Malignant News and Research

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Early lung cancer detection with a machine learning model based on imaging, clinical, and DNA methylation biomarkers

Researchers discuss the development and validation of a combined model for the early diagnosis of lung cancer.

15 Aug 2023

New diagnostic tool could revolutionize early bladder cancer detection

Bladder cancer has a five-year survival rate of over 80% when detected early, but this rate declines significantly as the disease progresses to advanced stages.

14 Aug 2023

Diverse gut microbiome may help children survive stem cell transplant

Researchers in Italy have shown for the first time that among children who have undergone a donor stem cell transplant, the presence of diverse species of micro-organisms in the intestinal tract before the transplant resulted in significantly better overall patient survival and fewer complications.

10 Aug 2023

Study examines shared genetic etiology of chronic diseases and links leukocyte telomere length to heart failure risk

Researchers performed a prospective cohort study to investigate the shared genetic etiology between chronic diseases.

10 Aug 2023

GABA transfer between skin cells promotes melanoma initiation

The transfer of a neurotransmitter from one type of skin cell to another (melanocytes to keratinocytes) altered electrical activity and promoted melanoma initiation in preclinical models, according to results published in Cancer Discovery, a journal of the American Association for Cancer Research.

9 Aug 2023

CT imaging reveals that COVID-19 vaccination may protect against severe lung pathology

Researchers determine how COVID-19 vaccination influences lung-sequelae-related pathology and the manifestation of severe infection.

9 Aug 2023

Researchers develop new method to find mutations in pediatric brain tumors

Researchers at Uppsala university have developed a new method to find mutations in brain tumors in children.

7 Aug 2023

NCI funds study to investigate the underlying cellular mechanisms that drive ER+ breast cancer

The National Cancer Institute (NCI) has awarded a 5-year, $2.7 million grant to researchers at Sanford Burnham Prebys to investigate and elucidate the underlying cellular mechanisms that drive the most common form of breast cancer.

7 Aug 2023

Adenoid cystic carcinoma of the head and neck: A review of treatment strategies

A new editorial paper was published in Oncoscience (Volume 10) on June 28, 2023, entitled, "Adenoid cystic carcinoma of the head and neck – treatment strategies of a highly malignant tumor with variable localizations."

6 Aug 2023

New PCNA inhibitor AOH1996 shows selective cancer cell killings and tumor suppression potential

Study described a small molecule inhibitor of proliferating cell nuclear antigen (PCNA) that selectively kills cancer cells.

4 Aug 2023

Gene expression ratio linked to prognosis in solid tumors

A Ludwig Cancer Research study has identified a pair of genes whose expression by a type of immune cell within tumors is predictive of outcomes for cancer patients and is linked to a vast network of gene expression programs, engaged by multiple cell types in the tumor microenvironment, that control human cancers.

3 Aug 2023

Virtual reality-based exercises found to reduce depression and anxiety among individuals treated with hemodialysis

Researchers determined the association between regular physical exercise based on virtual reality (VR) and the development of depression.

3 Aug 2023

Rockefeller researchers reveal the mechanisms behind malignant turn of events in cancer

Early on, every stem cell faces a fateful choice. During skin development, for instance, the embryonic epidermis begins as a single layer of epidermal progenitor cells.

31 Jul 2023

Reinforcement learning improves performance of AI-based skin cancer diagnosis

Artificial intelligence (AI) is already being used to diagnose skin cancer, but it cannot (yet) keep pace with the complex decision-making of doctors in practice.

28 Jul 2023

New gene editing approach could revolutionize the treatment of blood disorders

In a step forward in the development of genetic medicines, researchers at Children's Hospital of Philadelphia (CHOP) and the Perelman School of Medicine at the University of Pennsylvania have developed a proof-of-concept model for delivering gene editing tools to treat blood disorders, allowing for the modification of diseased blood cells directly within the body.

27 Jul 2023

Researchers discover potential new treatment for rhabdomyosarcoma

Researchers from the Leibniz Institute on Aging in Jena and the Brandenburg University of Technology Cottbus-Senftenberg have discovered a novel treatment approach for soft tissue tumors, which are frequently occurring in children and are often malignant.

26 Jul 2023

A novel pharmacology modeling approach to monitor acute lymphoblastic leukemia treatment

This research paper published in Scientific Reports developed pharmacokinetic (PK) pharmacodynamic (PD) models of maintenance therapy for childhood acute lymphoblastic leukemia (ALL).

26 Jul 2023

Research reveals therapeutic potential of novel compound in inhibiting oncogene translation

Cutting-edge research at the Luxembourg Institute of Health reveals the ground-breaking therapeutic potential of the compound FL3 in inhibiting oncogene translation and rewiring cancer cell metabolism, opening up new therapeutic opportunities for leukemia patients.

24 Jul 2023

Six new Damon Runyon Clinical Investigators announced for 2023

The Damon Runyon Cancer Research Foundation has named six new Damon Runyon Clinical Investigators.

20 Jul 2023

Routine next-generation sequencing can identify BRAF mutations in synovial sarcoma

A new case report was published in Oncotarget's Volume 14 on July 7, 2023, entitled, "Intrathoracic synovial sarcoma with BRAF V600E mutation."

18 Jul 2023