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Study shows children with ALL can safely receive intravenous infusions of chemotherapy

Children with acute lymphoblastic leukemia (ALL), the most common form of pediatric cancer, can safely receive intravenous infusions of a reformulated mainstay of chemotherapy that has been delivered via painful intramuscular injection for more than 40 years, research suggests.

11 Dec 2013

Antibody-toxin compound shows compelling antitumor activity in non-Hodgkin lymphomas patients

A toxin linked to a targeted monoclonal antibody has shown "compelling" antitumor activity in patients with non-Hodgkin lymphomas who were no longer responding to treatment, according to a report from Dana-Farber Cancer Institute.

11 Dec 2013

Study links vitamin B12 deficiency to acid-suppressing medications

Long-term use of commonly prescribed heartburn and ulcer medications is linked to a higher risk of vitamin B12 deficiency, according to a new study published online in the Journal of the American Medical Association.

10 Dec 2013

Childhood trauma linked to poor social functioning in adult psychosis

Adults with first-episode psychosis who report childhood trauma tend to have poorer social functioning than those without such a history, a prospective study has shown.

10 Dec 2013

Restricting antibiotics use unlikely to stop spread of drug resistance in typhoid fever

Restricting the use of antibiotics is unlikely to stop the spread of drug resistance in typhoid fever, according to a study funded by the Wellcome Trust and published in the journal eLife.

10 Dec 2013

Concussive brain injuries can lead to depressive behaviors later in life

A head injury can lead immune-system brain cells to go on "high alert" and overreact to later immune challenges by becoming excessively inflammatory - a condition linked with depressive complications, a new animal study suggests.

10 Dec 2013

Athletes playing at higher altitudes suffer fewer concussions

A new study shows that high school athletes playing at higher altitudes suffer fewer concussions than those closer to sea-level, a phenomenon attributed to physiological changes in the brain causing it to fit more tightly in the skull.

9 Dec 2013

Research explores epigenetic effects that contribute to psychiatric disorders in offspring

Advanced paternal age has been associated with greater risk for psychiatric disorders, such as schizophrenia and autism. With an increase in paternal age, there is a greater frequency of certain types of mutations that contribute to these disorders in offspring.

9 Dec 2013

Insomnia linked to increased GERD risk

Insomnia is associated with an increased risk for gastroesophageal reflux disease, findings from a cross-sectional study show.

9 Dec 2013

Signs of inflammation in man’s prostate biopsy may indicate reduced risk

Signs of inflammation in a man’s prostate biopsy may indicate he has a reduced risk of subsequently being diagnosed with prostate cancer in a future biopsy. That’s the conclusion of a new study published early online in CANCER, a peer-reviewed journal of the American Cancer Society.

9 Dec 2013

Findings support health impact assessments of fine particles in Europe

Prolonged exposure to tiny particles of soot or dust found in traffic fumes and industrial emissions may be more deadly below current European Union air quality limits than previously thought, according to new research examining two decades of data from over 360 000 residents of large cities in 13 European countries.

9 Dec 2013

Malaria cases in the U.S. rising due to international travel, inadequate use of prevention methods

The number of malaria cases in the United States is rising, a trend that can be linked to the increasing amount of international travel and inadequate use of prevention methods.

9 Dec 2013

New form of gene therapy shows promising outcomes for "bubble boy" disease

Researchers reported promising outcomes data for the first group of boys with X-linked severe combined immunodeficiency syndrome (SCID-X1), a fatal genetic immunodeficiency also known as "bubble boy" disease, who were treated as part of an international clinical study of a new form of gene therapy. The mechanism used to deliver the gene therapy is designed to prevent the serious complication of leukemia that arose a decade ago in a similar trial in Europe, when one-quarter of boys treated developed the blood cancer.

9 Dec 2013

Genetically engineered cell therapies demonstrate early efficacy, safety in patients with blood disorders

A series of advancements in genetically engineered cell therapies demonstrate early efficacy and safety in patients with blood disorders for whom standard treatments have been unsuccessful, according to data showcased today during the 55th American Society of Hematology (ASH) Annual Meeting and Exposition in New Orleans.

9 Dec 2013

Research findings suggest possible novel strategies to prevent SUDEP

Patients with epilepsy and, in particular, those with severe syndromic forms of the disorder, harbor a risk of sudden unexplained death in epilepsy, or SUDEP. Cardiac arrhythmias are a proposed cause. In a test of this theory, researchers have demonstrated that mice harboring a human SCN1A gene mutation that results in Dravet Syndrome, a severe and intractable genetic epilepsy, have electrical disturbances in the heart that culminate in ventricular fibrillation and sudden cardiac death.

9 Dec 2013

Taking probiotics during pregnancy has no effect on asthma rate amoung infants

Taking probiotics has health benefits but preventing childhood asthma isn't one of them, shows newly published research led by medical scientists at the University of Alberta.

9 Dec 2013

Study helps explain why survival gap persists for African-Americans with head and neck cancer

A team of scientists at Johns Hopkins and in Texas has identified a handful of genetic mutations in black Americans, in addition to some chemical alterations affecting gene activity, which may help explain why the death rate among African-Americans from the most common form of head and neck cancer continues to hover some 18 percent higher above the death rate of whites with the same cancer.

9 Dec 2013

Increased levels of protein HSET linked with worse breast cancer outcomes in African-Americans

Among African-American women with breast cancer, increased levels of the protein HSET were associated with worse breast cancer outcomes, according to results presented here at the Sixth AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved, held Dec. 6-9.

9 Dec 2013

Scientists target protein-detection approach to systematically measure human repertoire of proteins

An international team of scientists led by Fred Hutchinson Cancer Research Center cancer proteomics expert Amanda Paulovich, M.D., has demonstrated the feasibility of large-scale, standardized protein measurements, which are necessary for validation of disease biomarkers and drug targets.

9 Dec 2013

Skin is capable of communicating with liver, say researchers

Researchers from the University of Southern Denmark have discovered that the skin is capable of communicating with the liver. The discovery has surprised the scientists, and they say that it may help our understanding of how skin diseases can affect the rest of the body.

9 Dec 2013

X linked News and Research

Study shows children with ALL can safely receive intravenous infusions of chemotherapy

Antibody-toxin compound shows compelling antitumor activity in non-Hodgkin lymphomas patients

Study links vitamin B12 deficiency to acid-suppressing medications

Childhood trauma linked to poor social functioning in adult psychosis

Restricting antibiotics use unlikely to stop spread of drug resistance in typhoid fever

Concussive brain injuries can lead to depressive behaviors later in life

Athletes playing at higher altitudes suffer fewer concussions

Research explores epigenetic effects that contribute to psychiatric disorders in offspring

Insomnia linked to increased GERD risk

Signs of inflammation in man’s prostate biopsy may indicate reduced risk

Findings support health impact assessments of fine particles in Europe

Malaria cases in the U.S. rising due to international travel, inadequate use of prevention methods

New form of gene therapy shows promising outcomes for "bubble boy" disease

Genetically engineered cell therapies demonstrate early efficacy, safety in patients with blood disorders

Research findings suggest possible novel strategies to prevent SUDEP

Taking probiotics during pregnancy has no effect on asthma rate amoung infants

Study helps explain why survival gap persists for African-Americans with head and neck cancer

Increased levels of protein HSET linked with worse breast cancer outcomes in African-Americans

Scientists target protein-detection approach to systematically measure human repertoire of proteins

Skin is capable of communicating with liver, say researchers

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