV-2 infection in diabetic pregnancies

Researchers discuss the basic and clinical science of the potential inter-relationships between diabetes mellitus and COVID-19 in pregnancies.

11 Oct 2021

SARS-CoV-2 immune responses in nursing home residents after full vaccination with Pfizer-BioNTech COVID-19 vaccine

A new study assesses antibody and functional T-cell responses at 6 months after complete vaccination with the Pfizer-BioNTech vaccine.

11 Oct 2021

The role of inhibiting palmitoylation of the SARS-CoV-2 spike protein on viral infectivity

It is demonstrated that palmitoylation of the first five cysteine residues of the C-terminal domain of the SARS-CoV-2 spike protein facilitates cell entry and the formation of syncytia.

11 Oct 2021

Vaccine-induced memory B cells can recognize SARS-CoV-2 variants

Researchers have been investigating the effect that memory B cells produced in individuals who have received an mRNA vaccine have against SARS-CoV-2 variants.

11 Oct 2021

Research finds different antibody responses following COVID vaccination and natural infection

A new study published in the journal Nature attempted to investigate memory B cell evolution 5 months after vaccination with mRNA vaccines such as Moderna (mRNA-1273) or Pfizer-BioNTech (BNT162b2) in SARS-CoV-2 naïve individuals. The study explored various aspects of memory B cell antibody response like neutralizing response, affinity, epitope targeting, and neutralizing breadth.

10 Oct 2021

Phase I clinical trial of two Cuban recombinant protein COVID-19 vaccines

The results of Phase I clinical trials for two new COVID-19 vaccine candidates based on recombinant RDB proteins are reported.

10 Oct 2021

What impact does temperature have on SARS-CoV-2 M protein dynamics?

In a recent study, the structural dynamics of the SARS-CoV-2 M protein are studied at temperatures of 10-50 ˚C using molecular dynamics simulations.

10 Oct 2021

Receptor News and Research

COVID-19 vaccination induces transient increase in cellular and antibody responses to S1 antigenic sequence

Impact of BRCA1 mRNA expression on survival of patients breast and colorectal cancer

How long does natural immunity produced by SARS-CoV-2 infection last?

Researchers uncover how cancer cells use sugar residue to evade the immune system

Rapid measurement of SARS-CoV-2 spike T-cells

A survey on computational methods in discovering protein inhibitors of SARS-CoV-2

A mucoadhesive polymer with anti-SARS-COV-2 activity in vitro and in vivo

Taste loss as a COVID-19 symptom: a review

Vaccinated children induced significantly higher antibody titers than naturally SARS-CoV-2 infected children

Nucleoside modifications suppress the potential of RNA to activate dendritic cells

A new bacterial two-hybrid assay to study SARS-CoV-2 interactome

Analysis of SARS-CoV-2 Delta variant transmissibility across New England, USA

COVID-19 vaccination elicits broader antibody response to SARS-CoV-2 spike than infection

An investigation of SARS-CoV-2 infection in diabetic pregnancies

SARS-CoV-2 immune responses in nursing home residents after full vaccination with Pfizer-BioNTech COVID-19 vaccine

The role of inhibiting palmitoylation of the SARS-CoV-2 spike protein on viral infectivity

Vaccine-induced memory B cells can recognize SARS-CoV-2 variants

Research finds different antibody responses following COVID vaccination and natural infection

Phase I clinical trial of two Cuban recombinant protein COVID-19 vaccines

What impact does temperature have on SARS-CoV-2 M protein dynamics?

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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