immunity News and Research

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Neutralization antibodies affected by only a few mutations to the SARS-CoV-2 receptor-binding domain

In a recent bioRxiv* preprint paper, US researchers mapped in detail how mutations to the receptor-binding domain (RBD) of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) affected antibody binding in convalescent human serum – and revealed that it is influenced by mutations at only a handful of dominant epitopes.

6 Jan 2021

Modified Vaccinia Ankara model vaccine prevents COVID-19 in transgenic mice study

A new study shows the effectiveness of a novel recombinant vaccinia virus that expresses modified SARS-CoV-2 spike antigen, in preventing the replication of the virus in the respiratory tract of transgenic mice, and to prevent lethal disease.

6 Jan 2021

New mathematical model proposes optimal treatment strategies for COVID-19

Getting control of COVID-19 will take more than widespread vaccination; it will also require a better understanding of why the disease causes no apparent symptoms in some people but leads to rapid multi-organ failure and death in others, as well as better insight into what treatments work best and for which patients.

5 Jan 2021

COVID-19 vaccine hesitancy in UK varies significantly between population subgroups

Researchers investigating attitudes towards vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) among the UK population have found that, overall, most people were willing to accept a vaccine.

5 Jan 2021

COVID-19 vaccination in UK may not lead to relaxation of control measures

Researchers have warned that early relaxation of coronavirus disease 2019 (COVID-19) control measures in the UK could lead to pronounced waves of further infection with the causative agent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

5 Jan 2021

Researchers reveal distinct molecular signature in tumor tissues of Black breast cancer patients

A Roswell Park Comprehensive Cancer Center team led by Christine Ambrosone, PhD, and Song Yao, PhD, has revealed a distinct molecular signature in the tumor tissues of Black patients with breast cancer.

5 Jan 2021

Researchers develop immunity monitoring to determine the efficacy of COVID-19 vaccine

As the COVID-19 vaccine becomes available to the public, immunity monitoring will play an important role in determining whether the vaccine is effective for an individual, and for how long.

5 Jan 2021

Researchers discover protein crucial to T cell metabolism and anti-tumor immune response

Researchers at The University of Texas MD Anderson Cancer Center have discovered that a protein called NF-kappa B-inducing kinase (NIK) is essential for the shift in metabolic activity that occurs with T cell activation, making it a critical factor in regulating the anti-tumor immune response.

4 Jan 2021

Research offers clues on why pregnancy may raise risk of organ transplant rejection

A research study at the University of Chicago has found that in pregnancy, while the T cell response to a fetus becomes tolerant to allow for successful pregnancy, the part of the immune system that produces antibodies (known as the humoral response) becomes sensitized, creating memory B cells that can later contribute to the rejection of a transplanted organ.

4 Jan 2021

Study shows mRNA-1273 vaccine can prevent symptomatic COVID-19 infection

A peer-reviewed paper published in The New England Journal of Medicine provides data from the much-anticipated COVE study, which evaluated mRNA-1273, a vaccine candidate against COVID-19 manufactured by Moderna, Inc.

3 Jan 2021

Sustained immune dysregulation due to COVID-19 in non-hospitalized patients

COVID-19, which has killed 1.7 million people worldwide, does not follow a uniform path.

29 Dec 2020

New, rapid antibody test gives detailed information on how the immune system reacts to Covid-19

A new type of antibody test is being developed by researchers at Linnaeus University and the bioanalysis company Attana. Compared to the binary antibody tests used today, this rapid test can give more detailed information on how our immune systems react to Covid-19 and other types of viruses and bacteria.

29 Dec 2020

Gut cells alert the body to danger during parasite invasion

To effectively combat an infection, the body first has to sense it's been invaded, then the affected tissue must send out signals to corral resources to fight the intruder.

28 Dec 2020

Phase 3 trial of Novavax COVID-19 vaccine candidate begins enrolling volunteers

The Phase 3 trial of another investigational coronavirus disease 2019 (COVID-19) vaccine has begun enrolling adult volunteers.

28 Dec 2020

Severity of COVID-19 correlates with the ratio of antibodies targeting crucial viral protein

COVID-19 antibodies preferentially target a different part of the virus in mild cases of COVID-19 than they do in severe cases, and wane significantly within several months of infection, according to a new study by researchers at Stanford Medicine.

24 Dec 2020

Researchers find mechanism underlying plasticity in adult brains

Developing brains constantly sprout new neuronal connections called synapses as they learn and remember. Important connections — the ones that are repeatedly introduced, such as how to avoid danger — are nurtured and reinforced, while connections deemed unnecessary are pruned away.

24 Dec 2020

Higher BMI linked to increased risk of SARS-CoV-2 infection

Researchers at the University of Miami Miller School of Medicine, USA, revealed that the spike-specific immunoglobulin G antibodies in obese people are negatively associated with body mass index (BMI) and serum levels of proinflammatory and metabolic markers of pulmonary inflammation.

24 Dec 2020

immunity News and Research

Neutralization antibodies affected by only a few mutations to the SARS-CoV-2 receptor-binding domain

Modified Vaccinia Ankara model vaccine prevents COVID-19 in transgenic mice study

New mathematical model proposes optimal treatment strategies for COVID-19

COVID-19 vaccine hesitancy in UK varies significantly between population subgroups

COVID-19 vaccination in UK may not lead to relaxation of control measures

Researchers reveal distinct molecular signature in tumor tissues of Black breast cancer patients

Researchers develop immunity monitoring to determine the efficacy of COVID-19 vaccine

Researchers discover protein crucial to T cell metabolism and anti-tumor immune response

Research offers clues on why pregnancy may raise risk of organ transplant rejection

Study shows mRNA-1273 vaccine can prevent symptomatic COVID-19 infection

Sustained immune dysregulation due to COVID-19 in non-hospitalized patients

New, rapid antibody test gives detailed information on how the immune system reacts to Covid-19

Gut cells alert the body to danger during parasite invasion

Phase 3 trial of Novavax COVID-19 vaccine candidate begins enrolling volunteers

Severity of COVID-19 correlates with the ratio of antibodies targeting crucial viral protein

Researchers find mechanism underlying plasticity in adult brains

Higher BMI linked to increased risk of SARS-CoV-2 infection

Kobe University and Sysmex conduct joint research on ELISPOT method for identifying COVID-19

Thymus gland works to prevent miscarriage, diabetes in pregnant women

At risk of extinction, black-footed ferrets get experimental COVID vaccine

Exploring Strategies for Targeting Kinases in Innate Immunity eBook

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

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