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SLU researchers reveal how to turn off neuropathic pain in a laboratory setting

Facing an urgent need for safer and more effective therapies for those suffering from debilitating pain in the midst of an opioid crisis, Saint Louis University researchers are on a mission to find a non-narcotic off-switch for pain.

10 May 2019

Penn study reveals link between mitochondrial damage and osteoporosis

Some risk factors for osteoporosis such as being older and female or having a family history of the condition cannot be avoided. But others can, like smoking cigarettes, consuming alcohol, taking certain medications, or being exposed to environmental pollutants.

9 May 2019

New drug targeting genetic weakness could become first treatment for childhood brain cancer

A new type of drug that targets a genetic weakness in an untreatable childhood brain cancer could become the first ever treatment designed to target the disease.

9 May 2019

Promising radioisotope couple for cancer diagnosis and therapy

Researchers at Kanazawa University report in ACS Omega a promising combination of radioisotope-carrying molecules for use in radiotheranostics — a diagnosis-and-treatment approach based on the combination of medical imaging and internal radiation therapy with radioactive elements.

9 May 2019

Small molecule drug may help overcome ibrutinib resistance in mantle cell lymphona

A study at The University of Texas MD Anderson Cancer Center demonstrated how a small molecule drug discovered at the institution may help overcome resistance to treatment with ibrutinib in patients with mantle cell lymphoma.

9 May 2019

Compound derived from broccoli sprouts may restore brain chemistry imbalance related to schizophrenia

In a series of recently published studies using animals and people, Johns Hopkins Medicine researchers say they have further characterized a set of chemical imbalances in the brains of people with schizophrenia related to the chemical glutamate.

From Johns Hopkins Medicine 9 May 2019

Inhibition of ribosome biogenesis as new treatment strategy for advanced cancers

Nearly ninety per cent of all cancer patient deaths are due to metastasis. A study from Uppsala University shows that a process that allows the cells to metastasize is aided by the synthesis of new ribosomes, the cell components in which proteins are produced.

8 May 2019

Scientific research articles show that imipridones target mitochondrial function in cancer cells

Oncoceutics, Inc. announced the publication of two scientific research articles demonstrating that members of the imipridone family ONC201 and ONC212 directly activate a mitochondrial protease called caseinolytic protease P.

7 May 2019

Researchers develop new molecule that binds to the cerebrovascular system

Brazilian and US researchers have developed a molecule called FRW that, in tests with mice, proved capable of binding to blood vessels in the brain but not in other organs when injected into the bloodstream.

7 May 2019

Research in preclinical models suggests promising anti-HIV-1 vaginal microbicide

A vaginal microbicide that could prevent sexual transmission of HIV-1 in women has tremendous potential for saving lives and helping staunch an epidemic.

7 May 2019

Low oxygen levels harm specific cells in the developing brain

Low oxygen levels are a well-known cause of brain injury in premature babies. But the mechanism by which low oxygen hurts the developing human brain has been unclear.

6 May 2019

Discovery of small-molecule inhibitors could enable precise control over CRISPR-Cas9 genome editing

The discovery of the first small-molecule inhibitors of the Streptococcus pyogenes Cas9 (SpCas9) protein could enable more precise control over CRISPR-Cas9-based genome editing, researchers report May 2 in the journal Cell.

3 May 2019

Novel chemical probe enables live imaging of brain immune cells

Researchers in South Korea and Singapore have, for the first time, developed a chemical probe that enables live-imaging of a type of immune cells in the brain, known as microglia, in a live animal brain.

3 May 2019

Researchers uncover new brain mechanisms regulating body weight

Researchers at University of Gothenburg, Sweden, clarify the link between the molecule interleukine-6 (IL-6) in the brain and obesity. In experiments on rats and mice they show that the molecule does affect the risk of obesity, and also where this effect occurs in the brain.

2 May 2019