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Penn Medicine, Wistar Institute awarded NCI grants for four new melanoma research projects

Penn Medicine and The Wistar Institute have been awarded a prestigious $12.1 million SPORE grant from the National Cancer Institute. The five-year Specialized Programs of Research Excellence, or SPORE, grant will fund four new melanoma research projects that aim to translate fundamental laboratory discoveries into new therapeutics to treat melanoma and other skin cancers.

18 Sep 2014

Study suggests potential treatment for cardiovascular disease in people with apoE4 gene variant

Researchers at UT-Southwestern Medical Center have found that the most common variant of the circulating protein apolipoprotein E, called apoE3, helps repair the lining of blood vessels. Individuals with another variant, called apoE4, do not get the benefit of this repair, putting them at higher risk for cardiovascular disease.

18 Sep 2014

Common type of hospital-associated infections can be prevented with vaccine

The most common type of hospital-associated infection may be preventable with a vaccine, new research in mice suggests.

18 Sep 2014

New approach to imaging metastatic tumors

Bioluminescence, nanoparticles, gene manipulation - these sound like the ideas of a science fiction writer, but, in fact, they are components of an exciting new approach to imaging local and metastatic tumors.

18 Sep 2014

UAB researchers discover novel mechanism involved in formation of memory, learning

Researchers at the University of Alabama at Birmingham report the discovery of a novel mechanism in the brain involved in the formation of memory and learning. In findings reported online this week in Nature, the research team describes the role of a histone subunit known as H2A.Z.

18 Sep 2014

Studies explore role of STXBP5 gene in development of cardiovascular disease

Two independent groups of researchers led by Sidney (Wally) Whiteheart, PhD, of the University of Kentucky, and Charles Lowenstein, MD, of the University of Rochester, have published important studies exploring the role that a gene called STXBP5 plays in the development of cardiovascular disease.

18 Sep 2014

Scientists find 23 new genetic variants that increase risk for prostate cancer

In an analysis of genetic information among more than 87,000 men, a global team of scientists says it has found 23 new genetic variants - common differences in the genetic code -- that increase a man's risk for prostate cancer. The so-called "meta-analysis," believed to be the largest of its kind, has revealed once hidden mutations among men in a broad array of ethnic groups comprising men of European, African, Japanese and Latino ancestry.

18 Sep 2014

Rosuvastatin promotes bone growth in mice with achondroplasia symptoms

Skeletal dysplasia is a group of rare diseases that afflict skeletal growth through abnormalities in bone and cartilage. Its onset hits at the fetal stage and is caused by genetic mutations.

18 Sep 2014

Disrupting cancer regulator MYC: an interview with Professor Kim Janda

MYC is an oncogenic member of the basic helix-loop-helix-leucine zipper transcription factor family. In its monomeric form, MYC’s tertiary structure is intrinsically disordered and the protein is transcriptionally inactive.

17 Sep 2014

S. pneumoniae drug susceptibility tracked in Japan

A 12-year survey of the antimicrobial susceptibility of Streptococcus pneumoniae isolates in Miyagi Prefecture in Japan has identified important changes, including improved susceptibility to β-lactam antibiotics.

17 Sep 2014

Isis receives $4 million in milestone payment from Achaogen for initiation of plazomicin Phase 3 study

Isis Pharmaceuticals, Inc. announced that it has earned a $4 million milestone payment from Achaogen, Inc. associated with the initiation of a Phase 3 study of plazomicin in patients with serious multi-drug resistant (MDR), gram-negative bacterial infections.

17 Sep 2014

UMass Amherst doctoral student in chemistry receives USP's 2014-15 Global Fellowship Award

University of Massachusetts Amherst doctoral student in chemistry Khaja Muneeruddin is one of three promising young scientists to recently receive the 2014-15 Global Fellowship Award from the United States Pharmacopeial Convention, dual publishers of the official pharmacopeia and National Formulary (NF), the book of directions for identifying compound medicines.

