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Pyruvate kinase M2 fuels tumor growth by influencing H3 histone protein

A metabolic protein that nourishes cancer cells also activates tumor-promoting genes by loosening part of the packaging that entwines DNA to make up chromosomes, a team led by scientists at The University of Texas MD Anderson Cancer Center reports in the Aug. 16 issue of Cell.

17 Aug 2012

Rhomboid enzymes and malaria treatment: an interview with Sinisa Urban

Rhomboid enzymes live in the cell’s membrane where their job is to cut the anchors of proteins, which releases the target proteins from the membrane.

16 Aug 2012

RNA-delivering nanoparticles allow rapid screening of new drug targets in mice

By sequencing cancer-cell genomes, scientists have discovered vast numbers of genes that are mutated, deleted or copied in cancer cells. This treasure trove is a boon for researchers seeking new drug targets, but it is nearly impossible to test them all in a timely fashion.

16 Aug 2012

Pathway describes how alpha hydroxyl acids cause skin exfoliation

A team of investigators from UC Davis and Peking University have discovered a mechanism that may explain how alpha hydroxyl acids (AHAs) -- the key ingredient in cosmetic chemical peels and wrinkle-reducing creams -- work to enhance skin appearance. An understanding of the underlying process may lead to better cosmetic formulations as well as have medical applications.

14 Aug 2012

Scientists develop new way to study role of GABA-A receptors in various disorders

A new way to study the role of a critical neurotransmitter in disorders such as epilepsy, anxiety, insomnia, depression, schizophrenia, and alcohol addiction has been developed by a group of scientists led by Gong Chen, an associate professor of biology at Penn State University.

9 Aug 2012

Theranostic imaging targets and tracks potent drug therapies to prostate cancer cells

Experimenting with human prostate cancer cells and mice, cancer imaging experts at Johns Hopkins say they have developed a method for finding and killing malignant cells while sparing healthy ones.

9 Aug 2012

Berlin Heart EXCOR Pediatric Ventricular Assist Device proves effective and life-saving

A tiny heart pump that maintains blood flow in babies and small children with serious heart failure proved effective and life-saving in a pioneering study involving 17 institutions led by Texas Children's Hospital and Baylor College of Medicine (BCM).

9 Aug 2012

Interface zone fibroblasts play key role in gastric cancer

Interface zone fibroblasts in gastric adenocarcinoma promote the invasion, migration, and proliferation of cancer cells, as well as prevent apoptosis, to a greater degree than normal or tumor zone fibroblasts, say researchers.

8 Aug 2012

Prostate cancer cells can be killed by theranostic imaging without harming healthy cells

Experimenting with human prostate cancer cells and mice, cancer imaging experts at Johns Hopkins say they have developed a method for finding and killing malignant cells while sparing healthy ones.

8 Aug 2012

Studies identify genetic mutations that play important roles in startle disease

Two studies published in the Journal of Biological Chemistry identify genetic mutations that play important roles in the condition commonly referred to as startle disease. Startle disease is characterized by an exaggerated response to noise and touch, which can interfere with breathing, cause catastrophic falls and even result in death.

8 Aug 2012

Common anti-angina drug may help protect the heart against carbon monoxide poisoning

An international research team, led from the University of Leeds, has found that a common anti-angina drug could help protect the heart against carbon monoxide poisoning.

6 Aug 2012

B-cell substances may play a role in MS progression

Wayne State University School of Medicine researchers, working with colleagues in Canada, have found that one or more substances produced by a type of immune cell in people with multiple sclerosis (MS) may play a role in the disease's progression. The finding could lead to new targeted therapies for MS treatment.

2 Aug 2012

Researchers discover genetic process that can restore function to a CF defective protein

Researchers at the University of Iowa Carver College of Medicine have discovered a genetic process that can restore function to a defective protein, which is the most common cause of cystic fibrosis (CF).

2 Aug 2012

Scientists decode stability blueprint of rhomboid enzyme

Johns Hopkins scientists have decoded for the first time the "stability blueprint" of an enzyme that resides in a cell's membrane, mapping which parts of the enzyme are important for its shape and function.

1 Aug 2012

Mapping rhomboid enzymes could eventually lead to drugs to treat malaria

31 Jul 2012

Sinai Hospital to help investigate health and safety of astronauts in long-duration spaceflight

Sinai Hospital of Baltimore has been awarded one of 29 grants by the National Space Biomedical Research Institute (NSBRI) and NASA's Human Research Program to help investigate questions about astronaut health and performance on future deep-space exploration missions.

31 Jul 2012

Two new targets could enhance the body's defenses against West Nile and hepatitis C

Two new targets have been discovered for antiviral therapies and vaccines strategies that could enhance the body's defenses against such infectious diseases as West Nile and hepatitis C. The targets are within the infection warning system inside living cells.

31 Jul 2012

Bruker introduces high-resolution microscope for research in biological dynamics

At the Microscopy & Microanalysis (M&M) 2012 Annual Meeting, Bruker today announced the Dimension FastScan Bio™ Atomic Force Microscope (AFM), which enables high-resolution microscopy research in biological dynamics.

From Bruker Nano Surfaces and Metrology 30 Jul 2012

Study validates importin beta1 protein's crucial role in nerve repair

Several years ago, Prof. Michael Fainzilber and his group in the Biological Chemistry Department made a surprising discovery: Proteins thought to exist only near the cell nucleus could also be found in the far-off regions of the body's longest cells - peripheral nerve cells that extend processes called axons, reaching up to a meter in length in adult humans.

27 Jul 2012

A2bAR receptor plays a significant role in regulation of type 2 diabetes and obesity

A recent study led by Boston University School of Medicine (BUSM) demonstrates that the A2b-type adenosine receptor, A2bAR, plays a significant role in the regulation of high fat, high cholesterol diet-induced symptoms of type 2 diabetes.

27 Jul 2012

Membrane News and Research

Pyruvate kinase M2 fuels tumor growth by influencing H3 histone protein

Rhomboid enzymes and malaria treatment: an interview with Sinisa Urban

RNA-delivering nanoparticles allow rapid screening of new drug targets in mice

Pathway describes how alpha hydroxyl acids cause skin exfoliation

Scientists develop new way to study role of GABA-A receptors in various disorders

Theranostic imaging targets and tracks potent drug therapies to prostate cancer cells

Berlin Heart EXCOR Pediatric Ventricular Assist Device proves effective and life-saving

Interface zone fibroblasts play key role in gastric cancer

Prostate cancer cells can be killed by theranostic imaging without harming healthy cells

Studies identify genetic mutations that play important roles in startle disease

Common anti-angina drug may help protect the heart against carbon monoxide poisoning

B-cell substances may play a role in MS progression

Researchers discover genetic process that can restore function to a CF defective protein

Scientists decode stability blueprint of rhomboid enzyme

Mapping rhomboid enzymes could eventually lead to drugs to treat malaria

Sinai Hospital to help investigate health and safety of astronauts in long-duration spaceflight

Two new targets could enhance the body's defenses against West Nile and hepatitis C

Bruker introduces high-resolution microscope for research in biological dynamics

Study validates importin beta1 protein's crucial role in nerve repair

A2bAR receptor plays a significant role in regulation of type 2 diabetes and obesity

Event guide: 4th Extra-Hepatic Lipid-Based Nanoparticles Delivery Summit eBook

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