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Persistence of humoral immune response in SARS-CoV-2 convalescent individuals a year after infection

A new study reported the persistence of immune responses over twelve months after natural infection.

1 Oct 2021

Novel Assay Platform for 3D Microfluidic Cancer Research

AMSBIO have supplied custom Chimeric antigen receptor (CAR)-T products to the University of Strathclyde (UoS) in Glasgow, UK, and ScreenIn3D Ltd, allowing them to perform novel immune-oncology assays in 3D microfluidic cancer models.

From AMS Biotechnology 1 Oct 2021

Study finds US pediatric COVID-19 cases are higher than expected

Researchers from the CDC have investigated differences in seroprevalence across pediatric age groups to estimate an infection to case ratio.

1 Oct 2021

New approach reveals ‘protein partners’ that may contribute to unusual pathologies of COVID-19

COVID-19 not only causes symptoms characteristic of a typical respiratory disorder, but has also been known to trigger a wide range of other symptoms in people who had been infected, some lasting even long after individuals test negative for the virus.

30 Sep 2021

Non-severe COVID-19 may elicit more durable memory B cell response than severe COVID-19

A recent study conducted by researchers from the US aimed to measure the impact of severity of COVID-19 on memory B cell response and characterize changes in the memory B cell compartment during the period between recovery and five months after symptom onset. This study is available on the bioRxiv* preprint server.

30 Sep 2021

Study reveals how to improve overall immune response against virally driven cancers

Blocking the PD-1 inhibitory pathway within a subset of specialized T-cells may improve overall immune response against virally driven cancers, according to findings published in Nature.

30 Sep 2021

New system synthetically reconnects neural circuits using neuropeptides from Hydra

For two people to communicate in a loud, crowded room, they need to be standing side by side. The same is often true for neurons in the brain. But the same way a cell phone allows two people to communicate clearly across the room, new research at the Marine Biological Laboratory (MBL) opened up a new channel of communication in the worm C. elegans brain.

30 Sep 2021

SARS-CoV-2 infection aided by antibody-dependent enhancement

The coronavirus disease 2019 (COVID-19) pandemic has raised concerns about the detrimental effects of antibodies. Antibody-dependent enhancement (ADE) of infection is one of the biggest concerns in terms of not only the antibody reaction to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) upon reinfection with the virus but also the reaction to COVID-19 vaccines.

30 Sep 2021

Novel framework can predict changes that may increase the infectiousness of SARS-CoV-2

As SARS-CoV-2 continues to evolve, new variants are expected to arise that may have an increased ability to infect their hosts and evade the hosts' immune systems.

29 Sep 2021

Research points to new opportunities to prevent treatment resistance in fragile X syndrome

Mark Bear, Picower Professor of Neuroscience at MIT, recalls the "eureka moment" 20 years ago when he realized that a severe developmental brain disorder - fragile X syndrome - might be treated with drugs that inhibit a neurotransmitter receptor called mGluR5.

29 Sep 2021

Immunocompromised patients show decreased response to SARS-CoV-2 mRNA vaccines

Researchers explore the germinal cell responses in both healthy individuals and kidney transplant patients in their recent study.

29 Sep 2021

Study finds strong evidence of transplacental passage of IgG antibodies following COVID vaccination

In the current study, researchers investigate the transplacental transmission of antibodies in vaccinated pregnant women.

29 Sep 2021

Study investigates the mechanism underlying kidney damage in COVID-19 patients

A review article published in the journal Frontiers in Physiology by researchers affiliated with the Federal University of São Paulo in Brazil discusses the mechanisms whereby SARS-CoV-2 damages the kidneys, potentially serving as a basis for further research in pursuit of treatments to prevent severe renal problems and even chronic kidney disease in COVID-19 patients.

29 Sep 2021

Clinical dilemmas in breast cancer patients solved by newly approved PET imaging agent

A non-invasive, patient-friendly imaging technique can help physicians make treatment decisions for breast cancer patients when diagnostic dilemmas arise.

29 Sep 2021

Large-scale SARS-CoV-2 spike protein mutants analysis identifies subclonal variants indicative of within-host viral diversity

Researchers have investigated a vast SARS-CoV-2 assembly and NGS data set to detect non-synonymous S protein mutations.

29 Sep 2021

Study finds correlation between neutralizing antibody titer and reported vaccine efficacy

An observational study compares immune responses against three vaccines.

29 Sep 2021

Vaccine-induced SARS-CoV2 immune responses decline at similar rates as those after infection, study finds

A new preprint describes the causal role of waning antibody titers in decreased antibody persistence at one year.

29 Sep 2021

New analysis reveals distinct differences between molecular profiles of 3D and 2D cultured cells

Oncotarget published "Comparative microsomal proteomics of a model lung cancer cell line NCI-H23 reveals distinct differences between molecular profiles of 3D and 2D cultured cells" which reported that to ascertain phenotypical differences between these two distinct culture conditions, these authors carried out a comparative proteomic analysis of a membrane fraction obtained from 3D- and 2D-cultured NSCLC model cell line NCI-H23.

29 Sep 2021

Research provides the basis for an additional novel immunotherapy for multiple myeloma patients

Oncotarget published "Multipeptide stimulated PBMCs generate TEM/TCM for adoptive cell therapy in multiple myeloma" which reported that Multiple Myeloma patients suffer disease relapse due to the development of therapeutic resistance. Increasing evidence suggests that immunotherapeutic strategies can provide durable responses.

29 Sep 2021

Combination of two drugs may help pancreatic and liver cancer patients

A drug candidate discovered and developed decades ago in the laboratory of UC Davis distinguished professor Bruce Hammock may help control the body's raging and often deadly inflammatory response to chemotherapy treatments, especially for pancreatic and liver cancer patients.

29 Sep 2021

Receptor News and Research

Persistence of humoral immune response in SARS-CoV-2 convalescent individuals a year after infection

Novel Assay Platform for 3D Microfluidic Cancer Research

Study finds US pediatric COVID-19 cases are higher than expected

New approach reveals ‘protein partners’ that may contribute to unusual pathologies of COVID-19

Non-severe COVID-19 may elicit more durable memory B cell response than severe COVID-19

Study reveals how to improve overall immune response against virally driven cancers

New system synthetically reconnects neural circuits using neuropeptides from Hydra

SARS-CoV-2 infection aided by antibody-dependent enhancement

Novel framework can predict changes that may increase the infectiousness of SARS-CoV-2

Research points to new opportunities to prevent treatment resistance in fragile X syndrome

Immunocompromised patients show decreased response to SARS-CoV-2 mRNA vaccines

Study finds strong evidence of transplacental passage of IgG antibodies following COVID vaccination

Study investigates the mechanism underlying kidney damage in COVID-19 patients

Clinical dilemmas in breast cancer patients solved by newly approved PET imaging agent

Large-scale SARS-CoV-2 spike protein mutants analysis identifies subclonal variants indicative of within-host viral diversity

Study finds correlation between neutralizing antibody titer and reported vaccine efficacy

Vaccine-induced SARS-CoV2 immune responses decline at similar rates as those after infection, study finds

New analysis reveals distinct differences between molecular profiles of 3D and 2D cultured cells

Research provides the basis for an additional novel immunotherapy for multiple myeloma patients

Combination of two drugs may help pancreatic and liver cancer patients

Lab Matters host Harriet Gould on building a more connected lab community

The Critical Role of Sample Storage in Drug Discovery and Development

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

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