17 Sep 2014

NIH awards grant to scientist to link drugs, genes and diseases

The National Institutes of Health wants to make the process of finding new drugs faster and better. The effort will help all 27 of its research institutes and centers. So, the nation's medical research agency awarded Tudor Oprea, MD, PhD, a 2-year $4.9 million grant to develop a tool scientists can use to link information about drugs, diseases and genes.

17 Sep 2014

UCSD researchers launch phase 1 trial to assess novel monoclonal antibody for CLL patients

Researchers at the University of California, San Diego School of Medicine have launched a phase 1 human clinical trial to assess the safety and efficacy of a new monoclonal antibody for patients with chronic lymphocytic leukemia (CLL), the most common form of blood cancer in adults.

17 Sep 2014

Reproductive cell division has mechanical safeguard against chromosome sorting errors

Reproductive cell division has evolved a simple, mechanical solution to avoid chromosome sorting errors, researchers report in the Sept. 11 Science Express.

17 Sep 2014

New method helps reveal secret dance of proteins

Staying clear of diseases requires that the proteins in our cells cooperate with one another. But, it has been a well-guarded secret how tens of thousands of different proteins find the correct dancing partners as they degrade and build up the human body, brain and nervous system.

17 Sep 2014

Research findings could help explain how some people stave off dementia

The human brain is capable of a neural workaround that compensates for the buildup of beta-amyloid, a destructive protein associated with Alzheimer's disease, according to a new study led by researchers at the University of California, Berkeley.

17 Sep 2014

Neuroscientists discover key gene linked to origins of speech

Neuroscientists have found that a gene mutation that arose more than half a million years ago may be key to humans' unique ability to produce and understand speech.

16 Sep 2014

MSU researchers show how bacterial immune systems fight off viruses

When this week's print issue of the journal Science comes out, a collective cheer will go up from New Mexico, Montana and even the Netherlands, thanks to the type of collaborative effort that is more and more the norm in these connected times. Yes, the research was brilliant, and if we're lucky, it will produce innovations in biology, medicine, biotechnology and agriculture. It could save lives, and it happened because this scientist talked with that one, that one knew another one, and brilliant minds overcame geographic distance to advance human understanding.

16 Sep 2014

Leaky intestines may cripple bacteria-fighting immune cells in patients with CVID

Leaky intestines may cripple bacteria-fighting immune cells in patients with a rare hereditary disease, according to a study by researchers in Lausanne, Switzerland. The study, published in The Journal of Experimental Medicine, may explain why these patients suffer from recurrent bacterial infections.

16 Sep 2014

G Protein News and Research

Penn Medicine, Wistar Institute awarded NCI grants for four new melanoma research projects

Study suggests potential treatment for cardiovascular disease in people with apoE4 gene variant

Common type of hospital-associated infections can be prevented with vaccine

New approach to imaging metastatic tumors

UAB researchers discover novel mechanism involved in formation of memory, learning

Studies explore role of STXBP5 gene in development of cardiovascular disease

Scientists find 23 new genetic variants that increase risk for prostate cancer

Rosuvastatin promotes bone growth in mice with achondroplasia symptoms

Disrupting cancer regulator MYC: an interview with Professor Kim Janda

S. pneumoniae drug susceptibility tracked in Japan

Isis receives $4 million in milestone payment from Achaogen for initiation of plazomicin Phase 3 study

UMass Amherst doctoral student in chemistry receives USP's 2014-15 Global Fellowship Award

NIH awards grant to scientist to link drugs, genes and diseases

UCSD researchers launch phase 1 trial to assess novel monoclonal antibody for CLL patients

Reproductive cell division has mechanical safeguard against chromosome sorting errors

New method helps reveal secret dance of proteins

Research findings could help explain how some people stave off dementia

Neuroscientists discover key gene linked to origins of speech

MSU researchers show how bacterial immune systems fight off viruses

Leaky intestines may cripple bacteria-fighting immune cells in patients with CVID

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

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