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Study: Genes may play a far more complex role in oocyte maturation than previously assumed

Over the last six years a group of Estonian geneticists led by Associate Professor Agne Velthut-Meikas and a PhD student Ilmatar Rooda from TalTech Department of Chemistry and Biotechnology have studied genes previously associated primarily with female hormone synthesis and ovarian follicle development.

7 May 2020

SARS-CoV-2 in wastewater and rivers

A new study published on the preprint server medRxiv in May 2020 shows that while the virus causing COVID-19 may be present in wastewater and rivers, the biological agent is typically devoid of vitality and unable to cause active infection. This should provide some relief to public health authorities in their quest to contain the virus.

6 May 2020

Study discovers inhibition of SARS-CoV-2 entry priming protein by approved drug

The COVID-19 pandemic caused by the severe acute respiratory syndrome -coronavirus 2 (SARS-CoV-2) has spread to most of the world, causing millions of cases and hundreds of thousands of deaths. A new study published on the preprint server bioRxiv* shows that a protease inhibitor drug already approved by the Food and Drug Administration (FDA) could inhibit viral entry.

6 May 2020

Low CD8 and NK cell counts in the lung linked to high SARS-CoV-2 ACE2 receptor levels

A new study published on the preprint server bioRxiv in April 2020 reports that low levels of specific immune cells, namely, CD8 T cells and NK cells, are linked to higher expression of the ACE2 molecule, which acts as a receptor for the CoV.

6 May 2020

Spillover of more bat coronaviruses likely due to destruction of wildlife habitats

A new study available on the preprint server bioRxiv used phylogenetic analysis to demonstrate how certain groups of bats harbor multiple coronavirus lineages that are not readily transmitted across different bat taxa. However, the researchers caution that another novel human coronavirus outbreak originating from bats is imminent due to the destruction of wildlife habitats.

6 May 2020

Is ACEI, ARB use linked to testing positive for COVID-19?

A new study published in the prestigious journal JAMA Cardiology in May 2020 reports that there is no association between the use of ACEIs/ARBs and testing positive for COVID-19. This supports current medical advice to continue using these drugs as indicated irrespective of the ongoing pandemic but indicates the need for more research to rule out any additional risk of severe illness due to these agents.

6 May 2020

SARS-CoV-2 genome shows mutation hotspots and type-specific distribution

Now, a new study published on the preprint server bioRxiv reports on a large scale analysis of SARS-CoV-2 genomes and reveals a clonal geo-distribution and rich genetic variations.

5 May 2020

COVID-19 infection risk and outcomes explained by the cell receptor genetic variability

Genetic variants in the angiotensin‐converting enzyme 2 (ACE2) receptor, utilized by the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) for cell entry, are predicted to either encourage or inhibit interaction with viral proteins and subsequently contribute to genetic risk in coronavirus disease (COVID-19). This is the key finding of a new study available on the preprint server bioRxiv*.

5 May 2020

Allergic reactions can occur without being triggered by an allergen, finds study

Allergic reactions can occur without being triggered by an allergen such as grass or birch pollen - it is enough for the patient to be back in the same place in which he or she was previously exposed to the allergen, as researchers at the University of Tübingen have found.

5 May 2020

Study finds intake of BioCell Collagen decreases common signs of photoaging

Building on an extensive body of research on the efficacy of BioCell Collagen®, a new published laboratory study finds that daily supplementation with the branded matrix reduced common signs of UVB-induced photoaging compared to the group that did not receive the supplement.

5 May 2020

Russian scientists create humanized mice to test drugs and vaccines for COVID-19

Following the recent Coronavirus outbreak, almost three million people have been infected worldwide, whereas the death toll has already passed the 200,000 mark, according to official reports.

5 May 2020

Scientists are exploring to find the 'Achilles heel' of coronavirus

Coronavirus, or more exactly SARS-CoV-2, has the world in its grip. How does the virus manage to bind to cells in the human body? How does it gain entry to the cell? How does it hijack the cell's machinery to make it help to replicate the viral genome?

