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Spike protein mutations in SARS-CoV-2 variants help resist antibody neutralization

Researchers based in Beijing and Shenzhen, China, report that they have identified mutations in the spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that may allow variant strains to avoid neutralization by monoclonal antibodies and convalescent blood plasma.

11 Mar 2021

N501Y mutation in SARS-CoV-2 responsible for increased viral transmission

Researchers at the University of Texas, USA, have confirmed the specific mutation in the B.1.1.7 variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), has allowed for it to be more transmissible than the ancestral strain. The N501Y substitution is one of 8 spike protein substitutions present in the UK variant and has also appeared convergently in the Brazil (P.1) and South Africa (B.1.351) variants.

11 Mar 2021

Structure and function of locked conformation of the SARS-CoV-2 spike protein identified

A new preprint research paper, posted to the bioRxiv* server, uncovered more information on the different structural conformations of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The findings suggest the spike protein turns into a locked state to stabilize the spike protein during virus egress.

11 Mar 2021

Delaying second dose of Pfizer-BioNTech SARS-CoV-2 vaccine may be feasible in some cases

Researchers in Spain have conducted the most extensive study to date investigating the effectiveness of vaccinating healthcare workers with a single dose of the Pfizer-BioNTech vaccine to protect against coronavirus disease 2019 (COVID-19).

11 Mar 2021

Study addresses glycosylation concerns in SARS-CoV-2 vaccine design

An international team of researchers has found that glycosylation patterns are conserved across the native spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent that causes coronavirus disease 2019 (COVID-19) – and the recombinant spike proteins made in laboratories for use in vaccines.

11 Mar 2021

Newly discovered cellular stress enzyme may be a target for neurodegenerative disease treatments

An enzyme called MARK2 has been identified as a key stress-response switch in cells in a study by researchers at Johns Hopkins Bloomberg School of Public Health.

11 Mar 2021

Researchers unveil new technique for observing metabolic processes in real time

Magnetic resonance imaging (MRI) is already widely used in medicine for diagnostic purposes. Hyperpolarized MRI is a more recent development and its research and application potential has yet to be fully explored.

11 Mar 2021

Texas Biomed receives DoD subcontracts to assess SARS-CoV-2 decontamination technologies

Texas Biomedical Research Institute received two Department of Defense's (DoD) Defense Health Agency subcontracts to assess the efficacy of surface coating and aerosolized decontamination technologies to combat SARS-CoV-2 and other respiratory pathogens on surfaces and in the air.

11 Mar 2021

Unbalanced progesterone may cause preterm or prolonged labor in some pregnant women

New research by the National Institutes of Health found that unbalanced progesterone signals may cause some pregnant women to experience preterm labor or prolonged labor.

11 Mar 2021

Early tracheotomy shortens ICU stay and lowers risk of ventilator-associated pneumonia

Surgically opening the windpipe, or trachea, within the first seven days of the start of mechanical ventilation decreases the time patients spend on ventilators, shortens their ICU stay and lowers their risk of ventilator-associated pneumonia, according to a systematic review published Thursday (March 11) in JAMA Otolaryngology-Head & Neck Surgery.

11 Mar 2021

Princeton researchers elucidate how hepatitis B virus establishes chronic infection

Researchers at Princeton have determined how five cellular proteins contribute to an essential step in the life cycle of hepatitis B virus (HBV).

11 Mar 2021

NCCN publishes new guidance for management of COVID-19 in cancer patients

The National Comprehensive Cancer Network--an alliance of leading cancer centers--has published new best practice recommendations for Management of COVID-19 Infection in Patients with Cancer.

11 Mar 2021

New biodegradable nanoprobes could help detect cancer more accurately

New Imperial-developed nanoprobes tested in zebrafish could help detect cancer more accurately and might aid diagnosis and therapy in the future.

11 Mar 2021

Henry Ford Cancer Institute launches new initiative to improve minority participation in clinical trials

Henry Ford Cancer Institute is launching the Participatory Action for Access to Clinical Trials (PAACT) project to dramatically improve the representation of the African American community and other minorities in cancer clinical trials.

11 Mar 2021

Jobs with greater risk for COVID-19 exposure have high number of Black or Hispanic workers

Black and Hispanic people experience a higher risk for COVID-19 and severe illness, influenced by factors such as discrimination, housing, and healthcare access and utilization.

11 Mar 2021

Researchers discover new protein that may play a key role in atherosclerosis

Atherosclerosis is the underlying condition that causes heart attacks and strokes. Researchers at Radboudumc in the Netherlands have discovered a protein that appears to play an important role in atherosclerosis.

11 Mar 2021

Studies reveal how kidney tumors' microenvironments change in response to immunotherapy

In the last two decades, immunotherapy has emerged as a leading treatment for advanced renal carcinoma cancer (more commonly known as kidney cancer).

11 Mar 2021

Study reveals how lung alveolus forms at cellular level

Researchers from Children's Hospital of Philadelphia have determined what happens at a cellular level as the lung alveolus forms and allows newborns to breathe air.

11 Mar 2021

VEXAS syndrome in men is more common than previously thought

A rare disease first identified in 2020 is much more common than first thought, say researchers at the University of Leeds investigating its origins.

11 Mar 2021

Delays in treatment at the hospital may have severe consequences on stroke recovery

For every 10-minute delay between arrival at the emergency room (ER) and starting stroke treatment, patients with severe strokes may lose eight weeks of healthy life, according to preliminary research to be presented at the American Stroke Association's International Stroke Conference 2021.

11 Mar 2021

Research News and Research

Spike protein mutations in SARS-CoV-2 variants help resist antibody neutralization

N501Y mutation in SARS-CoV-2 responsible for increased viral transmission

Structure and function of locked conformation of the SARS-CoV-2 spike protein identified

Delaying second dose of Pfizer-BioNTech SARS-CoV-2 vaccine may be feasible in some cases

Study addresses glycosylation concerns in SARS-CoV-2 vaccine design

Newly discovered cellular stress enzyme may be a target for neurodegenerative disease treatments

Researchers unveil new technique for observing metabolic processes in real time

Texas Biomed receives DoD subcontracts to assess SARS-CoV-2 decontamination technologies

Unbalanced progesterone may cause preterm or prolonged labor in some pregnant women

Early tracheotomy shortens ICU stay and lowers risk of ventilator-associated pneumonia

Princeton researchers elucidate how hepatitis B virus establishes chronic infection

NCCN publishes new guidance for management of COVID-19 in cancer patients

New biodegradable nanoprobes could help detect cancer more accurately

Henry Ford Cancer Institute launches new initiative to improve minority participation in clinical trials

Jobs with greater risk for COVID-19 exposure have high number of Black or Hispanic workers

Researchers discover new protein that may play a key role in atherosclerosis

Studies reveal how kidney tumors' microenvironments change in response to immunotherapy

Study reveals how lung alveolus forms at cellular level

VEXAS syndrome in men is more common than previously thought

Delays in treatment at the hospital may have severe consequences on stroke recovery

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