Biochemistry News and Research

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Novel agents found to inhibit growth of estrogen-dependent breast cancer cells

Researchers have discovered a new family of agents that inhibit the growth of estrogen-dependent breast cancer cells. The finding, described at a meeting of the Endocrine Society, has opened an avenue of research into new drugs to combat estrogen-dependent breast cancers.

16 Jun 2008

Smad proteins regulate microRNA processing

Researchers at Tufts University School of Medicine and Tufts Medical Center have found that Smad proteins regulate microRNA (miRNA) processing.

11 Jun 2008

Synthetic molecules developed by Hebrew University researchers hold promise for new family of anti-cancer drugs

Synthetic molecules designed by two Hebrew University of Jerusalem researchers have succeeded in reducing and even eliminating the growth of human malignant tissues in mice, while having no toxic effects on normal tissue.

4 Jun 2008

RNA toxicity contributes to neurodegenerative disease

Expanding on prior research performed at the University of Pennsylvania, Penn biologists have determined that faulty RNA, the blueprint that creates mutated, toxic proteins, contributes to a family of neurodegenerative disorders in humans.

27 May 2008

New cheaper method for mapping disease genes

Scientists at the Swedish medical university Karolinska Institutet have developed a new DNA-sequencing method that is much cheaper than those currently in use in laboratories. They hope that this new method will make it possible to map disease genes in large patient groups, which in turn can mean quicker breakthroughs for new treatments for a wide variety of diseases.

26 May 2008

An alternative strategy for HIV vaccine research

Today, Advanced BioScience Laboratories, Inc. (ABL) and the University of Massachusetts Medical School (UMMS) report that their unique HIV vaccine formulation was effective in eliciting strong and balanced immune responses in healthy human volunteers.

22 May 2008

Scientists reveal the genetic determinants of fat storage in cells

New research by the Gladstone Institutes of Cardiovascular Disease (GICD) and the University of California, San Francisco (UCSF), has revealed the genetic determinants of fat storage in cells, which may lead to a new understanding of and potential treatments for obesity, diabetes, and heart disease. While scientists have long understood that lipid droplets contribute to fat build up in cells, the genes involved in droplet biology have been a focus of extensive research.

21 May 2008

Boost for cancer research in Leicestershire

A new approach to pain relief, investigation of a gene that triggers colorectal cancer and the prevention, early diagnosis and treatment of ovarian cancer are three research projects at the University of Leicester, which are to benefit from funding from the Leicestershire and Rutland charity Hope Against Cancer.

21 May 2008

VCU research team awarded NIH grant to study asthma, allergic disease

A team of Virginia Commonwealth University researchers has received a National Institute of Allergy and Infectious Diseases grant totaling nearly $7.3 million for a Cooperative Research Center to study various aspects of asthma and allergic disease.

20 May 2008

Structure of receptor for hot chili pepper and pain revealed

You can now not only feel the spicy kick of a jalapeno pepper, you can also see it in full 3D, thanks to researchers at Baylor College of Medicine in Houston.

19 May 2008

Researchers discover 'reservoir' that allows HIV to remain infectious despite treatment

Researchers at Brigham Young University and the Johns Hopkins School of Medicine have discovered a human cell "reservoir," called follicular dendritic cells, that allows HIV to stay in an infectious state and not respond to antiretroviral drugs, the Deseret Morning News reports.

19 May 2008

Plants deliver: biofuels, medicines, bioplastics, flavours, pigments...

The need for a renewable and affordable source of carbon that can sustain future economic development without negatively impacting the environment is now widely recognised. It is also apparent that the increasingly high demand for fossil carbon will eventually deplete existing stocks.

12 May 2008

Model shows how mutation tips biochemistry to cause Alzheimer's

Your fate can be determined by tiny events. Imagine you live in the city and you walk everywhere to get exercise - you are healthy and not afraid of getting mugged. You almost never eat breakfast so you don't stop at the donut shop on the way to work, until one day the manager replaces the girl at the counter with her pretty red-haired younger sister. This seemingly unimportant change in your world is just enough to overcome your ability to resist high-fat temptation. A million donuts later, your cholesterol level surges and then your heart gives out. Curse you, little red-haired girl!

12 May 2008

Blogging to bust cancer myths

The misinformation and confusion that often hovers around health and science stories will soon be dispelled by top science bloggers at Cancer Research UK.

9 May 2008

Scientists identify key roadblock to gene expression

A team of scientists has provided, for the first time, a detailed map of how the building blocks of chromosomes, the cellular structures that contain genes, are organized in the fruit fly Drosophila melanogaster. The work identifies a critical stop sign for transcription, the first step in gene expression, and has implications for understanding how the AIDS virus regulates its genes. The findings will be published in the 15 May 2008 issue of the journal Nature

8 May 2008

Nanoworms developed to target tumors

Scientists at UC San Diego, UC Santa Barbara and MIT have developed nanometer-sized "nanoworms" that can cruise through the bloodstream without significant interference from the body's immune defense system and-like tiny anti-cancer missiles-home in on tumors.

7 May 2008

New chemicals shield 'genome guardian'

Cancer Research UK scientists have discovered a potent group of chemicals that protect p53 - a major anti-tumour gene - from destruction, a study published in Cancer Cell* today (Monday) reveals.

6 May 2008

Discovery of tenovins could lead to cancer cure

Scientists in Scotland have discovered a group of chemicals which protect one of the body's most important anti-cancer genes from destruction.

6 May 2008

Study identifies new mechanism linking activation of key heart enzyme and oxidative stress

A study, led by University of Iowa researchers, reveals a new dimension for a key heart enzyme and sheds light on an important biological pathway involved in cell death in heart disease.

1 May 2008

Scientists discover the double life of proteins

Scientists at The Australian National University are a step closer to understanding the rare Hartnup disorder after discovering a surprising link between blood pressure regulation and nutrition that could also help to shed light on intestinal and kidney function.

30 Apr 2008