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New AF267B drug reverses key cognitive deficits, pathology in Alzheimer's

A new drug that enhances the activity of a key brain cell receptor involved in Alzheimer's disease (AD) reverses learning and memory deficits in mice engineered to have pathological hallmarks of the disease.

13 Mar 2006

New genome-wide map of miRNA-MRNA interactions

Researchers at New York University's Center for Comparative Functional Genomics and the University of California, Berkeley have used computational analyses to predict a genome-wide map of microRNA (miRNA) targets in the animal model organism, Caenorhabditis elegans (C. elegans).

9 Mar 2006

Major biomarker candidates for Alzheimer's disease explored

Alzheimer's disease - specific biomarkers clearly are needed for the differential diagnosis of cognitive impairment in the elderly.

8 Mar 2006

Hydrogel scaffold materials used to create stable networks of blood vessels

Yale biomedical engineers have created an implantable system that can form and stabilize a functional network of fine blood vessels critical for supporting tissues in the body, according to a report in the Proceedings of the National Academy of Sciences.

1 Mar 2006

Researchers transplant insulin-producing neonatal porcine islet cells into monkeys

A team of researchers from the University of Alberta, the Yerkes National Primate Research Center of Emory University and the Emory Transplant Center has successfully transplanted insulin-producing neonatal porcine islet cells into monkeys, a procedure the researchers say represents a promising intermediate solution to the critical supply problem in clinical islet cell transplantation.

27 Feb 2006

PET and MR imaging reveals white matter degeneration in Huntington's

Using both brain function (PET) and anatomical structure (MR) imaging studies, Italian researchers - within the context of an Italian-British collaboration - discovered that degenerative and dysfunctional events occur in individuals many years before the onset of Huntington's disease - particularly in the brain's white matter - an area not previously considered primarily involved with the disease.

24 Feb 2006

Selective T cell stimulation could help improve treatment of autoimmune disease and cancer

The findings could also be significant for developing new ways to help patients with autoimmune diseases such as rheumatoid arthritis, multiple sclerosis, or juvenile diabetes.

23 Feb 2006

Scientists map brain area that may help find human brain stem cells

A study led by a Johns Hopkins neurosurgeon has provided the first comprehensive map of a part of the adult human brain containing astrocytes, cells known to produce growth factors critical to the regeneration of damaged neural tissue and that potentially serve as brain stem cells.

17 Feb 2006

Rett disease progression altered by changing expression of gene

Scientists from the Whitehead Institute for Biomedical Research, Brandeis University and Massachusetts Institute of Technology report in the journal Neuron that increasing levels of brain derived neurotrophic factor (BDNF) alleviates symptoms in a mouse model of the childhood disorder Rett Syndrome.

13 Feb 2006

Changes in the tissue environment of the breast that occur after pregnancy promote the metastasis of breast tumor cells

Changes in the tissue environment of the breast that occur after pregnancy promote the metastasis of breast tumor cells. The paper by McDaniel et al., "Remodeling of the mammary microenvironment following lactation promotes breast tumor cell metastasis.

12 Feb 2006

Viragen reports on Multiferon anti-viral studies

Viragen, Inc today reported on the progression of anti-viral studies using Multiferon (multi-subtype, natural human alpha interferon) being conducted by the U.S. Army Medical Research Institute of Infectious Diseases (USAMRIID).

7 Feb 2006

Cranberry proanthocyanidins inhibit growth of tumor cells

New data shows that proanthocyanidins, or PACs, found in cranberries inhibit the growth of lung tumors and colon and leukemia cells in vitro.

25 Jan 2006

New tool for genetic research

In an article appearing online today in the journal Nature Methods, researchers at the EPFL (Ecole Polytechnique Fidirale de Lausanne) unveil a powerful new tool that will facilitate genetic research and open up new avenues for the clinical treatment of genetic disease.

23 Jan 2006

Morphotek issued patent covering the use of chemical inhibitors of mismatch repair

Morphotek Inc. announced today the issuance of United States Patent 6,982,169 covering the use of chemical inhibitors to enhance evolution of target host cell genomes by reversibly regulating mismatch repair (MMR) in vivo.

23 Jan 2006

Novel compound stops brain cell degeneration in Alzheimer's disease

Drug discovery researchers at Northwestern University have developed a novel orally administered compound specifically targeted to suppress brain cell inflammation and neuron loss associated with Alzheimer's disease.

22 Jan 2006

Electrical microstimulation allows researchers to map the brain for the first time

Over the last two centuries electrical microstimulation has been often used to demonstrate causal links between neural activity and specific behaviors or cognitive functions. However, to understand the mechanisms by which electrical microstimulation can cause alternations in behaviors and cognitive functions it is imperative to characterize the cortical activity patterns that are elicited by stimulation locally around the electrode and in other functionally connected areas.

22 Dec 2005

A crucial role for TGF-beta signaling in congenital eye disorders

The lens in the developing eye acts as a TGF-beta signaling center that controls differentiation, survival and formation of multiple eye structures deriving from the neural crest.

15 Dec 2005

A colonization factor links Vibrio cholerae environmental survival and human infection

Opening a new door to an effective vaccine and therapy for a disease that strikes thousands annually, researchers at Dartmouth Medical School discovered that the bacteria that causes the intestinal disease Cholera spreads in the environment in much the same way it infects humans.

13 Dec 2005

Phenolic compounds in olive oil may explain cardiovascular health benefits associated with Mediterranean Diet

Phenolic compounds in olive oil, which have antioxidant, anti-inflammatory and anti-clotting properties, may explain cardiovascular health benefits associated with the so-called Mediterranean Diet, according to a new study in the Nov. 15, 2005, issue of the Journal of the American College of Cardiology.

13 Nov 2005

Sensors, a smart dose of medicine for cancer treatment

New sensor systems being developed will help treat cancer and improve the accuracy and reliability of existing radiation treatments. They should help improve patient care and outcomes. The results will go straight to commercialisation when finalised next year.

7 Nov 2005