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Plasma ABO protein is a causal risk factor for severe COVID-19

Researchers used an integrative genomics approach to find the genes responsible for COVID-19 and its severity.

7 Oct 2020

Proteolytic cleavage of nucleocapsid helps SARS-CoV-2 evade host immune responses

A team of scientists of the University of Oxford reveals that the nucleocapsid protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) undergoes autoproteolysis, and that resulting products can escape the host immune responses and facilitate viral proliferation. The study is currently available on the bioRxiv preprint server.

7 Oct 2020

SARS-CoV-2 infection analysis could help fight against COVID-19

Researchers in the United States has provided a detailed catalog of the interactions that occur between host cell proteins and RNA and the RNA of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) during the course of infection.

7 Oct 2020

Theoretical model explains biological phenomena that keep bacteria in shape

Fat bacteria? Skinny bacteria? From our perspective on high, they all seem to be about the same size. In fact, they are.Precisely why has been an open question, according to Rice University chemist Anatoly Kolomeisky, who now has a theory.

7 Oct 2020

Case report of arthritis in a COVID-19 patient

The current paper published in the The Lancet Rheumatology discusses arthritis in a 58-year-old white woman with COVID-19 of less than severe intensity.

7 Oct 2020

Sofosbuvir combined with other antivirals is more effective against COVID-19, shows study

Columbia Engineering researchers report that Sofosbuvir-terminated RNA is more resistant to the proofreader of SARS-CoV-2, the virus that causes COVID-19, than Remdesivir-terminated RNA.

7 Oct 2020

Study determines frequency and patterns of T-cell escape mutations in HIV patients undergoing antiretroviral therapy

Immune cells that can recognize residual HIV-infected cells in people living with HIV (PLWH) who take antiretroviral therapy (ART) remain active for years, says a new study published today in eLife.

7 Oct 2020

Proteolytic activation of the SARS-CoV-2 spike S1/S2 site

In a recent paper published on the bioRxiv preprint server, Cornell University researchers study the proteolytic activation of the SARS-CoV-2 spike sites, re-evaluating the furin cleavage.

6 Oct 2020

Using GWAS and trans-ancestry comparison to accurately predict risk for coronary artery disease

An international group led by researchers from the RIKEN Center for Integrative Medical Sciences have used a combination of genome-wide association analysis--or GWAS--and a trans-ancestry comparison of different GWAS studies, to come up with a more accurate predictor of coronary artery disease based on genetic factors.

6 Oct 2020

UChicago genomics researcher wins NIH Director's New Innovator Award

Oni Basu, PhD, an assistant professor of genetic medicine at the University of Chicago, has received the prestigious National Institutes of Health Director's New Innovator Award.

6 Oct 2020

Multi-ancestry comparison can accurately predict risk factors for coronary artery disease

An international group led by researchers from the RIKEN Center for Integrative Medical Sciences have used a combination of genome-wide association analysis—or GWAS—and a trans-ancestry comparison of different GWAS studies, to come up with a more accurate predictor of coronary artery disease based on genetic factors.

6 Oct 2020

SARS-CoV-2 and anti-COVID-19 drugs activate Kaposi sarcoma-associated herpesvirus

A new study published on the preprint server bioRxiv* aimed to investigate the impacts of COVID-19 on people with various illnesses. Specifically, the researchers at the Rockefeller Cancer Institute, and the University of Arkansas for Medical Sciences wanted to see the effects of COVID-19 on patients with cancer and other infectious diseases.

6 Oct 2020

Cancer mutations are found in distinct regions that vary based on genomic structure and mutation

A new study from researchers at The University of Texas MD Anderson Cancer Center has discovered that mutations found in cancers do not accumulate randomly, but are found in distinct patterns that vary based on the three-dimensional organization of the genome in the cell as well as the underlying factors causing the mutations

6 Oct 2020

Researchers identify gene related to seed dispersal in green millet

For years, Elizabeth (Toby) Kellogg, PhD, member and Robert E. King Distinguished Investigator and other researchers at the Donald Danforth Plant Science Center (Danforth Center) drove up and down the highways of the continental United States, occasionally pulling over to the side of the road to collect small weedy plants and bring them back to the lab.

6 Oct 2020

Development of a coarse-grained model of SARS-CoV-2 virion

A team of scientists of the University of Chicago and the University of California San Diego has developed a coarse-grained (CG) model of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virion. The model can be used as a valuable resource to perform multiscale simulations of the SARS-CoV-2 virion. The study is currently available on the bioRxiv* preprint server.

5 Oct 2020

New findings could improve investigation of T cell response to COVID-19

Researchers in the United States have made an important discovery about the processing and presentation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral peptides that provides a better understanding of the immune response to coronavirus disease 2019 (COVID-19) and may help facilitate the design of improved vaccines.

5 Oct 2020

FDA and Mexican regulatory counterparts strengthen partnership on food safety

Today, during a virtual ceremony, the U.S. Food and Drug Administration and its regulatory counterparts in Mexico - the Federal Commission for the Protection from Sanitary Risks and the National Service of Agro-Alimentary Health, Safety and Quality - enhanced a partnership to work together on food safety in both countries.

5 Oct 2020

Midges and mosquitoes unlikely to spread SARS-CoV-2

A recent study published on the preprint server bioRxiv* in September 2020 looked to see if biting insects pose a risk for transmission of SARS-CoV-2 to humans or animals following a SARS-CoV-2 infected blood meal.

5 Oct 2020

More evidence Pangolin not intermediary in transmission of SARS-CoV-2 to humans

The team proposed a different model named the ‘circulation model’ to illustrate how SARS-CoV-2-related coronaviruses could have circulated in different species, including humans, before COVID-19 emerged.

4 Oct 2020

Rapid detection of SARS-CoV-2 with portable CRISPR-based mobile phone diagnostic test

A large group of researchers from the United States reported developing an amplification-free CRISPR-based mobile phone assay for direct detection of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) from nasal swabs. Their state-of-the-art paper is currently available on the medRxiv* preprint server.

4 Oct 2020

Genome News and Research

Plasma ABO protein is a causal risk factor for severe COVID-19

Proteolytic cleavage of nucleocapsid helps SARS-CoV-2 evade host immune responses

SARS-CoV-2 infection analysis could help fight against COVID-19

Theoretical model explains biological phenomena that keep bacteria in shape

Case report of arthritis in a COVID-19 patient

Sofosbuvir combined with other antivirals is more effective against COVID-19, shows study

Study determines frequency and patterns of T-cell escape mutations in HIV patients undergoing antiretroviral therapy

Proteolytic activation of the SARS-CoV-2 spike S1/S2 site

Using GWAS and trans-ancestry comparison to accurately predict risk for coronary artery disease

UChicago genomics researcher wins NIH Director's New Innovator Award

Multi-ancestry comparison can accurately predict risk factors for coronary artery disease

SARS-CoV-2 and anti-COVID-19 drugs activate Kaposi sarcoma-associated herpesvirus

Cancer mutations are found in distinct regions that vary based on genomic structure and mutation

Researchers identify gene related to seed dispersal in green millet

Development of a coarse-grained model of SARS-CoV-2 virion

New findings could improve investigation of T cell response to COVID-19

FDA and Mexican regulatory counterparts strengthen partnership on food safety

Midges and mosquitoes unlikely to spread SARS-CoV-2

More evidence Pangolin not intermediary in transmission of SARS-CoV-2 to humans

Rapid detection of SARS-CoV-2 with portable CRISPR-based mobile phone diagnostic test

Genetics & Genomics - Second Edition eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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