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Liver trigger holds the key to boosting gene therapy success

Indiana University School of Medicine researchers have uncovered vital insights regarding a liver trigger that blocks an undesired immune response from gene therapy, surprisingly resulting in the activation of specific immune cells, despite the liver's typical role in suppressing immune responses.

7 Dec 2023

Immunoregulatory nanomedicines for the prevention and treatment of respiratory diseases

Study explores immunoregulatory nanomedicines for respiratory infections, highlighting their potential in enhancing treatment outcomes and vaccine efficacy.

7 Dec 2023

Novel stem cell treatment could revolutionize liver disease management

Mortality related to end stage liver disease is ranked as the 12th most common cause of death in the U.S. Liver transplantation remains the only treatment for end stage liver disease, but there is a critical shortage of organ donors, necessitating a dire need for new forms of treatment.

7 Dec 2023

COST's Network of Actions against COVID-19

Throughout history, infectious diseases have been a constant presence, and this is still the case today, with frequent outbreaks.

7 Dec 2023

Novel mechanism leads to motor neuron degeneration in spinal muscular atrophy

The lab of Yongchao C. Ma, PhD, at Stanley Manne Children's Research Institute at Ann & Robert H. Lurie Children's Hospital of Chicago uncovered a novel mechanism that leads to motor neuron degeneration in spinal muscular atrophy (SMA).

7 Dec 2023

New early phase study evaluates “on-demand” HIV prevention method for women

A fast-dissolving vaginal insert that women would use at or around the time of sex as an "on-demand" HIV prevention method is being evaluated in a new early phase study being conducted by MATRIX, a United States Agency for International Development (USAID)-funded project focused on the early research and development of innovative HIV prevention products for women.

7 Dec 2023

IDEA trial: Skipping radiotherapy safe for younger postmenopausal patients with early-stage breast cancer

Almost all postmenopausal patients aged 50-69 years with stage I hormone receptor (HR)-positive breast cancer and low scores on a common genetic test who opted out of adjuvant radiotherapy were disease free five years after surgery, according to results from the IDEA clinical trial presented at the San Antonio Breast Cancer Symposium, held December 5-9, 2023.

7 Dec 2023

EU funds the international "BEHIND-MS" consortium to tackle multiple sclerosis

Multiple sclerosis (MS), an inflammatory disease of the central nervous system, affects more than 1 million people in Europe and an estimated 2.8 million worldwide.

7 Dec 2023

A step forward in vaccine technology: Exploring the effects of N1-methylpseudouridine in mRNA translation

Researchers explored how the incorporation of N1-methylpseudouridine (1-methylΨ) into mRNAs affects ribosomal frameshifting and the overall fidelity of mRNA translation.

7 Dec 2023

Associations between low-inflammatory diets and diabetes risk

Associations between a low-inflammatory diet and type 2 diabetes (T2D) risk.

7 Dec 2023

The association between viral infections and glioma risk

The causal relationship between viral infection and glioma.

7 Dec 2023

Design modifications offer promise for safer and more effective mRNA therapeutics

Researchers have discovered that misreading of therapeutic mRNAs by the cell's decoding machinery can cause an unintended immune response in the body.

6 Dec 2023

HDAC inhibitors may offer new strategy for reversing fibrotic wall around pancreatic tumors

Pancreatic cancer is one of the deadliest cancers - only about one in eight patients survives five years after diagnosis.

6 Dec 2023

Music could hold the key to developing effective mental health interventions

How human beings respond to music and the biological underpinnings of this response.

6 Dec 2023

Exploring the genetic links: Alcohol, smoking, coffee intake, and arthritis risk

The genetic relationship between alcohol consumption, smoking, coffee intake, and the risk of arthritis.

6 Dec 2023

Study reveals subclinical cardiac changes in Hispanic women with history of hypertensive pregnancy disorders

The long-term cardiac effects of de novo hypertensive disorders of pregnancy.

6 Dec 2023

Pioneering Visions: Michael Stryker's Contributions to Understanding the Visual Cortex

In this interview conducted at the Society for Neuroscience's Neuroscience 2023, we explore the fascinating world of neuroscience with Professor Michael Stryker, a leading expert with over four decades of groundbreaking research.

6 Dec 2023

New genetic links to coronary artery calcification uncovered, offering treatment insights

A study in Nature Cardiovascular Research identifies two new genetic loci associated with coronary artery calcification (CAC), a key indicator of atherosclerosis and coronary artery disease.

5 Dec 2023

Mediterranean diet linked to improved sperm quality

A study in the journal Nutrients finds that adherence to the Mediterranean diet positively correlates with improved sperm parameters in men. This observational cross-sectional study, involving 300 non-obese males, revealed that higher adherence to the diet is associated with better sperm motility, morphology, viability, and count, suggesting that diet can be a crucial factor in male fertility.

5 Dec 2023

Study identifies genetic indicators to predict the decline of cognitive abilities

For some people, extreme stressors like psychiatric disorders or childhood neglect and abuse can lead to a range of health problems later in life, including depression, anxiety and cardiovascular disease.

5 Dec 2023

Genetic News and Research

Liver trigger holds the key to boosting gene therapy success

Immunoregulatory nanomedicines for the prevention and treatment of respiratory diseases

Novel stem cell treatment could revolutionize liver disease management

COST's Network of Actions against COVID-19

Novel mechanism leads to motor neuron degeneration in spinal muscular atrophy

New early phase study evaluates “on-demand” HIV prevention method for women

IDEA trial: Skipping radiotherapy safe for younger postmenopausal patients with early-stage breast cancer

EU funds the international "BEHIND-MS" consortium to tackle multiple sclerosis

A step forward in vaccine technology: Exploring the effects of N1-methylpseudouridine in mRNA translation

Associations between low-inflammatory diets and diabetes risk

The association between viral infections and glioma risk

Design modifications offer promise for safer and more effective mRNA therapeutics

HDAC inhibitors may offer new strategy for reversing fibrotic wall around pancreatic tumors

Music could hold the key to developing effective mental health interventions

Exploring the genetic links: Alcohol, smoking, coffee intake, and arthritis risk

Study reveals subclinical cardiac changes in Hispanic women with history of hypertensive pregnancy disorders

Pioneering Visions: Michael Stryker's Contributions to Understanding the Visual Cortex

New genetic links to coronary artery calcification uncovered, offering treatment insights

Mediterranean diet linked to improved sperm quality

Study identifies genetic indicators to predict the decline of cognitive abilities

Sequencing & Genomics: Elevating Science and Healthcare eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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