Preclinical News and Research

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Potential drug target to treat depression and other mood disorders may lie in GABA neurons

A new drug target to treat depression and other mood disorders may lie in a group of GABA neurons (gamma-aminobutyric acid -the neurotransmitters which inhibit other cells) shown to contribute to symptoms like social withdrawal and increased anxiety, Penn Medicine researchers report in a new study in the Journal of Neuroscience.

30 Aug 2013

Albumin-bound paclitaxel has favorable risk–benefit profile in NSCLC

Albumin-bound paclitaxel plus carboplatin is an effective and well-tolerated first-line treatment in patients with advanced non-small-cell lung cancer, irrespective of histology, study results show.

29 Aug 2013

Future of biomedical innovation depends on new trend for all players to work together for common goal

It's a long, expensive, risky road to turn a scientific breakthrough into a treatment that can help patients. Fewer organizations are trying to tackle the challenges alone, says a new paper from MIT researchers published August 28 in the journal Science Translational Medicine.

29 Aug 2013

Alzheimer’s drug trial: an interview with Geoffrey Kempler, Chairman & CEO Prana Biotechnology

Approval for the IMAGINE trial was granted by the Austin Health Research Ethics Committee in November 2011, with the first patients dosed in March the following year. However, well before the trial was approved, PBT2 had already shown promise in significantly changing Abeta levels in spinal fluid while improving cognition in a previous 12-week trial conducted in 2006.

28 Aug 2013

Institut Curie's Emmanuel Barillot receives Agilent Thought Leader Award

Agilent Technologies Inc. today announced that Dr. Emmanuel Barillot, director of Bioinformatics and Systems IT at the Institut Curie in Paris, has received an Agilent Thought Leader Award in recognition of his pioneering development of user-friendly, Web-based bioinformatics tools for systems toxicology.

28 Aug 2013

CST introduces HER3 antibody for studying HER2-mediated breast, lung and ovarian tumors

Cell Signaling Technology, Inc. of Danvers, MA, announced today that it has introduced a highly specific HER3 rabbit monoclonal antibody (mAb), an important addition for researchers studying HER2-mediated breast, lung and ovarian tumors.

From Cell Signaling Technology 28 Aug 2013

BiondVax: Priming with universal flu vaccine makes conventional bird flu vaccine effective against pandemic strains

BiondVax announced today that priming with universal flu vaccine before boosting with a conventional bird flu H5N1 vaccine (containing a single strain from Clade 1) resulted in mice exhibiting a significantly higher level of immunity to the strain contained in the conventional bird flu vaccine and in addition, broadened immunity to other H5N1 flu strains (from Clade 2).

27 Aug 2013

Mount Sinai scientists receive NIH grant to study clinical benefit of IGF-1 in children with PMS

Scientists at the Seaver Autism Center at the Icahn School of Medicine at Mount Sinai have received a grant from the National Institutes of Health to study Insulin-Like Growth Factor-1, a promising treatment for a subtype of autism called Phelan McDermid Syndrome.

27 Aug 2013

Sangamo BioSciences signs definitive agreement to buy Ceregene

Sangamo BioSciences, Inc. announced that it signed a definitive agreement to acquire Ceregene, Inc., a privately held biotechnology company focused on developing adeno-associated virus gene therapies.

26 Aug 2013

TRS receives FDA approval for Cranial Bone Void Filler product

Tissue Regeneration Systems, Inc. today announced that it has received 510K approval from the U.S. Food and Drug Administration for its Cranial Bone Void Filler product, indicated for use in the repair of neurosurgical burr holes.

26 Aug 2013

Scientists receive NIH grant to study commercially-available drug for treatment of PMS

Scientists at the Seaver Autism Center at the Icahn School of Medicine at Mount Sinai have received a grant from the National Institutes of Health (NIH) to study Insulin-Like Growth Factor-1 (IGF-1), a promising treatment for a subtype of autism called Phelan McDermid Syndrome (PMS).

