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New study elucidates osteoblast production during bone regeneration

How osteoblasts are supplied during bone regeneration has been controversial among bone researchers. According to Atsushi Kawakami, an Associate Professor who specializes in tissue regeneration and led the study, scientists disagree on how these cells are made.

3 Nov 2017

Stem cells do not participate directly in cartilage regeneration but serve to ‘animate’ the process

Stem cell therapy has great potential for curing cartilage damage. However, it has remained unclear whether stem cells are responsible for regeneration or whether they trigger the process.

31 Oct 2017

Discovery may provide insight into how Zika virus gets transmitted from mother to fetus

Researchers at the University of California San Diego School of Medicine, with colleagues in Brazil, report that the Zika virus is transmitted from mother to fetus by infected cells that, ironically, will later develop into the brain's first and primary form of defense against invasive pathogens.

27 Oct 2017

Single infusion of wildtype HSPCs halts cellular damage caused by neuromuscular disorder in mice

Researchers at University of California San Diego School of Medicine report that a single infusion of wildtype hematopoietic stem and progenitor cells (HSPCs) into a mouse model of Friedreich's ataxia (FA) measurably halted cellular damage caused by the degenerative disease.

25 Oct 2017

Stem cell researchers make advance toward long-lasting blood vessel repair

Stem cell researchers at Emory University School of Medicine have made an advance toward having a long-lasting "repair caulk" for blood vessels. The research could form the basis of a treatment for peripheral artery disease, derived from a patient's own cells. Their results were recently published in the journal Circulation.

24 Oct 2017

CUMC researchers discover ‘cell of origin’ for esophageal cancer

Columbia University Medical Center researchers have identified cells in the upper digestive tract that can give rise to Barrett's esophagus, a precursor to esophageal cancer. The discovery of this "cell of origin" promises to accelerate the development of more precise screening tools and therapies for Barrett's esophagus and esophageal adenocarcinoma, the fastest growing form of cancer in the U.S.

11 Oct 2017

New cell therapy restores movement in people with paralyzing spinal cord injuries

Four of six people with paralyzing spinal cord injuries who were treated with a new cell therapy have recovered two or more motor levels on at least one side, new study results show.

6 Oct 2017

CRISPR-Gold corrects gene mutations in mice with Duchenne muscular dystrophy

Scientists at the University of California, Berkeley, have engineered a new way to deliver CRISPR-Cas9 gene-editing technology inside cells and have demonstrated in mice that the technology can repair the mutation that causes Duchenne muscular dystrophy, a severe muscle-wasting disease.

4 Oct 2017

DuraClone RE antibody panels improve detection of rare, abnormal events in blood disorders

Beckman Coulter Life Sciences has taken the detection of rare, abnormal events in blood disorders forward, with intro of antibody panels.

From Beckman Coulter Life Sciences - Flow Cytometry 28 Sep 2017

UAB researchers detail underlying mechanism leading to age-associated osteoporosis

A major health problem in older people is age-associated osteoporosis -- the thinning of bone and the loss of bone density that increases the risk of fractures. Often this is accompanied by an increase in fat cells in the bone marrow.

22 Sep 2017

Detailed understanding of ‘one of the most complex organs’ could provide new ways to treat lung disorders

Details of lung cell molecular pathways that promote or inhibit tissue regeneration were reported by researchers from the Perelmen School of Medicine at the University of Pennsylvania in Cell this week. Their aim is to find new ways to treat lung disorders.

7 Sep 2017

Scientist receives NIH grant to investigate tumor microenvironment from relatively new context

Cancer metastasis – the spread of disease from the original site to a distant organ – remains a major challenge in treating cancer and a main cause of morbidity and mortality.

6 Sep 2017

Research may lead to first-ever pharmacological treatment for rare genetic bone disease

Scientists at Children's Hospital of Philadelphia report that a drug candidate that blocks abnormal protein signals may lead to the first pharmacologic treatment for hereditary multiple exostoses (HME), a rare pediatric genetic disease.

29 Aug 2017

Targeting bone marrow protein could be effective way to improve stem cell transplants

Bone marrow contains hematopoetic stem cells, the precursors to every blood cell type. These cells spring into action following bone marrow transplants, bone marrow injury and during systemic infection, creating new blood cells, including immune cells, in a process known as hematopoiesis.

28 Aug 2017

Study provides new insight into development of immune cells

In contrast to what has been previously believed, development of blood stem cells to mast cells, a type of specialized immune cell, does not depend on a growth factor called stem cell factor.

10 Aug 2017

Gene-therapy administered through skin transplants could enable treatment of many diseases

A research team based at the University of Chicago has overcome challenges that have limited gene therapy and demonstrated how their novel approach with skin transplantation could enable a wide range of gene-based therapies to treat many human diseases.

3 Aug 2017

HIV hides in more types of bone marrow cells than previously thought, research shows

Every day, 17 million HIV-infected people around the world swallow pills that keep the virus inside them at bay.

1 Aug 2017

Researchers compare bone-healing effects of three low-dose growth factors

Researchers compared the effects of three bone growth factors to bone morphogenetic protein 2 (BMP2) -- the most commonly used agent for repair of large bone defects, which is not without risks at the doses required--and showed significant bone-healing effects including the formation of new blood vessels at low doses relative to BMP2.

28 Jul 2017

Scientists find single protein that controls genes essential for spermatogenesis

Scientists have found a single protein--Ptbp2--controls a network of over 200 genes central to how developing sperm move and communicate. The protein works by regulating how RNA is processed during each stage of sperm development.

10 Jul 2017

Ubiquitous human herpesvirus 6 may play key role in brain diseases like multiple sclerosis

The ubiquitous human herpesvirus 6 (HHV-6) may play a critical role in impeding the brain's ability to repair itself in diseases like multiple sclerosis.