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High-titer convalescent plasma reduced COVID-19 symptom severity in green monkeys

As scientists scramble to find effective vaccines and antivirals for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a recent study published on the preprint server bioRxiv in October 2020 reports that the use of convalescent plasma to treat COVID-19 disease early in the course of the illness may be among the best available strategies at present.

16 Oct 2020

New self-expanding bioprosthetic valve used in TAVR fails to demonstrate non-inferiority

In a randomized clinical trial, SCOPE II, a new self-expanding bioprosthetic valve used in transcatheter aortic valve replacement (TAVR) failed to demonstrate non-inferiority compared to an existing self-expanding valve.

16 Oct 2020

Tech Spotlight honors ISSCR's stem cell based clinical trials guide

The ISSCR's Stem Cell-Based Clinical Trials: Practical Advice for Physicians and Ethics/Institutional Review Committees was honored today by Tech Spotlight at Harvard Kennedy School's Belfer Center.

16 Oct 2020

Glutathione precursor improves multiple deficits associated with premature aging

Premature aging in people with HIV is now recognized as a new, significant public health challenge. Accumulating evidence shows that people with HIV who are between 45 to 60 years old develop characteristics typically observed in people without HIV that are more than 70 years of age.

15 Oct 2020

Electronic cigarettes better than nicotine replacement therapy to help people quit smoking

Electronic cigarettes could increase the number of people who stop smoking compared to nicotine replacement therapy – such as chewing gum and patches – according to research involving the University of East Anglia.

15 Oct 2020

FDA approves Regeneron antibody drug as first treatment for Ebola virus

Today, the U.S. Food and Drug Administration approved Inmazeb (atoltivimab, maftivimab, and odesivimab-ebgn), a mixture of three monoclonal antibodies, as the first FDA-approved treatment for Zaire ebolavirus (Ebola virus) infection in adult and pediatric patients.

14 Oct 2020

Scientists engineer tissue grafts for personalized joint replacement

The temporomandibular joint (TMJ), which forms the back portion of the lower jaw and connects your jaw to your skull, is an anatomically complex and highly loaded structure consisting of cartilage and bone.

14 Oct 2020

New clinical trial to test safety and efficacy of antibody cocktail against COVID-19

In a new clinical trial, UC Davis Health will test the effectiveness and safety of REGN-COV2, the monoclonal antibody cocktail, in preventing COVID-19 in adults living with infected patients.

14 Oct 2020

New clinical cleanroom manufacturing and training facility launches in Brisbane

The Hon Karen Andrews, Minister for Industry, Science and Technology is opening the Translational Research Institute's new state-of-the-art clinical cleanroom manufacturing and training facility, T3 Cleanrooms, and the inaugural MTPCareers Symposium on Wednesday 14 October 2020.

13 Oct 2020

CAR NKT cells offer a promising approach to combat hard-to-treat solid tumors

Natural killer T (NKT) cells, a type of immune cells known for their potent anti-cancer properties in murine tumor models, have been developed into a novel form of immunotherapy to treat patients with cancer.

13 Oct 2020

Researchers launch new clinical trial to investigate role of vitamin D against COVID-19

Researchers from Queen Mary University of London, funded by Barts Charity, have launched a new clinical trial to investigate whether taking vitamin D could protect people from COVID-19

13 Oct 2020

COVID-19 vaccine candidate shows potent immune response

A COVID-19 vaccine candidate that underwent extensive preclinical testing at the University of Alabama at Birmingham this spring and summer shows potent preclinical immune responses - including several that distinguish it from other COVID-19 vaccine approaches - according to a preprint deposited in the BioRxiv repository this week.

13 Oct 2020

Neoadjuvant trial of combination immunotherapy has favorable outcomes in bladder cancer patients

Neoadjuvant, or pre-surgical, combination treatment with the immune checkpoint inhibitors tremelimumab (anti-CTLA-4) and durvalumab (anti-PD-1) was well-tolerated and showed early signs of activity in certain patients with localized bladder cancer who do not have standard treatment options available, according to a Phase I clinical trial conducted by The University of Texas MD Anderson Cancer Center.

13 Oct 2020

Study shows unique cardioprotective properties of an old drug

A drug costing less than 2 euros per dose could reduce the long term consequences of a heart attack, benefitting millions of patients. Metoprolol, a member of the beta-blocker class of drugs that has been in use for more than 40 years, has been found to have unique cardioprotective properties.

9 Oct 2020

UroCAD assay is better than urine cytology in detecting bladder cancer

Analysis of DNA copy number variants (CNVs) in the cells exfoliated in urine showed better sensitivity and similar specificity in detecting urothelial carcinoma compared with urine cytology.

9 Oct 2020

Study offers new insights about myopia management

CooperVision is reporting the latest findings from its landmark MiSight® 1 day clinical study, providing new insights about myopia management and the proven efficacy of the specially designed contact lens.

9 Oct 2020

Novel radioimmunotherapy proven effective in reversing resistance to lymphoma therapy

A new radioimmunotherapy has proven effective in reversing resistance to the most commonly used lymphoma drug, rituximab, according to research published in the October issue of The Journal of Nuclear Medicine.

8 Oct 2020

NIH clinical trial to test a combination treatment regimen for COVID-19

A clinical trial to test the safety, tolerability and efficacy of a combination treatment regimen for coronavirus disease 2019 (COVID-19) consisting of the antiviral remdesivir plus a highly concentrated solution of antibodies that neutralize SARS-CoV-2, the virus that causes COVID-19, has begun.

8 Oct 2020

FDA awards six clinical trial research grants to enhance development of therapies for rare diseases

Today, the U.S. Food and Drug Administration announced that it has awarded six new clinical trial research grants to principal investigators from academia and industry totaling over $16 million over the next four years.

8 Oct 2020

Exome sequencing sheds light on genetic causes of nonimmune hydrops fetalis

A new study by University of California researchers shows the promise of high-throughput DNA-sequencing technologies to improve prenatal diagnosis and pregnancy outcomes for women who have experienced an abnormal prenatal ultrasound.

8 Oct 2020

Clinical Trial News and Research

High-titer convalescent plasma reduced COVID-19 symptom severity in green monkeys

New self-expanding bioprosthetic valve used in TAVR fails to demonstrate non-inferiority

Tech Spotlight honors ISSCR's stem cell based clinical trials guide

Glutathione precursor improves multiple deficits associated with premature aging

Electronic cigarettes better than nicotine replacement therapy to help people quit smoking

FDA approves Regeneron antibody drug as first treatment for Ebola virus

Scientists engineer tissue grafts for personalized joint replacement

New clinical trial to test safety and efficacy of antibody cocktail against COVID-19

New clinical cleanroom manufacturing and training facility launches in Brisbane

CAR NKT cells offer a promising approach to combat hard-to-treat solid tumors

Researchers launch new clinical trial to investigate role of vitamin D against COVID-19

COVID-19 vaccine candidate shows potent immune response

Neoadjuvant trial of combination immunotherapy has favorable outcomes in bladder cancer patients

Study shows unique cardioprotective properties of an old drug

UroCAD assay is better than urine cytology in detecting bladder cancer

Study offers new insights about myopia management

Novel radioimmunotherapy proven effective in reversing resistance to lymphoma therapy

NIH clinical trial to test a combination treatment regimen for COVID-19

FDA awards six clinical trial research grants to enhance development of therapies for rare diseases

Exome sequencing sheds light on genetic causes of nonimmune hydrops fetalis

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