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Xist lncRNA identified as key trigger in female-biased autoimmune diseases

Researchers uncover that the Xist ribonucleoprotein complex, unique to females, is a key driver of sex-biased autoimmunity, offering new insights into autoimmune disorders' higher prevalence in women.

4 Feb 2024

Small-molecule A485 mobilizes white blood cells on demand

New study reveals a small molecule that can selectively mobilize white blood cells, offering potential treatments for diseases with abnormal leukocyte counts.

3 Feb 2024

Gut health linked to Alzheimer's progression, study suggests diet as potential therapy

Study reviews the intricate relationship between diet, gut microbiome diversity, and Alzheimer’s disease progression, suggesting gut health could play a key role in managing the disease.

3 Feb 2024

CAR T cells target senescent cells, improve healthspan in mice

Chimeric antigen receptor (CAR) T cells have transformed the treatment of blood cancers in recent years. And there have been positive signs the "living drugs" can be harnessed against other diseases, like autoimmune disorders.

2 Feb 2024

CRISPR-Cas9 gene-editing tool repairs defective T cells to treat rare hereditary disease

Some hereditary genetic defects cause an exaggerated immune response that can be fatal. Using the CRISPR-Cas9 gene-editing tool, such defects can be corrected, thus normalizing the immune response, as researchers led by Klaus Rajewsky from the Max Delbrück Center now report in "Science Immunology."

2 Feb 2024

New therapy helps dementia patients and family carers achieve personal goals

Research led by Claudia Cooper, Professor of Psychological Medicine at Queen Mary University of London, shows that a new therapy, NIDUS-Family, helps people with dementia and their family carers attain their personal goals.

2 Feb 2024

Breakthrough gene-editing therapy transforms lives of patients with a hereditary disorder

A group of patients with a hereditary disorder have had their lives transformed by a single treatment of a breakthrough gene-editing therapy, according to the lead researcher.

2 Feb 2024

Breakthrough recombinase technology ushers in precise, adaptable gene editing

A team of researchers at the Carl Gustav Carus Faculty of Medicine, TUD Dresden University of Technology, led by Prof. Frank Buchholz, has achieved a major breakthrough in genome editing technology.

1 Feb 2024

Phase II clinical trial evaluates the safety and efficacy of a Muse cell-based product in patients with ALS

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by progressive loss of motor functions, which eventually leads to death within 5 years of its onset.

1 Feb 2024

Next-gen BTK degrader could help overcome treatment resistance in chronic lymphocytic leukemia

New research from Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine and collaborating organizations has identified a next-generation BTK degrader that could help overcome treatment resistance in chronic lymphocytic leukemia (CLL) and related blood cancers.

1 Feb 2024

Specific epigenetic pathway found to be involved in the development of melanoma drug resistance

One of the major challenges in cancer research and clinical care is understanding the molecular basis for therapeutic resistance as a major cause of long term treatment failures.

1 Feb 2024

New approach offers hope for regaining lost memories in Alzheimer's

While newly approved drugs for Alzheimer's show some promise for slowing the memory-robbing disease, the current treatments fall far short of being effective at regaining memory.

1 Feb 2024

Study: Most stroke survivors can safely take two types of common antidepressants

Most stroke survivors were able to safely take two types of common antidepressants, according to a preliminary study to be presented at the American Stroke Association's International Stroke Conference 2024.

1 Feb 2024

Nerve stimulation plus physical rehabilitation may boost recovery of arm and hand function

Combining brain stimulation with intense physical rehabilitation helped stroke survivors recover movement in their arms and hands and maintain these improvements for one year, according to a study to be presented at the American Stroke Association's International Stroke Conference 2024.

1 Feb 2024

New sequencing tool speeds up SARS-CoV-2 outbreak response and informs treatment

Announcing a new article publication for Zoonoses journal. In the context of two Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) outbreaks involving local transmission and an international flight, the authors of this article used meta-transcriptome and multi-amplicon sequencing to successfully acquire the complete viral genome sequences from clinical samples with varying viral loads.

1 Feb 2024

CT scans may be better first step for evaluating chest pain

Previous studies have found less than 40% of patients with stable chest pain undergoing invasive coronary angiography are found to have obstructive coronary artery disease.

1 Feb 2024

Virtual relaxation therapy reduces distress in end-of-life care

A new study published in Frontiers in Virtual Reality explored the effectiveness of a psychological strategy called Flourishing-Life-Of-Wish Virtual Reality Therapy (FLOW-VRT)® in helping people cope with their symptoms and achieve relaxation at the end of life.

1 Feb 2024

CRISPR revolutionized: New method edits genes directly in the body

Most approved gene therapies today, including those involving CRISPR-Cas9, work their magic on cells removed from the body, after which the edited cells are returned to the patient.

1 Feb 2024

Early whole blood transfusion boosts survival in trauma patients

Significant bleeding due to traumatic injury is the number one cause of preventable deaths in the U.S., with the majority of deaths occurring within six hours.

31 Jan 2024

Study paves the way for improving personalized treatment of patients with glioblastoma

A study led by the ITACA Institute of the Universitat Politècnica de València, with the participation of the Institut Català d'Oncologia (ICO), the Institut Investigació Germans Trias I Pujol (IGTP) and the Hospital Clinic de Barcelona, opens up a novel approach for improving personalized treatments for patients with glioblastoma, one of the most aggressive types of cancer in existence today.

31 Jan 2024

Therapy News and Research

Xist lncRNA identified as key trigger in female-biased autoimmune diseases

Small-molecule A485 mobilizes white blood cells on demand

Gut health linked to Alzheimer's progression, study suggests diet as potential therapy

CAR T cells target senescent cells, improve healthspan in mice

CRISPR-Cas9 gene-editing tool repairs defective T cells to treat rare hereditary disease

New therapy helps dementia patients and family carers achieve personal goals

Breakthrough gene-editing therapy transforms lives of patients with a hereditary disorder

Breakthrough recombinase technology ushers in precise, adaptable gene editing

Phase II clinical trial evaluates the safety and efficacy of a Muse cell-based product in patients with ALS

Next-gen BTK degrader could help overcome treatment resistance in chronic lymphocytic leukemia

Specific epigenetic pathway found to be involved in the development of melanoma drug resistance

New approach offers hope for regaining lost memories in Alzheimer's

Study: Most stroke survivors can safely take two types of common antidepressants

Nerve stimulation plus physical rehabilitation may boost recovery of arm and hand function

New sequencing tool speeds up SARS-CoV-2 outbreak response and informs treatment

CT scans may be better first step for evaluating chest pain

Virtual relaxation therapy reduces distress in end-of-life care

CRISPR revolutionized: New method edits genes directly in the body

Early whole blood transfusion boosts survival in trauma patients

Study paves the way for improving personalized treatment of patients with glioblastoma

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Advancing Intracellular Delivery with LumiPore®

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