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Zipper motif mediates SARS-CoV-2 spike trimerization within host cell membrane

A new preprint research paper posted to the bioRxiv* server describes the results of a nuclear magnetic resonance (NMR) study to determine the structure of the S protein transmembrane domain (TMD) and its membrane-proximal regions.

13 Apr 2021

Psychedelic drugs may work in multiple ways in the brain

University of Maryland School of Medicine (UMSOM) researchers have shown that psilocybin—the active chemical in “magic mushrooms”— still works its antidepressant-like actions, at least in mice, even when the psychedelic experience is blocked.

13 Apr 2021

PCR-based reverse genetic system helps analyze SARS-CoV-2 mutations

SARS-CoV-2 is the virus responsible for the COVID-19 pandemic. We know that mutations in the genome of SARS-CoV-2 have occurred and spread, but what effect do those mutations have?

13 Apr 2021

People who experience big dips in blood sugar levels consume more calories

New research shows that people who experience big dips in blood sugar levels, several hours after eating, end up feeling hungrier and consuming hundreds more calories during the day than others.

13 Apr 2021

Adequate levels of antioxidants may reduce HPV infection linked to cervical cancer development

A study led by Hui-Yi Lin, Ph.D., Professor of Biostatistics, and a team of researchers at LSU Health New Orleans Schools of Public Health and Medicine has found that adequate levels of five antioxidants may reduce infection with the strains of the human papillomavirus (HPV) associated with cervical cancer development.

13 Apr 2021

Comprehensive medication management delivered by pharmacists supports primary care

Evidence is growing that health care delivered by teams is superior to services delivered by a single practitioner.

13 Apr 2021

Pandemic has triggered changes in mental health and physical activity

New research from McMaster University suggests the pandemic has created a paradox where mental health has become both a motivator for and a barrier to physical activity.

13 Apr 2021

New algorithm can predict which genes cause cancer

A new algorithm can predict which genes cause cancer, even if their DNA sequence is not changed. A team of researchers in Berlin combined a wide variety of data, analyzed it with "Artificial Intelligence" and identified numerous cancer genes.

13 Apr 2021

CityMD experience during the coronavirus pandemic in New York City

Limiting SARS-CoV-2 transmission requires an infected person to quarantine themselves for at least two weeks. New research published on the medRxiv* server highlights the vital role urgent care centers play during the COVID-19 pandemic in New York.

13 Apr 2021

Overuse can contribute to high rate of arm injuries among youth players

With spring baseball season underway, Eric Makhni, M.D., a Henry Ford Health System sports medicine orthopedic surgeon, warns about how overuse can contribute to the high rate of arm injuries among youth players.

13 Apr 2021

Researchers identify new potential mechanism for age-related macular degeneration

Using laboratory-grown roundworms as well as human and mouse eye tissue, University of Maryland School of Medicine (UMSOM) researchers have identified a new potential mechanism for age-related macular degeneration - the leading cause of blindness among older adults.

13 Apr 2021

Inhibition of nsp14 methyltransferase as a potential antiviral target for SARS-CoV-2

Beyond vaccination, the broad-spectrum antiviral medication remdesivir has robust clinical evidence and is known as the best antiviral treatment to reduce severe COVID-19 infection in hospitalized patients. Research led by John F.X. Diffley of the Chromosome Replication Laboratory suggests a potential therapeutic target for treatment development is the viral RNA cap methyltransferases, essential for viral protein translation and immune evasion.

13 Apr 2021

New technology shows encouraging results for treating osteosarcoma

A preclinical study led by researchers at The University of Texas MD Anderson Cancer Center shows an antibody-drug conjugate (ADC) targeting surface protein MT1-MMP can act as a guided missile in eradicating osteosarcoma tumor cells without damaging normal tissues.

13 Apr 2021

Could Zebrafish larvae be a novel animal model for SARS-CoV-2?

Researchers based in Paris, France, have explored the potential use of zebrafish larvae as animal models for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). These larvae are small and cheap, so could prove a suitable medium for rapid mass testing of the disease.

13 Apr 2021

Low health literacy may discourage men from selecting active surveillance for prostate cancer

Tumor gene profiling is a tool that can help patients with a cancer diagnosis make informed decisions about treatment.

13 Apr 2021

Americans are consuming poor nutritional quality food everywhere, except at school

Whether eating out or buying food from the grocery store, Americans of all ages are, for the most part, eating poorly everywhere - except at school.

13 Apr 2021

Melanoma mortality is higher in Utah than in any other state, shows report

A letter published today [April 8, 2021] by Huntsman Cancer Institute (HCI) at the University of Utah (U of U) in the New England Journal of Medicine reports that melanoma mortality among Utahns outpaced that of the rest of the United States during the period from 1975 to 2013.

12 Apr 2021

High SARS-CoV-2 vaccine effectiveness in California, even with variants

Researchers in the United States and the UK have conducted a study showing that the rollout of vaccines to protect against coronavirus disease 2019 (COVID-19) is proving effective among California's general population.

12 Apr 2021

Real-world evidence from Israel on VOCs and SARS-CoV-2 vaccine protection

A new study by Israeli researchers tested the hypothesis that certain SARS-CoV-2 variants of concern can overcome protection conferred by Pfizer-BioNTech (BNT162b2) mRNA vaccine and found evidence of increased breakthrough rates in vaccinated individuals. The research paper is currently available on the medRxiv preprint server.

12 Apr 2021

Study finds correlation between COVID-19 pandemic and six unhealthy eating behaviors

A new probe into the lingering impacts of the COVID-19 pandemic revealed correlations to six unhealthy eating behaviors, according to a study by the University of Minnesota Medical School and School of Public Health.

12 Apr 2021