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New insights on replication-stress sensitivity in breast cancer cells

Oncotarget published "Frame-shift mediated reduction of gain-of-function p53 R273H and deletion of the R273H C-terminus in breast cancer cells result in replication-stress sensitivity" which reported that these authors recently documented that gain-of-function mutant p53 R273H in triple negative breast cancer cells interacts with replicating DNA and PARP1.

28 Jul 2021

Immunity to SARS-CoV-2 in renal transplant and dialysis patients using Pfizer/BioNTech and Moderna vaccines

A study analyzes the immune responses of medical personnel, as well as immunocompromised DP and immunosuppressed KTR patients.

27 Jul 2021

Gateway for Cancer Research funds EORTC 1634-BTG trial in post-pubertal brain tumor patients

Gateway for Cancer Research℠ awards grant to the EORTC 1634- Brain Tumour Group (BTG) academic trial in Post-Pubertal Patients with Newly-Diagnosed Medulloblastoma (PersoMed-I).

27 Jul 2021

Analysis of DNA tags could advance the understanding and treatment of many cancers

Cell-free DNA (cfDNA) shed into the blood was discovered in the late 1940s but with rapid advances in genomics and computational analytics in just the past few years, researchers at Georgetown Lombardi Comprehensive Cancer Center now believe that studying tags, or modifications to this type of DNA, may lead to a better understanding of how to assess, and possibly modulate, treatment approaches for cancer and other diseases.

27 Jul 2021

Biomarker shows potential to predict immunotherapy benefit for breast cancer patients

A biomarker that has proven to be a predictor for response to immunotherapies in melanoma patients also has clinical relevance for breast cancer patients, according to a new study published in Clinical Cancer Research, a journal of the American Association for Cancer Research.

27 Jul 2021

Breakthrough treatment could improve the immune system's ability to destroy cancer cells

New research has identified potential treatment that could improve the human immune system's ability to search out and destroy cancer cells within the body.

26 Jul 2021

Experts present new research to improve care for head and neck cancers at AHNS 2021

As the international community of experts in head-and-neck cancers gathered virtually last week to share new ideas and treatment strategies at the just-ended American Head & Neck Society (AHNS) 10th International Conference on Head and Neck Cancer, Roswell Park Comprehensive Cancer Center teams are presented new research on both the basic science supporting new treatments as well as opportunities to improve the early and accurate diagnosis of thyroid cancer and other head/neck malignancies.

26 Jul 2021

Comprehensive genomic sequencing essential to capitalize precision medicine for pediatric cancer care

St. Jude Children's Research Hospital investigators have demonstrated that comprehensive genomic sequencing of all pediatric cancer patients is feasible and essential to capitalize on the lifesaving potential of precision medicine.

26 Jul 2021

Researchers develop ovarian tumor microenvironment-chip to test novel ways to treat the disease

In the evolving field of cancer biology and treatment, innovations in organ-on-a-chip microdevices allow researchers to discover more about the disease outside the human body.

23 Jul 2021

Novel therapeutic agent could be effective for treating cancers with certain gene mutations

Mount Sinai researchers have developed a therapeutic agent that shows high effectiveness in vitro at disrupting a biological pathway that helps cancer survive, according to a paper published in Cancer Discovery, a journal of the American Association for Cancer Research, in July.

23 Jul 2021

Study brings scientists one step closer to solving the mystery of aging

The human body is essentially made up of trillions of living cells. It ages as its cells age, which happens when those cells eventually stop replicating and dividing.

23 Jul 2021

New radiotracer opens the door for advancement of iron-targeted cancer therapies

A new radiotracer that detects iron in cancer cells has proven effective, opening the door for the advancement of iron-targeted therapies for cancer patients.

23 Jul 2021

Researchers use mass spectrometry to study immunogenic SARS-CoV-2 epitopes

A new study has been published on the bioRxiv* preprint server, which has used MS to identify T cell epitopes of SARS-CoV-2 conserved protein, i.e., the membrane glycol protein (MGP) and the non-structure protein-13 (NSP13).

23 Jul 2021

Chemotherapy drugs can induce mutations that lead to relapse in pediatric ALL patients

Chemotherapy has helped make acute lymphoblastic leukemia (ALL) one of the most survivable childhood cancers.

22 Jul 2021

Investigational Oncomagnetic Device shrinks end-stage recurrent glioblastoma

Houston Methodist Neurological Institute researchers from the department of neurosurgery shrunk a deadly glioblastoma tumor by more than a third using a helmet generating a noninvasive oscillating magnetic field that the patient wore on his head while administering the therapy in his own home.

22 Jul 2021

Innovative testing platform could enable more precise, personalized immunotherapy

An innovative testing platform that more closely mimics what cancer encounters in the body may allow for more precise, personalized therapies by enabling the rapid study of multiple therapeutic combinations against tumor cells.

22 Jul 2021

Antibiotics may be the new weapon to fight against melanoma

Some antibiotics appear to be effective against a form of skin cancer known as melanoma. Researchers at KU Leuven, Belgium, examined the effect of these antibiotics on patient-derived tumours in mice. Their findings were published in the Journal of Experimental Medicine.

22 Jul 2021

Researchers use information theory to monitor resistance mechanisms to targeted cancer therapy

One of the major challenges in modern cancer therapy is the adaptive response of cancer cells to targeted therapies: initially, these therapies are very often effective, then adaptive resistance occurs, allowing the tumor cells to proliferate again.

21 Jul 2021

Protein involved in cell migration offers clues to cancer metastases

A protein involved in making cells move offers a clue to how certain types of cancer metastasize and develop into secondary tumors, according to new research from the University of Warwick.

21 Jul 2021

Study shows promise of combining radiation therapy with dendritic-cell vaccines for breast cancer

A research team led by Fumito Ito, MD, PhD, FACS, of Roswell Park Comprehensive Cancer Center reports new data on the promise of combining standard treatment for breast cancer with a particular form of cancer immmunotherapy - dendritic-cell (DC) treatment vaccines.

20 Jul 2021

Tumor News and Research

New insights on replication-stress sensitivity in breast cancer cells

Immunity to SARS-CoV-2 in renal transplant and dialysis patients using Pfizer/BioNTech and Moderna vaccines

Gateway for Cancer Research funds EORTC 1634-BTG trial in post-pubertal brain tumor patients

Analysis of DNA tags could advance the understanding and treatment of many cancers

Biomarker shows potential to predict immunotherapy benefit for breast cancer patients

Breakthrough treatment could improve the immune system's ability to destroy cancer cells

Experts present new research to improve care for head and neck cancers at AHNS 2021

Comprehensive genomic sequencing essential to capitalize precision medicine for pediatric cancer care

Researchers develop ovarian tumor microenvironment-chip to test novel ways to treat the disease

Novel therapeutic agent could be effective for treating cancers with certain gene mutations

Study brings scientists one step closer to solving the mystery of aging

New radiotracer opens the door for advancement of iron-targeted cancer therapies

Researchers use mass spectrometry to study immunogenic SARS-CoV-2 epitopes

Chemotherapy drugs can induce mutations that lead to relapse in pediatric ALL patients

Investigational Oncomagnetic Device shrinks end-stage recurrent glioblastoma

Innovative testing platform could enable more precise, personalized immunotherapy

Antibiotics may be the new weapon to fight against melanoma

Researchers use information theory to monitor resistance mechanisms to targeted cancer therapy

Protein involved in cell migration offers clues to cancer metastases

Study shows promise of combining radiation therapy with dendritic-cell vaccines for breast cancer

Industry Focus eBook - Cell & Gene Therapy (1st Edition) eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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