Transcriptomics News and Research

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Exosomes: The cancer cell communication mechanism

Professor Deborah Goberdhan speaks to News-Medical about her team's latest research into cancer cells, and the mechanisms they use to communicate.

26 Aug 2020

Combining expertise in organoids and sequencing technologies for ALS research

MDC researchers received a $150,000 pilot project grant from the Chan Zuckerberg Initiative's Neurodegeneration Challenge Network to investigate a defining feature of amyotrophic lateral sclerosis (ALS).

20 Aug 2020

Membrane nanoparticles acts as a bait to trap SARS-CoV-2

In an exciting new bioRxiv preprint research paper, Chinese researchers describe the development of membrane nanoparticles from ACE2-rich cells with a potent capacity to block the adherence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

13 Aug 2020

Study provides comprehensive update on ACE2 enzyme with key role in SARS-CoV-2 infection

Researchers at Uppsala University have described the presence, throughout the human body, of the enzyme ACE2.

5 Aug 2020

New method reveals the dynamics of cell development and gene activity

Traditional single-cell sequencing methods help to reveal insights about cellular differences and functions - but they do this with static snapshots only rather than time-lapse films.

4 Aug 2020

Study reveals multiple characteristics of HIV-1-producing cells in vivo

For eradication of HIV-1 infection, it is important to elucidate the detailed features and heterogeneity of HIV-1-infected cells in vivo.

29 Jul 2020

Amyloid plaques may act as trigger for Alzheimer's disease

The brains of people living with Alzheimer's are riddled with plaques: protein aggregates consisting mainly of amyloid-beta.

23 Jul 2020

Drug discovery pipeline to exploit transcription factors for cancer therapy

Cancer is a leading cause of death and one of the most complex challenges to modern medicine. By employing cutting-edge technologies that precisely measure the effects of candidate targets and drugs on the fundamental process of transcription, the new start-up company QUANTRO Therapeutics strives to radically change the precision and scope of cell-based drug screening.

21 Jul 2020

An abundance of biomolecules linked to COVID-19 status and severity

Tapping into the potential of the multi-omic method to uncover functional connections between various classes of biomolecules, researchers from notable institutions in the United States have discovered sets of co-varying molecules that shed light on coronavirus disease (COVID-19) pathophysiology and provide treatment opportunities.

20 Jul 2020

Use of whole blood transcriptomes may improve COVID-19 diagnosis and treatment

In a new paper published on the preprint server medRxiv*, a multinational group of researchers provide the first evidence for the use of whole blood transcriptomics to distinguish coronavirus disease (COVID-19) from other infections, and also to monitor and potentially predict disease outcomes.

9 Jul 2020

Researchers develop new atlas for mapping brain regions

In a new study researchers at Karolinska Institutet and KTH Royal Institute of Technology in Sweden have developed a new kind of brain atlas based on an innovative method of mapping brain tissue into areas according to their molecular profile

29 Jun 2020

SARS-CoV-2 can replicate in human pediatric gastric organoids

A diverse research group from the United Kingdom, Italy, China, and Australia established a first expandable human gastric organoid culture across fetal developmental stages, supporting the hypothesis that fetal tissue seems to be much less susceptible to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection – especially in the early stages of development.

25 Jun 2020

Creating the first 3D neural map of a heart

News-Medical spoke to Dr. Vadigepalli and Dr. Schwaber about their groundbreaking research in which they managed to map the neurons in the heart.

15 Jun 2020

Researchers use single-cell-resolution technologies to map brain genes in humans

A group of scientists led by Philipp Khaitovich, a professor at Skoltech, conducted a large-scale study of gene expression in 33 different brain regions of humans, chimpanzees, macaques and bonobos using the single-cell-resolution transcriptomics technologies and made a map of the different brain regions with their specific cell structures.

5 Jun 2020

Explosion of immune cells in mouse lungs after birth may help protect against infections

An explosion in the number and types of immune cells in the lungs of newborn mice likely helps them adapt to breathing and protects them from infection, says a new study published today in eLife.

2 Jun 2020

AstraZeneca implements Genestack’s flagship Omics Data Manager

Genestack Ltd. today announced that its flagship multi-omics data catalogue, curation and integrative search product, Omics Data Manager (ODM), has been licensed and implemented by AstraZeneca.

30 May 2020

3D model displays arrangement of intrinsic neurons in the rat heart

An interdisciplinary team of researchers has developed a virtual 3D heart, digitally showcasing the heart's unique network of neurons for the first time.

26 May 2020

Malaria's characteristic cycle of fever and chills is a result of parasite's own influence

Scientists from the Walter Reed Army Institute of Research joined partners at Duke University, Florida Atlantic University and Montana State University to publish a study providing clear evidence that malaria's characteristic cycle of fever and chills is a result of the parasite's own influence--not factors from the host.

15 May 2020

A 'multi-omics' approach to the development of drugs against COVID-19

A new study published on the preprint server medRxiv* in May 2020 reports a multi-omics approach that could make it easier to develop drugs that are effective against COVID-19.

12 May 2020

Single-cell RNA-seq addresses key question in islet cell biology and diabetes research

The pancreas is an abdominal organ that produces digestive enzymes as well as hormones that regulate blood sugar levels. This hormone-producing function is localized to the islets of Langerhans, which constitute clusters of different endocrine cell types.

12 May 2020