5 May 2020

Loss of smell may be related to neuroinvasive propensity of SARS-CoV-2

The novel coronavirus has rapidly infected millions over the world in over 187 countries and territories, causing hundreds of thousands of deaths. One of the often-neglected and under-reported symptoms of the virus is the loss of the sense of smell or anosmia. Now, a new study out of Germany published on the preprint server medRxiv in April 2020 provides a quantified estimate of the magnitude of anosmia as a symptom of the coronavirus.

4 May 2020

Wyss Institute and Cytosurge collaborate to improve CRISPR multiplexing

Today, the Wyss Institute for Biologically Inspired Engineering at Harvard University and Cytosurge AG, a company manufacturing unique high-precision nanotechnology instruments, announced that they will collaboratively investigate CRISPR-based approaches to more effectively introduce multiple edits into the genome of single cells, while minimizing CRISPR-related toxicity.

4 May 2020

Study defines new starting points for therapy and vaccine research on coronavirus

The SARS coronavirus 2 (SARS-CoV-2) infects lung cells and is responsible for the COVID-19 pandemic. The viral spike protein mediates entry of the virus into host cells and harbors an unusual activation sequence.

4 May 2020

Scientists develop CRISPR-based test for SARS-CoV-2

Now, a team of scientists at the University of California Santa Barbara has developed a low-cost, rapid, and high-tech test that can detect SARS-CoV-2 effectively. They have developed a CRISPR-based test that is sensitive and effective as traditional tests.

4 May 2020

Researchers discover hidden symmetry in chemical kinetic equations

Rice University researchers have discovered a hidden symmetry in the chemical kinetic equations scientists have long used to model and study many of the chemical processes essential for life.

4 May 2020

SARS-CoV-2 receptor ‘mimic' could prevent COVID-19

Researchers from Italy have developed an exciting new peptide drug that could potentially prevent the coronavirus from infecting people’s cells. The paper, published on the preprint server bioRxiv* in April 2020, describes a small molecule that can bind to and block the attachment site on the virus spike protein, preventing its entry into the host cell.

4 May 2020

Real-time monitoring of biochemical processes on DNA using infrared spectroscopy

DNA damage in general and DNA strand breaks in particular occur every day in all cells of the human body.

3 May 2020

Study reports cryo-EM structure of Remdesivir-bound RNA replicase complex from SARS-CoV-2

A team of Chinese scientists have reported the high-resolution cryo-EM structure of Remdesivir-bound RNA replicase complex from SARS-CoV-2, the infective virus of COVID-19.

3 May 2020

Enzyme News and Research

Study: Genes may play a far more complex role in oocyte maturation than previously assumed

SARS-CoV-2 in wastewater and rivers

Study discovers inhibition of SARS-CoV-2 entry priming protein by approved drug

Low CD8 and NK cell counts in the lung linked to high SARS-CoV-2 ACE2 receptor levels

Spillover of more bat coronaviruses likely due to destruction of wildlife habitats

Is ACEI, ARB use linked to testing positive for COVID-19?

SARS-CoV-2 genome shows mutation hotspots and type-specific distribution

COVID-19 infection risk and outcomes explained by the cell receptor genetic variability

Allergic reactions can occur without being triggered by an allergen, finds study

Study finds intake of BioCell Collagen decreases common signs of photoaging

Russian scientists create humanized mice to test drugs and vaccines for COVID-19

Scientists are exploring to find the 'Achilles heel' of coronavirus

Loss of smell may be related to neuroinvasive propensity of SARS-CoV-2

Wyss Institute and Cytosurge collaborate to improve CRISPR multiplexing

Study defines new starting points for therapy and vaccine research on coronavirus

Scientists develop CRISPR-based test for SARS-CoV-2

Researchers discover hidden symmetry in chemical kinetic equations

SARS-CoV-2 receptor ‘mimic' could prevent COVID-19

Real-time monitoring of biochemical processes on DNA using infrared spectroscopy

Study reports cryo-EM structure of Remdesivir-bound RNA replicase complex from SARS-CoV-2

Biochemical Assays for Efficient Hit Prioritization After Screening eBook

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