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Scientists identify set of genes that could predict clinical outcomes in patients with FLT3-ITD AML

Researchers from the Cancer Science Institute of Singapore (CSI Singapore) at the National University of Singapore have identified a set of genes, including DNMT3A, that could potentially be used to predict clinical outcomes of patients who suffer from a type of Acute Myeloid Leukemia (AML) associated with an FLT3 internal tandem duplication (FLT3-ITD) mutation.

8 Jul 2016

Germline genetic testing necessary for men with metastatic prostate cancer

Men with metastatic prostate cancer should be considered for germline genetic testing of DNA repair genes, regardless of age or family history, according to a team of researchers from Memorial Sloan Kettering Cancer Center, Fred Hutchinson Cancer Research Center, Dana-Farber Cancer Institute, University of Washington School of Medicine, University of Michigan, and the Institute of Cancer Research Royal Marsden Hospital.

8 Jul 2016

Researchers discover mechanism of gene silencing in hormone-dependent breast cancer cells

Sometimes, the silencing of a gene is as important as its activation. Nonetheless, up to now, most studies on hormone-mediated gene regulation have focused on researching the factors that influence the activation of certain genes. Little attention has been paid to gene silencing.

8 Jul 2016

TSRI awarded $20 million for first year of precision medicine initiative cohort program

As part of the most ambitious medical research program in the history of American medicine, The Scripps Research Institute (TSRI) has received an initial award of $20 million for its role in a national precision medicine initiative, the National Institutes of Health (NIH) announced today.

8 Jul 2016

New study to investigate how genetic factors contribute to breast cancer disparities

The largest study ever to investigate how genetic and biological factors contribute to breast cancer risk among black women launched today.

7 Jul 2016

Whole-genome omics data can improve accuracy of breast cancer survival predictions

Precise predictions of whether a tumor is likely to spread would help clinicians and patients choose the best course of treatment. But current methods fall short of the precision needed.

6 Jul 2016

LouLou Foundation, ODC announce 11 new grants for research on CDKL5 deficiency

LouLou Foundation and the Orphan Disease Center (ODC) in the Perelman School of Medicine at the University of Pennsylvania are pleased to announce the award of 11 new research grants into CDKL5 deficiency - a rare X-chromosome-linked genetic disorder that causes severe neuro-developmental impairment and early-onset, difficult-to-control seizures.

5 Jul 2016

Novel technique could help discover genes linked to complex traits in any animal model

Mice are one of the most commonly used laboratory organisms, widely used to study everything from autism to infectious diseases. Yet genomic studies in mice have lagged behind those in humans.

4 Jul 2016

Study shows how genetic variants control immune cell response to pathogens

A study that is first in its kind and published in Nature Medicine today has looked at how far genetic factors control the immune cell response to pathogens in healthy individuals.

4 Jul 2016

Recommendations for integrating genomic results into clinical practice

A quiet transformation has been brewing in medicine, as large-scale DNA results become increasingly available to patients and healthcare providers.

1 Jul 2016

Kataegis linked to better prognosis for breast cancer patients

Kataegis is a recently discovered phenomenon in which multiple mutations cluster in a few hotspots in a genome. The anomaly was previously found in some cancers, but it has been unclear what role kataegis plays in tumor development and patient outcomes.

1 Jul 2016

Study focuses on critical proteins involved in ovarian cancer biology

In what is believed to be the largest study of its kind, scientists at the Pacific Northwest National Laboratory, Johns Hopkins University and their collaborators from institutions across the nation have examined the collections of proteins in the tumors of 169 ovarian cancer patients to identify critical proteins present in their tumors.

30 Jun 2016

Scientists develop new nonradioactive method to determine telomere length

UT Southwestern Medical Center cell biologists have identified a new method for determining the length of telomeres, the endcaps of chromosomes, which can influence cancer progression and aging.

30 Jun 2016

Scientists develop computational method to map cancer progression

A team of scientists has developed a computational method to map cancer progression, an advance that offers new insights into the factors that spur this affliction as well as new ways of selecting effective therapies.

28 Jun 2016

Virus-like elements within human genome linked to development of lupus and Sjogren's syndrome

Researchers at Hospital for Special Surgery have uncovered a potential genetic trigger of systemic autoimmune disease.

28 Jun 2016

Study offers array of new insights into nature of Plasmodium vivax

A team of scientists has uncovered the global, evolving, and historic make-up of Plasmodium vivax, one of the five species of malaria that infect humans.

28 Jun 2016

Genomic techniques help scientists understand diversity of P.vivax parasites

While most malaria research has focused on the parasite Plasmodium falciparum, which is common in Africa, another parasite, Plasmodium vivax (P.vivax) is responsible for the majority of malaria infections outside this region, causing an estimated 15.8 million clinical malaria cases each year.

28 Jun 2016

Blood levels of omega-3s fatty acids linked to lower risk of deadly heart attacks

Blood levels of seafood and plant-based omega-3 fatty acids are moderately associated with a lower risk of dying from heart attacks, according to a new epidemiological study, published today in JAMA Internal Medicine, led by Liana C. Del Gobbo, Ph.D., a postdoctoral research fellow in the division of cardiovascular medicine at Stanford University School of Medicine and senior author Dariush Mozaffarian, M.D., Dr.P.H., dean of the Friedman School of Nutrition Science and Policy at Tufts University in Boston.

28 Jun 2016

Vice President Biden to host Cancer Moonshot Summit in Washington, D.C.

Vice President Biden and Dr. Jill Biden will host a Cancer Moonshot Summit in Washington, D.C. at the White House. Cheryl Willman, MD, Director and CEO of The University of New Mexico Comprehensive Cancer Center, will attend.

25 Jun 2016

Oncogene signatures could help design new drug treatments for breast cancer

Drug treatments for breast cancer patients might soon be designed based on the unique genetic autograph of their tumor.

25 Jun 2016

Genomic News and Research

Scientists identify set of genes that could predict clinical outcomes in patients with FLT3-ITD AML

Germline genetic testing necessary for men with metastatic prostate cancer

Researchers discover mechanism of gene silencing in hormone-dependent breast cancer cells

TSRI awarded $20 million for first year of precision medicine initiative cohort program

New study to investigate how genetic factors contribute to breast cancer disparities

Whole-genome omics data can improve accuracy of breast cancer survival predictions

LouLou Foundation, ODC announce 11 new grants for research on CDKL5 deficiency

Novel technique could help discover genes linked to complex traits in any animal model

Study shows how genetic variants control immune cell response to pathogens

Recommendations for integrating genomic results into clinical practice

Kataegis linked to better prognosis for breast cancer patients

Study focuses on critical proteins involved in ovarian cancer biology

Scientists develop new nonradioactive method to determine telomere length

Scientists develop computational method to map cancer progression

Virus-like elements within human genome linked to development of lupus and Sjogren's syndrome

Study offers array of new insights into nature of Plasmodium vivax

Genomic techniques help scientists understand diversity of P.vivax parasites

Blood levels of omega-3s fatty acids linked to lower risk of deadly heart attacks

Vice President Biden to host Cancer Moonshot Summit in Washington, D.C.

Oncogene signatures could help design new drug treatments for breast cancer

The art of CRISPR: The power and promise of gene editing eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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