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Cellular program could turn T cells into effective cancer killers

Cancer-fighting immune cells in patients with lung cancer whose tumors do not respond to immunotherapies appear to be running on a different "program" that makes them less effective than immune cells in patients whose cancers respond to these immune treatments, suggests a new study led by researchers at the Johns Hopkins Kimmel Cancer Center Bloomberg~Kimmel Institute for Cancer Immunotherapy.

9 Sep 2021

Restoring beneficial gut microbes to enhance the efficacy of cancer immunotherapy

The gut microbiome - the collection of bacteria, viruses, fungi, and other microorganisms that reside in our gastrointestinal tracts - can impact us in a variety of different ways, from our metabolism to our mood.

9 Sep 2021

Study: Nearly one in five patients with malignant pleural mesothelioma contracted COVID-19

Nearly one in five patients with malignant pleural mesothelioma (MPM) at a Barcelona hospital contracted COVID-19 during the pandemic.

8 Sep 2021

$New tool can rapidly quantify T cell fraction and predict immunotherapy response$

New tool can rapidly quantify T cell fraction and predict immunotherapy response

Scientists at UCL and the Francis Crick Institute, London, have developed a new tool, which can rapidly estimate the number of T cells (immune cells) in a cancerous tumor; with T cell abundance helping predict a patient's response to immunotherapy, researchers are hopeful this could enable more targeted and effective cancer therapies.

8 Sep 2021

AI can spot signs of lung cancer on CT scans a year earlier

An artificial intelligence (AI) program can spot signs of lung cancer on CT scans a year before they can be diagnosed with existing methods, according to research presented at the European Respiratory Society International Congress.

8 Sep 2021

COVID-19 vaccine antibodies inversely related to BMI in obese men, but not women

A new study discusses the role of obesity in COVID-19 and its role in antibody-mediated immune responses to the COVID-19 vaccine.

7 Sep 2021

Activated mast cell disorders potentially linked to SARS-CoV-2 immunity

An intriguing new study reports a year-long study in patients with cMCADs from all over France.

7 Sep 2021

Cancer immunotherapies could benefit older patients as much as younger people

A retrospective analysis of large datasets of biomarkers from tumors and healthy tissue by researchers at the Johns Hopkins Kimmel Cancer Center Convergence Institute suggests that older cancer patients could benefit as much as younger patients from cancer immunotherapies.

7 Sep 2021

Research reveals a previously unknown role for a key transcription regulator linked to cancer

CTCF is a transcription factor that has been a research target due to its role in regulating a critical oncogene called MYC.

7 Sep 2021

Deep learning provides a better estimate of breast cancer risk

Compared with commonly used clinical risk factors, a sophisticated type of artificial intelligence (AI) called deep learning does a better job distinguishing between the mammograms of women who will later develop breast cancer and those who will not, according to a new study in the journal Radiology.

7 Sep 2021

Novel assay helps identify factors that can convert normal cells into liver cancer cells

Researchers at the University of Helsinki could show for the first time that normal human fibroblast cells can be converted to specific cancer cells using only factors that are commonly detected in actual human patients.

7 Sep 2021

New insights could help unlock the mystery of how lung cancer arises in never smokers

A genomic analysis of lung cancer in people with no history of smoking has found that a majority of these tumors arise from the accumulation of mutations caused by natural processes in the body.

6 Sep 2021

Simple, non-invasive tool obviates unnecessary surgery in patients with colorectal cancer

A blood RNA test predicts whether residual tumour cells remain in early-stage colon cancer patients and obviates unnecessary surgery.

6 Sep 2021

Prognostic impact of common type of liver cancer depends on tumor size, research reveals

Researchers at the Department of Hepato-Biliary-Pancreatic Surgery, Osaka City University Graduate School of Medicine have shown that the prognostic impact of hepatocellular carcinoma (HCC), the most common type of liver cancer, is dependent on tumor size.

6 Sep 2021

Decreased COVID-19 vaccine efficacy amongst IBS patients receiving anti-TNFα drugs

In a paper recently uploaded to the preprint server medRxiv* by Edelman-Klapper et al., the efficacy of the mRNA vaccine is examined amongst IBD patients and compared with healthy volunteers, finding reduced efficacy amongst those receiving anti-TNFα medication.

6 Sep 2021

New type of algorithm simplifies comparisons between effects of electrical stimulation on the brain

For millions of people with epilepsy and movement disorders such as Parkinson's disease, electrical stimulation of the brain already is widening treatment possibilities. In the future, electrical stimulation may help people with psychiatric illness and direct brain injuries, such as stroke.

6 Sep 2021

Researchers develop the smallest CRISPR to date for genome editing

A compact and efficient CRISPR-Cas system, named CasMINI, could be broadly useful for cell-engineering and gene-therapy applications because it is easier to deliver into cells. The findings appear in a study publishing September 3 in the journal Molecular Cell.

4 Sep 2021

Practical solutions in shoulder arthroplasty for patients with glenoid bone loss

Today, at the American Academy of Orthopaedic Surgeons (AAOS) 2021 annual meeting, Hospital for Special Surgery (HSS) sports medicine surgeon David M. Dines, MD, participated in an instructional case lecture on practical solutions in shoulder arthroplasty for patients with substantial shoulder socket bone loss known as glenoid bone deficiency.

4 Sep 2021

Stanford researchers engineer an efficient, multi-purpose, mini CRISPR system

The common analogy for CRISPR gene editing is that it works like molecular scissors, cutting out select sections of DNA. Stanley Qi, assistant professor of bioengineering at Stanford University, likes that analogy, but he thinks it's time to reimagine CRISPR as a Swiss Army knife.

4 Sep 2021

Stem-like T cells within certain lymph nodes could be natural cancer fighters, study shows

In a new study by Yale Cancer Center, researchers show stem-like T cells within certain lymph nodes could be natural cancer fighters.

3 Sep 2021

Tumor News and Research

Cellular program could turn T cells into effective cancer killers

Restoring beneficial gut microbes to enhance the efficacy of cancer immunotherapy

Study: Nearly one in five patients with malignant pleural mesothelioma contracted COVID-19

New tool can rapidly quantify T cell fraction and predict immunotherapy response

AI can spot signs of lung cancer on CT scans a year earlier

COVID-19 vaccine antibodies inversely related to BMI in obese men, but not women

Activated mast cell disorders potentially linked to SARS-CoV-2 immunity

Cancer immunotherapies could benefit older patients as much as younger people

Research reveals a previously unknown role for a key transcription regulator linked to cancer

Deep learning provides a better estimate of breast cancer risk

Novel assay helps identify factors that can convert normal cells into liver cancer cells

New insights could help unlock the mystery of how lung cancer arises in never smokers

Simple, non-invasive tool obviates unnecessary surgery in patients with colorectal cancer

Prognostic impact of common type of liver cancer depends on tumor size, research reveals

Decreased COVID-19 vaccine efficacy amongst IBS patients receiving anti-TNFα drugs

New type of algorithm simplifies comparisons between effects of electrical stimulation on the brain

Researchers develop the smallest CRISPR to date for genome editing

Practical solutions in shoulder arthroplasty for patients with glenoid bone loss

Stanford researchers engineer an efficient, multi-purpose, mini CRISPR system

Stem-like T cells within certain lymph nodes could be natural cancer fighters, study shows

Industry Focus eBook - Cell & Gene Therapy (1st Edition) eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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