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A survey on computational methods in discovering protein inhibitors of SARS-CoV-2

Researchers review diverse computational methods for drug/inhibitor design and enzymes as potential targets for inhibitors to treat coronaviruses diseases.

12 Oct 2021

A mucoadhesive polymer with anti-SARS-COV-2 activity in vitro and in vivo

The team has evaluated a low molecular weight chitosan derivative as a candidate preventing the viral entry into mammalian nasal epithelial cells to limit the spread of COVID-19.

12 Oct 2021

Taste loss as a COVID-19 symptom: a review

A new review reports that alterations in taste affected about a third of individuals with a COVID-19 diagnosis, with females being affected more than males.

12 Oct 2021

Vaccinated children induced significantly higher antibody titers than naturally SARS-CoV-2 infected children

A recent preprint discusses the antibody response to the nucleic acid vaccines against SARS-CoV-2 when administered to children aged 7-11 years.

12 Oct 2021

Nucleoside modifications suppress the potential of RNA to activate dendritic cells

A new paper shows that human TLR3, TLR7, and TLR8 receptors are activated with naturally occurring RNA, but this is eliminated once modified nucleosides such as m5C, m6A, m5U s2U, or pseudouridine are incorporated.

12 Oct 2021

A new bacterial two-hybrid assay to study SARS-CoV-2 interactome

Recently, scientists have developed a bacterial two-hybrid (B2H) system to study the PPIs of SARS-CoV-2 in a heterologous non-eukaryotic system. This study is available on the bioRxiv* preprint server. Put simply, the B2H system could be used to analyze the SARS-CoV-2 proteome.

11 Oct 2021

Analysis of SARS-CoV-2 Delta variant transmissibility across New England, USA

A recent study compares the transmissibility of the SARS-CoV-2 Alpha and Delta variants in six states across New England in the United States

11 Oct 2021

COVID-19 vaccination elicits broader antibody response to SARS-CoV-2 spike than infection

A recent study demonstrates that antibodies generated in response to mRNA-based COVID-19 vaccination target more epitopes across the spike protein.

11 Oct 2021

An investigation of SARS-CoV-2 infection in diabetic pregnancies

Researchers discuss the basic and clinical science of the potential inter-relationships between diabetes mellitus and COVID-19 in pregnancies.

11 Oct 2021

SARS-CoV-2 immune responses in nursing home residents after full vaccination with Pfizer-BioNTech COVID-19 vaccine

A new study assesses antibody and functional T-cell responses at 6 months after complete vaccination with the Pfizer-BioNTech vaccine.

11 Oct 2021

The role of inhibiting palmitoylation of the SARS-CoV-2 spike protein on viral infectivity

It is demonstrated that palmitoylation of the first five cysteine residues of the C-terminal domain of the SARS-CoV-2 spike protein facilitates cell entry and the formation of syncytia.

11 Oct 2021

Vaccine-induced memory B cells can recognize SARS-CoV-2 variants

Researchers have been investigating the effect that memory B cells produced in individuals who have received an mRNA vaccine have against SARS-CoV-2 variants.

11 Oct 2021

Research finds different antibody responses following COVID vaccination and natural infection

A new study published in the journal Nature attempted to investigate memory B cell evolution 5 months after vaccination with mRNA vaccines such as Moderna (mRNA-1273) or Pfizer-BioNTech (BNT162b2) in SARS-CoV-2 naïve individuals. The study explored various aspects of memory B cell antibody response like neutralizing response, affinity, epitope targeting, and neutralizing breadth.

10 Oct 2021

Receptor News and Research

A survey on computational methods in discovering protein inhibitors of SARS-CoV-2

A mucoadhesive polymer with anti-SARS-COV-2 activity in vitro and in vivo

Taste loss as a COVID-19 symptom: a review

Vaccinated children induced significantly higher antibody titers than naturally SARS-CoV-2 infected children

Nucleoside modifications suppress the potential of RNA to activate dendritic cells

A new bacterial two-hybrid assay to study SARS-CoV-2 interactome

Analysis of SARS-CoV-2 Delta variant transmissibility across New England, USA

COVID-19 vaccination elicits broader antibody response to SARS-CoV-2 spike than infection

An investigation of SARS-CoV-2 infection in diabetic pregnancies

SARS-CoV-2 immune responses in nursing home residents after full vaccination with Pfizer-BioNTech COVID-19 vaccine

The role of inhibiting palmitoylation of the SARS-CoV-2 spike protein on viral infectivity

Vaccine-induced memory B cells can recognize SARS-CoV-2 variants

Research finds different antibody responses following COVID vaccination and natural infection

Phase I clinical trial of two Cuban recombinant protein COVID-19 vaccines

What impact does temperature have on SARS-CoV-2 M protein dynamics?

Lipids, COVID-19, and host immunity

Powerful neutralizing antibody against SARS-CoV-2 variants of concern

Role of S-acylation in SARS-CoV-2 infectivity

Study supports efficacy and safety of lung-selective nanotherapy against SARS-CoV-2 infection

mRNA vaccination associated with decreased risk of COVID-19 infection and hospitalization in U.S. veterans

Lab Matters host Harriet Gould on building a more connected lab community

The Critical Role of Sample Storage in Drug Discovery and Development

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

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