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CTI BioPharma announces Phase III results of PIXUVRI combined with rituximab in aggressive B-cell NHL patients

CTI BioPharma Corp. and Servier today announced that the pivotal Phase III study evaluating PIXUVRI® combined with rituximab in comparison to gemcitabine combined with rituximab in patients with aggressive B-cell non-Hodgkin lymphoma did not meet its primary endpoint of improvement of progression-free survival

9 Jul 2018

Researchers show how mutant CALR protein triggers cancer

Researchers at Juntendo University report in the journal Leukemia how mutants of the protein calreticulin lead to molecular mechanisms triggering myeloproliferative neoplasms, which can cause cancer. The findings may lead to the development of novel therapies for certain types of blood cancer.

28 Jun 2018

New guidelines recommend newborns with Down’s syndrome to receive leukemia test

New genetic testing has been developed at the University of Oxford to detect early signs of a potentially fatal condition that can also develop into full blown leukaemia in children with Down’s syndrome.

21 Jun 2018

Immunosuppressed patients with sepsis more likely to die if treated in hospitals caring for few such patients

Immunosuppressed patients with sepsis appear more likely to die if they are treated in a hospital caring for a relatively small number of these patients, according to new research published online in the Annals of the American Thoracic Society.

6 Jun 2018

Phase I trial shows safety of investigational drug in treating chronic lymphocytic leukemia

Reporting results from a first-in-human phase I clinical trial, researchers at University of California San Diego School of Medicine have found that treatment with cirmtuzumab, an experimental monoclonal antibody-based drug, measurably inhibited the "stemness" of chronic leukemia cancer cells - their ability to self-renew and resist terminal differentiation and senescence.

1 Jun 2018

Study: Immunosuppressed patients with sepsis more likely to die during hospitalization

1 Jun 2018

Mesoblast and Cartherics form partnership to develop 'off-the-shelf' CAR-T therapies for solid cancers

Mesoblast Limited today announced that it has entered into a partnership with Cartherics Pty Ltd to develop allogeneic ‘off-the-shelf’ CAR-T cells armed with multiple targeting receptors for use in solid cancers. Off the shelf CAR-T therapies have the potential to reduce costs dramatically and open up this very effective treatment to millions of cancer patients across the world.

31 May 2018

UAB-led clinical trial intends to find innovative treatment for multiple myeloma patients

Multiple myeloma is the second most common type of blood cancer in the United States, impacting more than 25,000 people each year and disproportionatly affecting African-American men.

15 May 2018

Researchers show how Spred1 molecule protects HSC homeostasis under diet-induced stress

Researchers at Kanazawa University report in Cell Stem Cell how the Spred1 molecule is involved in hematopoietic stem cell self-renewal. Experiments with mouse models show that under normal conditions, Spred1 acts as a negative regulator, while under diet-induced stress, it protects hematopoietic homeostasis.

28 Apr 2018

Researchers identify protein crucial for leukemia's aggressiveness

Researchers have identified a protein critical for the aggressiveness of T-cell leukemia, a subtype of leukemia that afflicts children and adults.

27 Apr 2018

Study finds myeloma precursor disease in 9/11 firefighters

A study in today's issue of JAMA Oncology reports that New York City firefighters exposed to the 9/11 World Trade Center disaster site face an increased risk for developing myeloma precursor disease (MGUS), which can lead to the blood cancer multiple myeloma.

26 Apr 2018

Scripps Florida researchers awarded $2.875 million to destroy common form of leukemia

Christoph Rader, PhD, associate professor at the Florida campus of The Scripps Research Institute, has been awarded a $2.875 million, five-year grant from the National Cancer Institute to develop unique antibody-drug conjugates engineered to eradicate one of the most common forms of leukemia, chronic lymphocytic leukemia

10 Apr 2018

Study finds link between industry payments and prescription practices for two cancer types

Physicians who received payment from pharmaceutical companies for meals, talks and travel were more likely to prescribe those companies' drugs for two cancer types, a University of North Carolina Lineberger Comprehensive Cancer Center-led study has found.

9 Apr 2018

Scientists identify key genetic events responsible for initiating childhood leukemia

The key genetic events responsible for initiating the early stages of a type of childhood leukemia have been identified by scientists at The Institute of Cancer Research, London. Insights into the ‘founder’ genetic mutation for this type of leukemia, present in all the cancer cells, could be used in the development of new targeted drugs.

6 Apr 2018

Researchers discover a new molecular cause for aggressive leukemia in children

Around 600 children under the age of 15 are diagnosed with leukemia each year in Germany. The effects are especially dramatic if this severe illness develops at birth or shortly afterwards.

4 Apr 2018

Researchers prove link between common childhood cancer and inflammation

The team of María Domínguez, researcher for the Neuroscience Institute, joint venture of the Miguel Hernández University in Elche and the Spanish National Research Council, has managed to prove for the first time that an important factor in the development of acute pediatric lymphoblastic leukemia is inflammation.

22 Mar 2018

Study finds prevalence of cognitive decline among elderly patients with blood-related cancers

A sizable percentage of elderly patients with blood-related cancers such as leukemia and multiple myeloma are apt to show signs of diminished cognitive functioning, a decline that may impact their survival, a new study by investigators at Dana-Farber Cancer Institute and Brigham and Women's Hospital indicates.

6 Mar 2018

Blood Cancer News and Research

CTI BioPharma announces Phase III results of PIXUVRI combined with rituximab in aggressive B-cell NHL patients

Researchers show how mutant CALR protein triggers cancer

New guidelines recommend newborns with Down’s syndrome to receive leukemia test

Immunosuppressed patients with sepsis more likely to die if treated in hospitals caring for few such patients

Phase I trial shows safety of investigational drug in treating chronic lymphocytic leukemia

Study: Immunosuppressed patients with sepsis more likely to die during hospitalization

Mesoblast and Cartherics form partnership to develop 'off-the-shelf' CAR-T therapies for solid cancers

UAB-led clinical trial intends to find innovative treatment for multiple myeloma patients

Researchers show how Spred1 molecule protects HSC homeostasis under diet-induced stress

Researchers identify protein crucial for leukemia's aggressiveness

Study finds myeloma precursor disease in 9/11 firefighters

Scripps Florida researchers awarded $2.875 million to destroy common form of leukemia

Study finds link between industry payments and prescription practices for two cancer types

Scientists identify key genetic events responsible for initiating childhood leukemia

Researchers discover a new molecular cause for aggressive leukemia in children

Researchers prove link between common childhood cancer and inflammation

Study finds prevalence of cognitive decline among elderly patients with blood-related cancers

CAR-T therapy saves life of cancer researcher

Modular gene enhancers may be suitable target in treatment of blood cancer

Patients with monoclonal gammopathy at risk of developing cancer even after 30 years

Industry Focus eBook - Cell & Gene Therapy (1st Edition) eBook

How Omics Technologies Are Transforming Biological Research and Drug Discovery

How microplastics and bacteria interact to drive antibiotic resistance

Single-cell proteomics: Revealing proteome diversity from cellular heterogeneity to non-canonical biology

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