26 Aug 2013

Athera Transfers Annexin A5 Project To Medirista

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23 Aug 2013

Shire extends existing partnership with Santaris Pharma in rare genetic disease space

Santaris Pharma A/S, a clinical-stage biopharmaceutical company focused on the discovery and development of RNA-targeted therapies, today announced that its long term partner, Shire has extended the existing partnership in the rare genetic disease space.

23 Aug 2013

Novel Approach Developed On Antitumor Immunotherapy

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22 Aug 2013

DFID awards 5-year grant to DNDi to advance research and development for neglected diseases

The UK Department for International Development (DFID) has announced its renewed support to the Drugs for Neglected Diseases initiative (DNDi), allocating a total of - 30 million (- 35 million) over the coming five years (2013-2018) to DNDi's Research & Development (R&D) portfolio to fight neglected diseases.

22 Aug 2013

Radiation Oncologist receives Young Investigator Award from PCF

Jefferson Radiation Oncologist, Nicole Simone, M.D., was recently awarded one of 21 Young Investigator Awards from the Prostate Cancer Foundation (PCF).

21 Aug 2013

Montana researcher receives $1M army grant to develop drug that limits damage caused by TBI

The U.S. Army has awarded University of Montana researcher Dave Poulsen a $1 million grant to further develop a drug that limits damage caused by traumatic brain injuries.

21 Aug 2013

Research suggests gene therapy approach may be feasible option to treat Rett Syndrome

The concept behind gene therapy is simple: deliver a healthy gene to compensate for one that is mutated. New research published today in the Journal of Neuroscience suggests this approach may eventually be a feasible option to treat Rett Syndrome, the most disabling of the autism spectrum disorders.

21 Aug 2013

Combination of anti-nausea drug and turmeric spice target cancer cells

In a laboratory, preclinical study recently published by the journal Organic & Biomolecular Chemistry, Virginia Commonwealth University Massey Cancer Center researchers combined structural features from anti-nausea drug thalidomide with common kitchen spice turmeric to create hybrid molecules that effectively kill multiple myeloma cells.

20 Aug 2013

Even in advanced stages total tumor size can have major impact on survival in lung cancer patients

For the two-thirds of lung cancer patients with locally advanced or metastatic disease, tumor size is not used currently to predict overall survival times. A new study, however, led by UT Southwestern Medical Center researchers has shown that even in advanced stages total tumor size can have a major impact on survival.

20 Aug 2013

Preclinical News and Research

Potential drug target to treat depression and other mood disorders may lie in GABA neurons

Albumin-bound paclitaxel has favorable risk–benefit profile in NSCLC

Future of biomedical innovation depends on new trend for all players to work together for common goal

Alzheimer’s drug trial: an interview with Geoffrey Kempler, Chairman & CEO Prana Biotechnology

Institut Curie's Emmanuel Barillot receives Agilent Thought Leader Award

CST introduces HER3 antibody for studying HER2-mediated breast, lung and ovarian tumors

BiondVax: Priming with universal flu vaccine makes conventional bird flu vaccine effective against pandemic strains

Mount Sinai scientists receive NIH grant to study clinical benefit of IGF-1 in children with PMS

Sangamo BioSciences signs definitive agreement to buy Ceregene

TRS receives FDA approval for Cranial Bone Void Filler product

Scientists receive NIH grant to study commercially-available drug for treatment of PMS

Athera Transfers Annexin A5 Project To Medirista

Shire extends existing partnership with Santaris Pharma in rare genetic disease space

Novel Approach Developed On Antitumor Immunotherapy

DFID awards 5-year grant to DNDi to advance research and development for neglected diseases

Radiation Oncologist receives Young Investigator Award from PCF

Montana researcher receives $1M army grant to develop drug that limits damage caused by TBI

Research suggests gene therapy approach may be feasible option to treat Rett Syndrome

Combination of anti-nausea drug and turmeric spice target cancer cells

Even in advanced stages total tumor size can have major impact on survival in lung cancer patients

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