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Proteogenomics reveals new target for beating drug resistance in acute myeloid leukemia

Doctors have nearly a dozen new targeted drugs to treat patients with acute myeloid leukemia, or AML, yet three of four patients still die within five years.

2 Feb 2024

Engrailed-1 protein promotes pancreatic cancer progression and metastasis

Pancreatic cancer is the No. 3 cause of cancer-related deaths in the United States, and only 12% of patients survive five years after being diagnosed.

2 Feb 2024

NAEC develops updated guidelines to improve quality of care for people with severe epilepsy

The National Association of Epilepsy Centers (NAEC) has developed updated guidelines that outline the comprehensive services and resources epilepsy centers should provide to improve quality of care for people whose epilepsy is not well-controlled.

2 Feb 2024

Unveiling HIV's "latch": New study reveals key to blocking infection

As the HIV virus glides up outside a human cell to dock and possibly inject its deadly cargo of genetic code, there's a spectacularly brief moment in which a tiny piece of its surface snaps open to begin the process of infection.

2 Feb 2024

CRISPR-Cas9 gene-editing tool repairs defective T cells to treat rare hereditary disease

Some hereditary genetic defects cause an exaggerated immune response that can be fatal. Using the CRISPR-Cas9 gene-editing tool, such defects can be corrected, thus normalizing the immune response, as researchers led by Klaus Rajewsky from the Max Delbrück Center now report in "Science Immunology."

2 Feb 2024

Breakthrough gene-editing therapy transforms lives of patients with a hereditary disorder

A group of patients with a hereditary disorder have had their lives transformed by a single treatment of a breakthrough gene-editing therapy, according to the lead researcher.

2 Feb 2024

New molecule is one step closer to becoming a treatment for Phelan-McDermid syndrome

A molecule created at the University of Auckland is one step closer to becoming a treatment for an extremely rare and severely debilitating neurological disorder called Phelan-McDermid syndrome.

2 Feb 2024

Breakthrough recombinase technology ushers in precise, adaptable gene editing

A team of researchers at the Carl Gustav Carus Faculty of Medicine, TUD Dresden University of Technology, led by Prof. Frank Buchholz, has achieved a major breakthrough in genome editing technology.

1 Feb 2024

Specific epigenetic pathway found to be involved in the development of melanoma drug resistance

One of the major challenges in cancer research and clinical care is understanding the molecular basis for therapeutic resistance as a major cause of long term treatment failures.

1 Feb 2024

X-chromosome inactivation and its role in autoimmune susceptibility in females

Somewhere between 24 and 50 million Americans have an autoimmune disease, a condition in which the immune system attacks our own tissues. As many as 4 out of 5 of those people are women.

1 Feb 2024

Identifying essential genetic regions for gestational diabetes with deep learning and cfDNA sequencing

Gestational diabetes mellitus (GDM) is a prevalent pregnancy complication posing significant health risks to both mothers and their newborns. Early detection and treatment of GDM are crucial to prevent adverse outcomes.

1 Feb 2024

Is there an association between vitamin D, immunocompetence, and aging?

The role of an individual’s immunocompetence in the responsiveness to vitamin D.

1 Feb 2024

The anti-cancer potential of sRNAs isolated from different mushroom species

Study reveals that sRNAs from certain mushrooms, particularly Boletus edulis and Agaricus bisporus, show promising anti-cancer properties, with varying efficacy across different species.

31 Jan 2024

Cerebellum plays key role in exercise-induced anxiety relief

"Only exercise can remove all kinds of doubts," Goethe said. Physical exercise is the lubricant between the body and the mind.

31 Jan 2024

Researchers detect genetic traces of hepatitis E viruses in wastewater

Researchers have identified genetic traces of hepatitis E viruses in almost 73 percent of wastewater samples from North-Rhine Westphalia.

31 Jan 2024

Combination drug treatment could be effective against malignant peripheral nerve sheath tumors

A combination of two cancer drugs could be effective against malignant peripheral nerve sheath tumors (MPNSTs) - soft tissue tumors that are stubbornly resistant to chemotherapy and radiation - according to a laboratory study led by researchers at the Johns Hopkins Kimmel Cancer Center.

31 Jan 2024

Eating up to three daily kimchi servings could reduce obesity risk in men

Eating up to three daily servings of the Korean classic, kimchi, may lower men's overall risk of obesity, while radish kimchi is linked to a lower prevalence of midriff bulge in both sexes, finds research published in the open access journal BMJ Open.

31 Jan 2024

Genetic News and Research

Proteogenomics reveals new target for beating drug resistance in acute myeloid leukemia

Engrailed-1 protein promotes pancreatic cancer progression and metastasis

NAEC develops updated guidelines to improve quality of care for people with severe epilepsy

Unveiling HIV's "latch": New study reveals key to blocking infection

CRISPR-Cas9 gene-editing tool repairs defective T cells to treat rare hereditary disease

Breakthrough gene-editing therapy transforms lives of patients with a hereditary disorder

New molecule is one step closer to becoming a treatment for Phelan-McDermid syndrome

Breakthrough recombinase technology ushers in precise, adaptable gene editing

Specific epigenetic pathway found to be involved in the development of melanoma drug resistance

X-chromosome inactivation and its role in autoimmune susceptibility in females

Identifying essential genetic regions for gestational diabetes with deep learning and cfDNA sequencing

Is there an association between vitamin D, immunocompetence, and aging?

The anti-cancer potential of sRNAs isolated from different mushroom species

Cerebellum plays key role in exercise-induced anxiety relief

Researchers detect genetic traces of hepatitis E viruses in wastewater

Combination drug treatment could be effective against malignant peripheral nerve sheath tumors

Eating up to three daily kimchi servings could reduce obesity risk in men

Study finds links between prenatal substance exposure and childhood mental health

Cadaveric pituitary-derived growth hormone delivery influences iatrogenic Alzheimer’s Disease

Vitamin D deficiency linked to increased dementia risk, supplements may help

eBook: Using iPSCs models for human disease research and drug discovery eBook

Lab Matters host Harriet Gould on building a more connected lab community

The Critical Role of Sample Storage in Drug Discovery and Development

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

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