Genomic News and Research

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Researchers explore molecular mechanisms through which lead exposure may affect neural stem cells

Researchers have identified a potential molecular mechanism through which lead, a pervasive environmental toxin, may harm neural stem cells and neurodevelopment in children.

26 Aug 2016

Non-coding RNAs play key role in maintaining proper balance between fighting infection and inflammation

Special RNA molecules called long non-coding RNAs (lncRNAs) are key controllers for maintaining immune health when fighting infection or preventing inflammatory disorders, according to research led by Jorge Henao-Mejia, MD, PhD, an assistant professor of Pathology and Laboratory Medicine in the Perelman School of Medicine at the University of Pennsylvania.

25 Aug 2016

Preimplantation genetic screening using next generation sequencing: an interview with Dr Luis Alcaraz

PGS, Preimplantation Genetic Screening, is a genetic test that analyses biopsied cells from embryos produced by in vitro fertilization (IVF) techniques. PGS determines whether the embryos are chromosomally normal (euploid) or not (aneuploid), thus giving the chance to transfer chromosomally normal embryos that are more apt to successfully implant and develop into a pregnancy.

24 Aug 2016

VUMC receives $11 million renewal grant to advance pulmonary fibrosis research

Vanderbilt University Medical Center has received an $11 million program project renewal grant from the National Heart, Lung and Blood Institute to study the genetics and underlying biological mechanisms that lead to idiopathic pulmonary fibrosis (IPF).

23 Aug 2016

NIH researchers discover rare, lethal inflammatory disease that affects young children

National Institutes of Health researchers have discovered a rare and sometimes lethal inflammatory disease - otulipenia - that primarily affects young children. They have also identified anti-inflammatory treatments that ease some of the patients' symptoms: fever, skin rashes, diarrhea, joint pain and overall failure to grow or thrive.

23 Aug 2016

Low selenium levels linked to liver cancer risk? An interview with Dr David Hughes

Food provides us with a variety of substances we need to maintain life. These substances are essential nutrients and are classified as macronutrients (water, protein, fats, and carbohydrates) and micronutrients (vitamins and minerals).

22 Aug 2016

Study highlights racial/ethnic disparities in genomic sequencing

As scientists learn more about which genetic mutations are driving different types of cancer, they're targeting treatments to small numbers of patients with the potential for big payoffs in improved outcomes.

19 Aug 2016

New NIST Standard Reference Material helps ensure accurate measurements of HER2 breast cancer gene

A new measurement standard developed by the National Institute of Standards of Technology has been used successfully by the Frederick National Laboratory for Cancer Research to check the performance of next-generation DNA-sequencing technologies for evaluating gene variations associated with an increased risk of breast cancer.

18 Aug 2016

New research article reveals global patterns of genetic variation

Published in today's edition of Nature, the research led by Dr Monkol Lek of the University of Sydney and Dr Daniel MacArthur of The Broad Institute of MIT and Harvard Universities reveals patterns of genetic variation worldwide by sequencing the exomes of 60,706 individuals with diverse geographic ancestries, including European, African, South Asian, East Asian and Latino populations.

18 Aug 2016

Schizophrenia vulnerability emerged after divergence of modern humans from Neanderthals

Schizophrenia poses an evolutionary enigma. The disorder has existed throughout recorded human history and persists despite its severe effects on thought and behavior, and its reduced rates of producing offspring.

17 Aug 2016

Newfound role for PARP proteins could lead to therapeutic opportunities for cancer

Using technology they developed, UT Southwestern Medical Center researchers have identified a previously unknown role of a certain class of proteins: as regulators of gene activity and RNA processing.

16 Aug 2016

New study uncovers how chromosomal changes impact tumor formation and growth

As with most cancers, triple-negative breast cancer (TNBC) cells have abnormal amounts of chromosomes or DNA copy number aberrations (CNAs) in their genomes.

16 Aug 2016

Opioid naive individuals at low risk of developing persistent opioid use after surgery, research shows

Researchers from the University Health Network's Department of Anesthesia and Pain Management and the Institute for Clinical Evaluative Sciences have determined that patients who have not had an opioid prescription within a year prior to their procedure are at low risk of developing persistent opioid use after major surgery.

11 Aug 2016

Analysis of biopsies during early treatment predicts patient’s response to melanoma immunotherapy

Immune response measured in tumor biopsies during the course of early treatment predicts which melanoma patients will benefit from specific immune checkpoint blockade drugs, researchers at The University of Texas MD Anderson Cancer Center report in the journal Cancer Discovery.

11 Aug 2016

Pancreatic cancer cells find alternative source of nutrition to avoid starvation

Pancreatic cancer cells avert starvation in dense tumors by ordering nearby support cells to supply them with an alternative source of nutrition.

11 Aug 2016

Novel computational analysis of prostate cancer suggests potential targets for therapy

Cancer researchers have applied a comprehensive set of analytical tools to lethal cases of metastatic prostate cancer, yielding a detailed map of the complex networks of interactions among genes and proteins that enable prostate cancer cells to proliferate and evade treatment.

11 Aug 2016

Genomic News and Research

Researchers explore molecular mechanisms through which lead exposure may affect neural stem cells

Non-coding RNAs play key role in maintaining proper balance between fighting infection and inflammation

Preimplantation genetic screening using next generation sequencing: an interview with Dr Luis Alcaraz

VUMC receives $11 million renewal grant to advance pulmonary fibrosis research

NIH researchers discover rare, lethal inflammatory disease that affects young children

Low selenium levels linked to liver cancer risk? An interview with Dr David Hughes

Study highlights racial/ethnic disparities in genomic sequencing

New NIST Standard Reference Material helps ensure accurate measurements of HER2 breast cancer gene

New research article reveals global patterns of genetic variation

Schizophrenia vulnerability emerged after divergence of modern humans from Neanderthals

Newfound role for PARP proteins could lead to therapeutic opportunities for cancer

New study uncovers how chromosomal changes impact tumor formation and growth

Opioid naive individuals at low risk of developing persistent opioid use after surgery, research shows

Analysis of biopsies during early treatment predicts patient’s response to melanoma immunotherapy

Pancreatic cancer cells find alternative source of nutrition to avoid starvation

Novel computational analysis of prostate cancer suggests potential targets for therapy

Experts propose new clinical guidelines for diagnosing FASD

Researchers develop computational algorithm to analyze big genomic data for different cancers

Experts develop new genomic testing method for pulmonary hypertension caused by genetic mutation

UTA researcher to design computing tools to analyze large, complex patient data

The art of CRISPR: The power and promise of gene editing eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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