Signaling Pathway News and Research

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Dietary change could be a key to enhancing colon cancer treatment

A dietary change could be a key to enhancing colon cancer treatment, a new study from the University of Michigan Rogel Cancer Center finds.

20 Nov 2022

Study challenges a long-standing idea about the role of Hippo signaling in organ growth

The Hippo signaling pathway – a genetic program thought to play a central role in organ development – does not instruct normal organ growth in flies and mice, according to a new study.

20 Nov 2022

Mitochondria plays an important role in signal transduction in innate immune pathways

Mitochondria are primarily known as the powerhouse of the cell. However, these cellular organelles are required not only for providing energy: Professor Konstanze Winklhofer and her group at the Faculty of Medicine at Ruhr University Bochum, Germany, recently discovered that mitochondria play an important role in signal transduction in innate immune pathways.

17 Nov 2022

Study reveals novel therapeutic targets for airway relaxation

Bronchial constriction is what makes many lung diseases like asthma so dangerous. Researchers have discovered a new signaling pathway that causes the airways to widen.

17 Nov 2022

How mRNA vaccines work without an added adjuvant

In a recent study published in the Immunity journal, researchers explored the current knowledge of the mechanism employed by messenger ribonucleic acid (mRNA) vaccines to elicit innate immune activation.

13 Nov 2022

Genetic variant associated with slimness estimated to be present in almost 60% of the Europeans

How much do genes influence our body weight? For the general population this influence is around 20%, according to studies that in recent years have analyzed the complete genome of tens of thousands of people.

8 Nov 2022

Fermented dairy products can improve gut mucosal immunity

In a recent study published in the journal Immunology Letters, researchers assessed the role of fermented dairy products and dairy starters in modulating gut mucosal immunity.

3 Nov 2022

Study uncovers a control hub for skin inflammation

Inflammatory reactions in the skin can reduce damage from UV radiation or infections, but can also result in painful symptoms such as sunburn.

2 Nov 2022

Higher viscosity of extracellular fluid enhances cancer dissemination

New research findings show how higher viscosity, or resistance to flow, of the extracellular fluid that surrounds cells enables cancer cells to migrate more rapidly from a primary tumor to other sites in the body.

2 Nov 2022

Study identifies a new therapeutic strategy to tackle endometrial cancer

Inhibition of the ERK5 protein kinase reduces the proliferation and survival of endometrial cancer cells, and potentiates standard chemotherapy.

2 Nov 2022

Study finds possible treatment strategy for Feingold syndrome type 1

A decrease in protein synthesis in cells of the developing gut contributes to a rare genetic disorder, and an inexpensive nutritional supplement may help reverse that decrease, according to a new study publishing November 1st in the open access journal PLOS Biology by Yun-Fei Li of Zhejiang University School of Medicine in Hangzhou, China, and colleagues. The finding is an advance in understanding the pathogenesis of the disease, and may lead to new treatments.

2 Nov 2022

Researchers offer new insights into the neurobiological basis of autism spectrum disorders

Findings from a new study published in Cell Reports, involving a collaborative effort between researchers at the Luikart Laboratory at Dartmouth's Geisel School of Medicine and the Weston Laboratory at the University of Vermont, are providing further insight into the neurobiological basis of autism spectrum disorders (ASD) and pointing to possible treatments.

1 Nov 2022

UT Southwestern study uncovers a causative signaling pathway in breast cancer

UT Southwestern researchers have identified a causative signaling pathway in breast cancer, providing potential new targets for treatment of the most common type of cancer in women.

1 Nov 2022

Protein kinase CK2 controls CD8+ T cell effector and memory functions during Listeria infection

The protein kinase CK2 is involved in a wide range of biological processes and cellular functions, including inflammatory responses and pathologies associated with inflammation.

1 Nov 2022

New discovery may change the textbook model of GPCR-mediated signaling

Researchers at University of California San Diego have identified a new signaling process involving G protein-coupled receptors (GPCRs), a cellular target already exploited by hundreds of diverse drugs.

27 Oct 2022

Research reveals molecular pathways of aggressive cribriform prostate cancer

Cribriform prostate cancer is an aggressive subtype of the disease characterized by its histology, but little is known about its molecular pathways.

26 Oct 2022

Swine acute diarrhea syndrome coronavirus promotes replication by inducing autophagy

The swine acute diarrhea syndrome coronavirus promotes autophagy to maintain its replication inside host cells.

26 Oct 2022

Booster vaccinations in the elderly lead to impaired neutralization of SARS-CoV-2 and atypical B cells

Researchers examine neutralizing antibody responses against SARS-CoV-2 in elderly individuals who received one mRNA booster dose.

23 Oct 2022

Male mice three times more likely than females to survive E. coli infection

Scientists at UC San Francisco have developed a new way of looking at sex-biased diseases that is rooted in evolutionary biology.

20 Oct 2022

Pathophysiological mechanisms of COVID-19-related endothelial dysfunction and potential therapies

Researchers discussed the pathophysiological mechanisms of endothelial dysfunction associated with severe coronavirus disease 2019 (COVID-19) and commented on the potential therapeutic strategies to treat endothelial damage and coagulopathy related to COVID-19.

19 Oct 2022

Signaling Pathway News and Research

Dietary change could be a key to enhancing colon cancer treatment

Study challenges a long-standing idea about the role of Hippo signaling in organ growth

Mitochondria plays an important role in signal transduction in innate immune pathways

Study reveals novel therapeutic targets for airway relaxation

How mRNA vaccines work without an added adjuvant

Genetic variant associated with slimness estimated to be present in almost 60% of the Europeans

Fermented dairy products can improve gut mucosal immunity

Study uncovers a control hub for skin inflammation

Higher viscosity of extracellular fluid enhances cancer dissemination

Study identifies a new therapeutic strategy to tackle endometrial cancer

Study finds possible treatment strategy for Feingold syndrome type 1

Researchers offer new insights into the neurobiological basis of autism spectrum disorders

UT Southwestern study uncovers a causative signaling pathway in breast cancer

Protein kinase CK2 controls CD8+ T cell effector and memory functions during Listeria infection

New discovery may change the textbook model of GPCR-mediated signaling

Research reveals molecular pathways of aggressive cribriform prostate cancer

Swine acute diarrhea syndrome coronavirus promotes replication by inducing autophagy

Booster vaccinations in the elderly lead to impaired neutralization of SARS-CoV-2 and atypical B cells

Male mice three times more likely than females to survive E. coli infection

Pathophysiological mechanisms of COVID-19-related endothelial dysfunction and potential therapies

How Omics Technologies Are Transforming Biological Research and Drug Discovery

How microplastics and bacteria interact to drive antibiotic resistance

Single-cell proteomics: Revealing proteome diversity from cellular heterogeneity to non-canonical biology

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